Fungal infection treatments
Introduction and description
Antifungal drugs are pharmaceuticals used to treat mycoses – fungal infections. We urge you to read the sections on fungal infections and that on Candidiasis as they provide important information about the causes of these infections and how they can be prevented.
The healing observations provide details of treatments that actually cure fungal infections. The drugs in this category generally tend to deal with the symptoms and not the cause of the infection.
Types and examples
Depending on the nature of the infection, a topical or systemic agent may be used. In effect, the pharmaceutical may be applied to the skin, ingested or even injected into a vein. Other therapies exist for treating fungal infections, but are not classed within this class of drugs. The class covers a wide range of drugs with different mechanisms of action, as such it is easier to look at each drug to understand how it is theoretically supposed to work.
An example of an antifungal is fluconazole, or Diflucan, which is the basis of many over-the-counter antifungal treatments. Another example is amphotericin B (the A form being toxic) which is more potent. It is used in the treatment of the most severe fungal infections that show resistance to other forms of treatment and it is administered intravenously
Drugs to treat skin infections are Tolnaftate (Tinactin), an over the counter topical; Ketoconazole, especially used to treat tinea versicolor and other dermatophytes; Itraconazole; Terbinafine (Lamisil); Echinocandins (caspofungin); Griseofulvin, commonly used for infections involving the scalp and nails.
Yeast infections in the vagina, caused by candida albicans, are treated with medicated suppositories such as tioconazole and pessaries whereas skin yeast infections are treated with medicated ointments.
And they have caused spiritual experiences – principally hallucinations.
In June 2016, eHealthme ceased to provide the information on which all the data in this section is based. On querying my friends in the USA, it would seem that many of the sites that provided similar information, have done the same. The links we provided to eHealthme also no longer work as this data too has been removed.
As to why all these sites have removed exceptionally important information, my USA helpers said that more and more people are questioning what they are being given – and demanding to know WHY the CAUSE of their illness has not been investigated. It appears that there has been a very heartening increase in the numbers of people who want to be healed – have the cause tackled and not the symptoms. And this is ‘not popular’ with the conventional medical community, who cannot make money from well people.
The statistics collected from eHealthme remain valid for the date they were collected. As such we have left this section as it is – an historical record. Please read this section therefore only as an historical record of the figures that were applicable on the date specified.
Applied on the skin, the side effects of many anti-fungals are mild. But the spiritual experiences and the adverse reactions of this class of pharmaceuticals appear to be all caused by ingestion and injection. And the side effects are indeed severe. Many side effects and adverse drug reactions have been reported with all these drugs "possibly due to their extensive biodistribution and the often extended durations involved in anti-fungal treatment":
- Stomach disease and Intestine disease - Gastrointestinal Problems - Diarrhea, constipation, nausea, sickness, fullness, abdominal pain, indigestion, dyspepsia, gastritis, cholestasis, flatulence, altered stool colour, abdominal muscular pain.
- Central Nervous System / Neurological Problems Headaches, dizziness, vertigo, light-headedness, decreased concentration levels, paraesthesia (pins and needles)
- Liver problems - Hepatic Problems Raised liver enzymes, liver inflammation (hepatitis), liver damage, liver failure
- Immune System Problems - Decreased white blood cell counts including pancytopenia, leukopenia, lymphopenia, thrombocytopenia, agranulocytosis, and neutropenia. Auto-immune reactions such as lupus erythematosus
- Psychological Problems Depression, anxiety, insomnia, increased / unusual dream activity, malaise.
- Sensory Problems Complete loss of taste (ageusia), decreased taste (hypogeusia) and distorted taste (dysgeusia) often involving a metallic taste sensation and dry mouth.
- Visual disturbances including hallucinations, blurred vision, green vision and double vision.
- Skin Problems - Rash, hives. (urticaria), skin irritation, itching (pruritis), jaundice, Stevens-Johnson syndrome.
- Nephrotoxicity (kidney damage) is a frequently reported side effect, and can be severe and/or irreversible.
- Electrolyte imbalances (e.g. hypokalemia and hypomagnesemia) may also result.
- Blood system - In the circulatory system, several forms of anemia and other blood dyscrasias (leukopenia, thrombopenia)
- Heart failure - serious cardiac arrhythmias (including ventricular fibrillation), and even cardiac failure have been reported. Also hypotension and hypertension.
