Anti-plasmodial activity of the extracts and two sesquiterpenes from Cyperus articulatus
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Plasmodium falciparum is a protozoan parasite, one of the species of Plasmodium that cause malaria in humans. It is transmitted by the female Anopheles mosquito. Malaria caused by this species (also called malignant or falciparum malaria) is the most dangerous form of malaria, with the highest rates of complications and mortality. As of the latest World Health Organization report in 2015, there were 214 million cases of malaria worldwide. This resulted in an estimated 438,000 deaths
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Fitoterapia. 2008 Apr;79(3):188-90. doi: 10.1016/j.fitote.2007.11.010. Epub 2007 Dec 3.
Anti-plasmodial activity of the extracts and two sesquiterpenes from Cyperus articulatus.
Rukunga GM1, Muregi FW, Omar SA, Gathirwa JW, Muthaura CN, Peter MG, Heydenreich M, Mungai GM.
- 1Kenya Medical Research Institute (KEMRI), PO BOX 54840, Nairobi, Kenya. email@example.com
Two sesquiterpenes, corymbolone and mustakone, isolated from the chloroform extract of the rhizomes of Cyperus articulatus, exhibited significant anti-plasmodial properties. Mustakone was approximately ten times more active than corymbolone against the sensitive strains of the Plasmodium falciparum.