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Malaria
Category: Illness or disabilities
Type
Involuntary
Introduction and description
Malaria is a mosquito-borne disease of both humans and other animals. It is caused by eukaryotic protists of the genus Plasmodium.
There were an estimated 225 million cases of malaria worldwide in 2009 and an estimated 655,000 deaths from malaria in 2010. According to the World Health Organization’s 2011 World Malaria Report, malaria accounts for 2.23% of all deaths worldwide. However, a 2012 meta-study from the University of Washington and University of Queensland, published in the Lancet, estimated that 1,238,000 people died from malaria in 2010.
Ninety percent of malaria-related deaths occur in sub-Saharan Africa, around 60% of those deaths are of children under the age of five.
Symptoms
Symptoms include fever, headache, shivering, joint pain, vomiting, anaemia, jaundice, hemoglobinuria, retinal damage and convulsions.
The classic symptom of malaria is cyclical - sudden coldness and chills followed by shaking, and then fever and sweating lasting four to six hours, occurring every 2 to 3 days.
Children with malaria frequently exhibit abnormal posturing, a sign indicating severe brain damage. Malaria has been found to cause cognitive impairments, especially in children.
In severe cases malaria can progress to coma or death.
Causes
The disease is caused by the multiplication of Plasmodium parasites within red blood cells. This parasite is widespread in tropical and subtropical regions, including much of Sub-Saharan Africa, Asia, and the Americas.
Severe disease is largely caused by Plasmodium falciparum while the disease caused by Plasmodium vivax, Plasmodium ovale and Plasmodium malariae is less severe and is rarely fatal. Plasmodium knowlesi is a zoonosis that causes malaria in macaques but can also infect humans. While P. vivax is responsible for the largest number of malaria infections worldwide, infections by P. falciparum account for about 90% of deaths.
When an infected mosquito pierces a person's skin to take a blood meal, sporozoites in the mosquito's saliva enter the bloodstream and migrate to the liver. Within minutes of being introduced into the human host, the sporozoites move to the liver and infect hepatocytes, multiplying asexually and asymptomatically for a period of 8–30 days.
After a potential dormant period in the liver, these organisms differentiate to yield thousands of merozoites, which, following rupture of their host cells, escape into the blood and infect red blood cells, thus beginning the erythrocytic stage of the life cycle. The parasite escapes from the liver undetected by wrapping itself in the cell membrane of the infected host liver cell.
Within the red blood cells, the parasites multiply further, again asexually, periodically breaking out of their hosts to invade fresh red blood cells. Several such amplification cycles occur. Some P. vivax and P. ovale sporozoites do not immediately develop into exoerythrocytic-phase merozoites, but instead produce hypnozoites that remain dormant. After a period of dormancy, they reactivate and produce merozoites.
The parasite is relatively protected from attack by the body's immune system because for most of its human life cycle it resides within the liver and blood cells and is relatively invisible to immune surveillance. However, circulating infected blood cells are destroyed in the spleen.
Malaria can recur after treatment and can start some time after the mosquito bite that caused it. Approximately one in five of P. vivax malaria cases in temperate areas involve overwintering within the body by the hypnozoites; in other words, the illness begins the year after the mosquito bite. Because the parasite or its progeny can lay ‘dormant’ in the liver , even when the parasite has disappeared from the bloodstream, malaria can suddenly appear for no immediately apparent reason. The longest incubation period reported for a P. vivax infection was 30 years.
Treatment
Diagnosis
One of the first problems appears to be in diagnosis, as such treatment would be much improved if better diagnostic methods were used. The following chart is from Kenya.
Prevention
By far the best method of handling malaria is prevention. The use of mosquito nets which are inexpensive and easy to use, the use of natural mosquito repellants based on plants all help. The observations show some of the options that have been devised or discovered. Look under healing.
Here is a link to an inexpensive and apparently effective mosquito trap.
Treatment
A variety of anti-malarial pharmaceuticals are available and these have their own entry on this website as a number cause hallucinations, amongst other side-effects - one of which is death. Resistance has developed to several anti-malarial drugs, most notably chloroquine.
Severe malaria used to be treated with intravenous or intramuscular quinine, however, from the mid-2000s, the artemisinin derivative artesunate tends to be used more.