- Fever and hyperthemia - shaking, chills, high fever
- Cancer - some antifungals are phototoxic and have been associated with an increased risk of squamous-cell carcinoma of the skin.
Using the Adverse Drug Reports from eHealthme submitted by doctors to the FDA and SEDA in the USA only [thus excluding the rest of the world], the following figures for deaths from these drugs were correct as at March 2016:
Amphotericin b and its trade names
- On Mar, 11, 2016: 4,958 people reported to have side effects when taking Amphotericin b. Among them, 101 people (2.04%) have Death
- On Apr, 1, 2016: 2,318 people reported to have side effects when taking Fungizone. Among them, 22 people (0.95%) have Death
Diflucan and other trade names
- On Mar, 3, 2016: 17,157 people reported to have side effects when taking Diflucan. Among them, 293 people (1.71%) have Death
- On Mar, 31, 2016: 19,847 people reported to have side effects when taking Fluconazole. Among them, 467 people (2.35%) have Death
Lamisil and its trade names
- On Mar, 29, 2016: 6,902 people reported to have side effects when taking Lamisil. Among them, 39 people (0.57%) have Death
- On Mar, 21, 2016: 495 people reported to have side effects when taking Terbinafine hydrochloride. Among them, 1 people (0.20%) has Death
Mycelex and other trade names
- On Apr, 1, 2016: 1,492 people reported to have side effects when taking Mycelex. Among them, 55 people (3.69%) have Death
- On Mar, 3, 2016: 2,987 people reported to have side effects when taking Clotrimazole. Among them, 76 people (2.54%) have Death
- On Apr, 1, 2016: 585 people reported to have side effects when taking Lotrimin. Among them, 8 people (1.37%) have Death.
- On Apr, 1, 2016: 131 people reported to have side effects when taking Lotrimin af. Among them, 1 people (0.76%) has Death
Mycostatin and trade names
- On Mar, 26, 2016: 1,360 people reported to have side effects when taking Mycostatin. Among them, 39 people (2.87%) have Death
- On Mar, 26, 2016: 8,926 people reported to have side effects when taking Nystatin. Among them, 294 people (3.29%) have Death
- On Apr, 1, 2016: 84 people reported to have side effects when taking Nystop. Among them, 1 people (1.19%) has Death
Rapamune and brand names
- On Mar, 6, 2016: 7,410 people reported to have side effects when taking Rapamune. Among them, 186 people (2.51%) have Death
- On Apr, 1, 2016: 1,895 people reported to have side effects when taking Sirolimus. Among them, 53 people (2.80%) have Death
Itraconazole and brand names
- On Mar, 8, 2016: 5,485 people reported to have side effects when taking Itraconazole. Among them, 77 people (1.40%) have Death
- On Apr, 1, 2016: 4,267 people reported to have side effects when taking Sporanox. Among them, 161 people (3.77%) have Death
Voriconazole and brand names
- On Apr, 1, 2016: 5,500 people reported to have side effects when taking Vfend. Among them, 469 people (8.53%) have Death
- On Mar, 11, 2016: 2,850 people reported to have side effects when taking Voriconazole. Among them, 126 people (4.42%) have Death
Using the Adverse Drug Reports from eHealthme submitted by doctors to the FDA and SEDA in the USA only [thus excluding the rest of the world], the following figures were correct as at March 2016:
No of people with Side effects: 144,649
No of deaths 2,448
How it works
Given the number of side effects, the most obvious thing to say would be that they work to give you a spiritual experience via one of these illnesses, but ultimately it might be better to say antifungals give you a spiritual experience because they are toxins, or if you prefer poisons.
The total of all the hallucinations caused by these drugs as derived from the eHealthme web site is shown in the table below. It was correct as of 2016. The link takes you to the entry for the drug on ehealthme and an up-to-date list of side effects.
