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Observations placeholder

Nicotine, coffee, cannabis and dopamine



Type of Spiritual Experience


You may have to read this a number of times and explore the links to understand the connections.

It isn't the tobacco per se it is the nicotine

Vitamin C is ascorbic acid.

The richest natural sources of Vitamin C are practically all fruits eg citrus fruits, kiwi fruit, lychees, elderberries, papayas, strawberrries, plums, gooseberries, rose hips, chilli peppers, red peppers, guava, blackcurrants, melon, raspberry, blackberries, mango, tomatoes, cranberry, blueberry, grapes, apricots, banana, avocado, cherry, peach, pear, apple);  herbs (especially parsley); onions and garlic;  and practically all vegetables eg brussel sprouts, broccoli, kale, spinach, cabbage, potatoes, carrots, lettuce, beetroot, aubergine etc.  Raisins and figs are also good sources.  It is also present in liver, oysters, cod roe, goat’s milk, camel’s milk, lamb’s heart, lamb’s tongue and human milk. 

A description of the experience

Pharmacol Biochem Behav. 2002 Jul;72(4):811-6. Cannabis, tobacco, and caffeine use modify the blood pressure reactivity protection of ascorbic acid. Brody S, Preut R. Center for Psychosomatic and Psychobiological Research, University of Trier, Trier, Germany. stuartbrody@hotmail.com

Cannabis, caffeine, and tobacco use are associated with increased mesolimbic dopamine activity.

Ascorbic acid (AA) modulates some dopaminergic agent effects, and was recently found to decrease systolic blood pressure (SBP) stress reactivity.

To examine how AA SBP stress reactivity protection varies by use of these substances, data from an AA trial (Cetebe, 3000 mg/day for 14 days; N=108) were compared by substance use level regarding SBP reactivity to the anticipation and actual experience phases of a standardized psychological stressor (10 min of public speaking and arithmetic).

Self-reported never users of cannabis, persons not currently smoking tobacco, and persons consuming three or more caffeine beverages daily all exhibited AA SBP stress reactivity protection to the actual stressor, but not during the anticipation phase.

Conversely, self-reported ever cannabis users, current tobacco smokers, and persons consuming less than three caffeine beverages daily exhibited the AA SBP protection during the anticipation phase, but only the lower caffeine consumption group exhibited AA protection during both phases.

Covariates (neuroticism, extraversion, and depression scores, age, sex, body mass index) were all nonsignificant.

Results are discussed in terms of dopaminergic effects of these substances, modulation of catecholaminergic and endothelial activity, and AA support of coping styles.

PMID: 12062570

The source of the experience


Concepts, symbols and science items



Science Items

Activities and commonsteps