On a purely historical note, there is a story that the drink gin and tonic was devised by colonial administrators as a means of taking quinine in a more palatable way. As Wikipedia says:
"Tonic water (or Indian tonic water) is a carbonated soft drink, in which quinine is dissolved. Originally used as a prophylactic against malaria, tonic water usually now has a significantly lower quinine content and is consumed for its distinctive bitter flavour. It is often used in mixed drinks, particularly in gin and tonic."
So there you go, not enough quinine in tonic water these days for it to work. But there was once ................
The Imperial Cocktail - How the gin and tonic became the British Empire’s secret weapon. By Kal Raustiala
...the gin and tonic has a storied history that places it at the heart of the largest empire the world has ever known. Indeed, it is not too much of a stretch to say that the gin and tonic was as essential a weapon for the British Empire as the Gatling gun. No less an authority on imperial power than Winston Churchill once declared, “The gin and tonic has saved more Englishmen’s lives, and minds, than all the doctors in the Empire.”
What was the source of the gin and tonic’s great power? As is sometimes said of tequila, the gin and tonic is not just a drink; it’s a drug.
The story begins with the jewel of the British Empire: India. British India comprised both more and less than modern-day India. More, in that it included large parts of what are today Pakistan and Bangladesh. Less, in that much of India under the British Raj was quasi-independent, in so-called princely states that were nominally sovereign but largely under England’s thumb. India was so important to the empire that in 1876 Queen Victoria added the moniker “Empress of India” to her title. Her successors continued that practice right up till 1948, under George VI (he of The King’s Speech fame).
Controlling India, in short, was central to the British Empire and to Britain’s sense of itself as the world’s leading power. What allowed Britain, a small island far off in the northern reaches of Europe, to rule over the vast semi-continent of India for so long is a subject of some debate. But in Jared Diamond’s famous words, Europe’s military superiority was built on a mix of “guns, germs, and steel.”
Guns and steel clearly favored powers like Britain. These innovations allowed Britain (and other European countries) to deploy weapons such as machine guns at a time when many societies around the world still used swords and spears. But germs were more equivocal. Malaria in particular was a virulent killer of colonized and colonizer alike. While malaria has a long history in Europe, it began to be eradicated in the 19th century, and even earlier it was never as deadly as it was in tropical locations. So as Europeans established colonies in the tropics, they faced a serious and often mortal threat from the mosquito-borne disease. Soldiers and civilian officials alike succumbed to it.
In the 17th century, the Spanish had discovered that indigenous peoples in what is now Peru used a kind of bark to address various “fevers.” Stripped from the cinchona tree, the bark seemed to work well for malaria. The “Jesuit’s bark,” as it was known, quickly became a favored treatment for malaria in Europe. (Before the discovery of the cinchona tree, European malaria remedies included throwing the patient head-first into a bush in the hope he would get out quickly enough to leave his fever behind.)
Eventually it became clear that cinchona bark could be used not only to treat malaria, but also to prevent it. The bark—and its active ingredient, quinine powder—was a powerful medicine. But it was also a powerful new weapon in the European quest to conquer and rule distant lands.
Probably still works if you can find the right tonic water.
How it works
The healing observations each describe how it is thought healing works. In terms of the hallucinations or other experiences [including near death and out of body] which malaria can produce, the primary cause appears to be the fever and hyperthermia that results. It produces delirium.
