J Ethnopharmacol. 2006 Oct 11;107(3):460-2. Epub 2006 Apr 15.

Antimalarial activity of some Colombian medicinal plants.

Garavito G1, Rincón J, Arteaga L, Hata Y, Bourdy G, Gimenez A, Pinzón R, Deharo E.

• 1Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Carrera 30 45-02, Bogotá D.C., Colombia. ggaravito@unal.edu.co

Abstract

Antimalarial activity of 10 vegetal extracts (9 ethanolic extracts and 1 crude alkaloid extract), obtained from eight species traditionally used in Colombia to treat malaria symptoms, was evaluated in culture using Plasmodium falciparum chloroquine resistant (FcB2) strain and in vivo on rodent malaria Plasmodium berghei. The activity on ferriprotoporphyrin biomineralization inhibition test (FBIT) was also assessed. Against Plasmodium falciparum, eight extracts displayed good activity

• Abuta grandifolia (Mart.) Sandwith (Menispermaceae) leaves,
• Acacia farnesiana (L.) Willd. (Mimosaceae) leaves,
• Acnistus arborescens (L.) Schltdl. (Solanaceae) aerial part,
• Croton leptostachyus Kunth (Euphorbiaceae) aerial part,
• Piper cumanense Kunth (Piperaceae) fruits and leaves,
• Piper holtonii C. DC. (Piperaceae) aerial part and
• Xylopia aromatica (Lam.) Mart. (Annonaceae) bark

with IC(50) values ranging from <1 to 2.1 microg/ml, while in the in vivo model only Abuta grandifolia alkaloid crude extract exhibits activity, inhibiting 66% of the parasite growth at 250 mg/kg/day. In the FBIT model, five extracts were active (Abuta grandifolia, Croton leptostachyus, Piper cumanense fruit and leaves and Xylopia aromatica).

PMID:

16713157