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Observations placeholder

The Netherlands Centre for Monitoring of Adverse Reactions to Drugs 1992



Type of Spiritual Experience


Number of hallucinations: 1


Sumatriptan is a medication used for the treatment of migraine headaches

Itraconazole (R51211), invented in 1984, is a triazole antifungal agent prescribed to patients with fungal infections.

Terbinafine hydrochloride, also known under the trade name Lamisil is a synthetic allylamine antifungal. It is highly hydrophobic in nature and tends to accumulate in skin, nails, and fatty tissues.

Deptropine (Brontina) also known as dibenzheptropine, is an antihistamine with anticholinergic properties. It is usually marketed as the citrate salt

Nalbuphine is a semi-synthetic opioid used commercially as an analgesic under a variety of trade names, including Nubain.

Terodiline is a drug used in urology as an antispasmodic.  It relaxes the smooth muscle and used to reduce bladder tone in treatment of urinary frequency and incontinence. Muscle relaxation caused by terodiline, is "probably due to its anticholinergic and calcium antagonist activity".  However, it also blocks IKr (Kv11.1) channels so can pose a risk for torsades de pointes. This cardiotoxicity is concentration dependent

Neuroleptics are antipsychotics

Diclofenac  is a nonsteroidal anti-inflammatory drug (NSAID)

Vigabatrin, also known as gamma-vinyl-GABA, is an antiepileptic drug

A description of the experience

Ned Tijdschr Geneeskd. 1993 Aug 28;137(35):1784-7.  [Recording of possible side effects in the Bureau for Side Effects of Drugs and research activities in 1992].  [Article in Dutch]  Stricker BH1, Ottervanger JP.

In 1992, the Netherlands Centre for Monitoring of Adverse Reactions to Drugs received 1248 reports of suspected adverse reactions. The most important reports concerned

  • chest pain to sumatriptan,
  • cholestatic hepatitis to itraconazole
  • and taste loss to terbinafine.

Other important reports pertained to

  • confusion and hallucinations in children on deptropine,
  • postasphyctic encephalopathy of a newborn after intrapartum administration of nalbuphine,
  • torsades de pointes to terodiline,
  • fever to neuroleptics,
  • muscle necrosis to intramuscular administration of diclofenac,
  • gout during use of acetylsalicylic acid,
  • psychic effects of vigabatrine and
  • sudden death during fluorescence angiography.

It is the policy of the Netherlands centre to publish as many relevant reports as possible in order to facilitate medical practitioners to adapt their pharmacotherapeutic choice. In close collaboration with several universities, the Netherlands centre currently develops systems and methods for postmarketing surveillance.

PMID:  8371825

The source of the experience


Concepts, symbols and science items




Science Items

Activities and commonsteps