Related observations
Healing observations
- Activity of Herbal Medicines on Plasmodium falciparum Gametocytes: Implications for Malaria Transmission in Ghana 020983
- An account of the success of the Bark of the Willow in the Cure of Agues - Rev. Mr. Edmund Stone 1763 020518
- Anti-plasmodial activity of the extracts and two sesquiterpenes from Cyperus articulatus 020545
- Antimalarial activity of some Colombian medicinal plants 019355
- Antimalarial evaluation of the leaf latex of Aloe citrina and its major constituent 020985
- Antimalarial use of volatile oil from leaves of Virola surinamensis (Rol.) Warb. by Waiãpi Amazon Indians 018282
- Antiplasmodial activity of New Caledonia and Vanuatu traditional medicines 021403
- Antiplasmodial potential of traditional phytotherapy of some remedies used in treatment of malaria in Meru-Tharaka Nithi County of Kenya 019172
- Antiprotozoal activities of organic extracts from French marine seaweeds 016968
- Bingen, Hildegard of - Cinnamon 022699
- Carum copticum L.: A Herbal Medicine with Various Pharmacological Effects - Antiparasitic activities 027883
- Catmint and malaria 006772
- Centaury tea - The Healing power of Herbal teas – Ceres Esplan 019451
- Chicory and malaria 005291
- Colonial G&T 012742
- Croll, Oswald - Preface of Signatures – 10 016028
- Devil's Claw-a review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens 016804
- Dr Duke on Artemisia Annua 012751
- Dr Duke's Analysis of Tabernanthe iboga 017451
- Dr Duke's list of Anti-parasitic activity for the Dock 018085
- Dr Duke's list of chemicals and activity for the Shallot 017969
- Dr Duke's list of Chemicals and their Biological Activities in Pilocarpus microphyllus 018158
- Dr Duke's list of Chemicals and their Biological Activities in: Menyanthes trifoliata L. (Menyanthaceae) -- Bog Myrtle, Bogbean, Buckbean, Marsh Clover, Marsh Trefoil, Water Trefoil 018266
- Dr Duke's list of Chemicals and their Biological Activities in: Opopanax chironium (L.) KOCH (Apiaceae) -- Hercules All Heal, Opopanax 018264
- Dr Duke's list of Chemicals and their Biological Activities in: Prunella vulgaris L. (Lamiaceae) -- Heal-All, Self-Heal 018270
- Dr Duke's list of chemicals having anti-malarial activity 018059
- Dr Duke's list of Plants with Antimalarial activity 018057
- Dr Duke's list of Plants with Antimalarial activity of high chemical potency 018058
- Dr Duke's list of Plants with Plasmodicidal activity 018296
- Dr Duke's list of Plants with Plasmodicidal activity of high chemical potency 018297
- Dr Duke's list of the Biological Activities of RUTIN 018281
- Dr Duke’s list of Antiparasitic Activities in: Ailanthus altissima -- Stinktree, Tree Of Heaven 018308
- Dr Duke’s list of Ethnobotanical use for Leonotis nepetifolia (Lamiaceae) Gros Pompon; Pompon; Grasse Mulatre; Gros Tete; Salbadi; Rumbut tambak-tambak rimba; Molinillo; Cevadille 021425
- Effective malaria treatments in Brazil 012745
- Elderberries and malaria 006770
- Extent of Use of Aloe vera Locally Extracted Products for Management of Ailments in Communities of Kitagata Sub-county in Sheema District, Western Uganda 020986
- Farrelly, Frances - 'Kay' feels others illness 004159
- Farrelly, Frances - Diagnosing diabetes and blood clot 004212
- Farrelly, Frances - Diagnosing TB in the ear 004213
- Farrelly, Frances - Pain in the bum 004217
- Farrelly, Frances - Remote diagnosis using blood 004214
- Folk phytotherapeutical plants from Maratea area (Basilicata, Italy 019478
- Hack Tuke, Daniel – Healing - Ague cured by suggestion and charms, amulets, and spells 026194
- Homeopathic medicine and malaria 012148
- Homeopathy for Collective Diseases - AIDs, Malaria, Trauma, Vaccines and Toxins - The quest for a collective simillimum 012621
- In vitro activities of plant extracts from Saudi Arabia against malaria, leishmaniasis, sleeping sickness and Chagas disease. 022065
- Larvicidal effect of aqueous and ethanolic extracts of Senna alata on Anopheles gambiae, Culex quinquefasciatus and Aedes aegypti 021420
- Malaria in pregnant women, quinine and artemisia 012743
- Management of suspected cases of malaria before admission to a district hospital in Burkina Faso 012744
- Marigolds and malaria 010334