No of hallucinations
- A protein with antiproliferative, antifungal and HIV-1 reverse transcriptase inhibitory activities from caper (Capparis spinosa) seeds 022061
- Analysis and in vitro anti-Candida antifungal activity of Cuminum cyminum and Salvadora persica herbs extracts against pathogenic Candida strains 019915
- Anti-Candida activity of Brazilian medicinal plants 020544
- Anti-HBV effect of individual traditional Chinese herbal medicine in vitro and in vivo: an analytic review 017490
- Antifungal activities and chemical composition of some medicinal plants 023032
- Antifungal activity of plant extracts against dermatophytes 022062
- Antifungal activity of salicylic acid against Penicillium expansum and its possible mechanisms of action 020512
- Antifungal and antioxidant activities of the phytomedicine pipsissewa, Chimaphila umbellata 019571
- Antimicrobial activities of Aerva javanica and Paeonia emodi plants 019429
- Antimicrobial activity of natural products from the flora of Northern Ontario, Canada 019569
- Antimicrobial activity of some Alnus species 021023
- Antiradical activity of natural honeys and antifungal effect against Penicillium genera 020541
- Aspergillosis and Hallucination, auditory - from FDA reports 024505
- Berberine 019950
- Chicory and antibiotics 005293
- Crown Court Case worker - and the agony of amalgam fillings 012316
- Dr Duke's activity for Carnosol 017757
- Dr Duke's activity in Caffeic acid 017760
- Dr Duke's list of activities for Chlorogenic acid 017767
- Dr Duke's list of activity for Ferulic acid 017775
- Dr Duke's list of activity for the chemical Daidzein 017895
- Dr Duke's list of chemicals and activity for the Shallot 017969
- Dr Duke's list of Chemicals and their Biological Activities in Pilocarpus microphyllus 018158
- Dr Duke's list of Plants with Candidicide activity 018389
- Evaluation of antioxidant and antifungal properties of the traditional plants against foodborne fungal pathogens 019912
- Fabin, a novel calcyon-like and glucanase-like protein with mitogenic, antifungal and translation-inhibitory activities from broad beans 022044
- Garlic and health 005408
- Gentian Violet: A 19th Century Drug Re-Emerges in the 21st Century 026150
- In Vitro Effects of Plantago Major Extract, Aucubin, and Baicalein on Candida Albicans Biofilm Formation, Metabolic Activity, and Cell Surface Hydrophobicity 021160
- Incidence of Candida in psoriasis--a study on the fungal flora of psoriatic patients 021024
- Isolation, purification, and characterization of a stable defensin-like antifungal peptide from Trigonella foenum-graecum (fenugreek) seeds 019974
- Mechanisms involved in the chemoprotective effects of rosemary extract studied in human liver and bronchial cells 017758
- Propolis C Albicans, MRSA and E Coli 005340
- Screening of some indigenous Qatari medicinal plants for antimicrobial activity 022064
- Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases 019953
- Single-blind study of manuka honey in allergic fungal rhinosinusitis 019899
- Stephen Harrod Buhner - Herbal Antivirals - Ginger 017501
- Stephen Harrod Buhner - Herbal Antivirals - Skullcap 017499
- Thrush and anise 006259
- Adverse drug events complicate antifungal therapy for pulmonary aspergilloma 023027
- Amphotericin 006894
- Aspergillosis and Hallucination, auditory - from FDA reports 024505
- Auditory hallucinations due to voriconazole: Illustration by plasma monitoring 023025
- Butoconazole 018132
- Cancidas 018164
- Ciclopirox 018205
- Clozapine toxicity due to a multiple drug interaction: a case report 017915
- Diflucan and Fluconazole 006895
- Hallucinations and hypoglycaemia from anti-fungal 013001
- Itraconazole 024060
- Ketoconazole 024063
- Lamisil 006893
- Lotrimin 019279
- Mepron 019512
- Monistat 019544
- Musical hallucinations from antifungal 006896
- Mycelex and Clotrimazole 019558
- Mycostatin 019562
- Neurologic Adverse Events Associated with Voriconazole Therapy: Report of Two Pediatric Cases 023028
- Nizoral 019699
- Noxafil 019719
- Nystop [Nystatin] 019728
- Penlac 019835
- Prostatic and Central Nervous System Histoplasmosis in an Immunocompetent Host: Case Report and Review of the Prostatic Histoplasmosis 027569
- Rapamune, Rapamycin and Sirolimus 015689
- Sporanox 020045
- The Netherlands Centre for Monitoring of Adverse Reactions to Drugs 1992 016811
- Triamcinolone 015759
- Vfend 020364
- VFEND 006897
- Voriconazole 020376
- Voriconazole-associated visual disturbances and hallucinations 023024
- Voriconazole-induced musical hallucinations 023026