- Marigolds and tick control 010336
- Marigolds, malaria and Aedes aegypti 010335
- Metagenomic testing as a means of identifying the pathogens causing Blood circulatory system diseases 026769
- Mrs Grieve on Alder 020504
- Mrs Grieve on Avens 019740
- Mrs Grieve on Winterberry 020503
- New findings on Simalikalactone D, an antimalarial compound from Quassia amara L 019148
- Patent literature on mosquito repellent inventions which contain plant essential oils--a review 016774
- Picralima nitida - a review of uses 010380
- Picralima Nitida and Malaria 010382
- Short Communication: Studies of antimicrobial activity and chemical constituents of Ximenia americana 019175
- Simalikalactone D is responsible for the antimalarial properties of an amazonian traditional remedy made with Quassia amara 019146
- Summary of Antipathogenic Activities in: Phellodendron amurense -- Amur Cork Tree, Huang Bai, Huang Po, Po Mu 018332
- Summary of Dr Duke’s analysis showing the Antipathogenic Activities in: Azadirachta indica -- Neem 018320
- The Healing Power of Sleep 026790
- The serodiagnosis of parasitic infections 012737
- Zinc and childhood infectious diseases 006868
Hallucination
- Aralen 018006
- Fawcett, Lt Colonel Percival Harrison - And the scourge of malaria and yellow fever 022766
- Hallucinations from malaria 006104
- Heywood, Rosalind - The Infinite Hive - Ghastly gorilla-like devils that leered at me out of an immense gold embossed Victorian frame 023048
- Keightley, Thomas - The Elle woman 002576
- Malaria treatments, psychoses and anorexia 012798
- Malarone 019491
- Mepron 019512
- Metastatic malignant melanoma and Hallucination - from FDA reports 024203
- Parasitosis of the Central Nervous system 012791
- Pathology of CNS parasitic infections 012792
- Permethrin 021364
- Washington, George - A vision and a prophecy 004227
Wisdom, Inspiration, Divine love & Bliss
- Krishnamurti - The Song of Life - Life is as the waters 000136
- Lawrence, D H - from The Ship of Death 001099
- Lawrence, D H - Promises 1929 013234
- Lawrence, D H - The Bride 001100
- Masefield, John - A Creed 001623
- Masefield, John - A White Night 001886
- Masefield, John - I was folk's contrary son 001626
- Masefield, John - It’s a warm wind, the west wind, full of birds’ cries 001474
- Masefield, John - Shakespeare and spiritual life 003509
- Masefield, John - Shakespeare and spiritual life 003508
- Masefield, John - Shakespeare and spiritual life 003507
- Masefield, John - Shakespeare and spiritual life 003506
- Masefield, John - Shakespeare and spiritual life 003505
- Masefield, John - Shakespeare and spiritual life 003504
- Masefield, John - Shakespeare and spiritual life 003510
- Masefield, John - Sonnets and Poems XII 001472
- Masefield, John - Sonnets and Poems XXXII 001022
- Masefield, John - The Story of a Round-House - Sonnet 001624
- Masefield, John - The Widow in the Bye Street 004509
- Wallace, Alfred Russell - Conceives the idea of natural selection 001544
Out of time
Enlightenment
In time
- Farrelly, Frances - 'Kay' feels others illness 004159
- Farrelly, Frances - Diagnosing diabetes and blood clot 004212
- Farrelly, Frances - Diagnosing TB in the ear 004213
- Farrelly, Frances - Meteorites and missing people 004216
- Farrelly, Frances - Pain in the bum 004217
- Farrelly, Frances - Remote diagnosis using blood 004214
- Farrelly, Frances - Sensing the sadness in a ring 004238
- Farrelly, Frances - Super mice saved from poison 004210
- Farrelly, Frances - Warning of a blown tyre 004215
- Homeopathy for Collective Diseases - AIDs, Malaria, Trauma, Vaccines and Toxins - The quest for a collective simillimum 012621
- Osty, Dr Eugene - Supernormal faculties in Man – Mdlle de Berly a prognosis and a prophecy 025454
- Washington, George - A vision and a prophecy 004227
Prophecy
- Farrelly, Frances - Saved from train crashes 004208
- Osty, Dr Eugene - Supernormal faculties in Man – Mdlle de Berly a prognosis and a prophecy 025454
- Vereshchagin, Vasily - A premonition of his own death 025411
- Washington, George - A vision and a prophecy 004227
Environmental Influence
- Farrelly, Frances - Spinning coins to order heads or tails 004198
- Farrelly, Frances - Super mice saved from poison 004210