Thrush and anise
Type of Spiritual Experience
This is Gerard's 'white flux'
A description of the experience
J Gen Appl Microbiol. 2011;57(3):129-36. Exposure of Candida to p-anisaldehyde inhibits its growth and ergosterol biosynthesis. Shreaz S, Bhatia R, Khan N, Muralidhar S, Basir SF, Manzoor N, Khan LA. Department of Biosciences, Jamia Millia Islamia, New Delhi-110025, India.
p-Anisaldehyde (4-methoxybenzaldehyde), an extract from Pimpinella anisum seeds, is a very common digestive herb of north India.
Antifungal activity of p-anisaldehyde was investigated on 10 fluconazole-resistant and 5 fluconazole-sensitive Candida strains.
Minimum inhibitory concentrations (MIC(90)) ranged from 250 µg/ml to 600 µg/ml for both sensitive and resistant strains. Ergosterol content was drastically reduced by p-anisaldehyde-62% in sensitive and 66% in resistant strains-but did not correlate well with MIC(90) values.
It appears that p-anisaldehyde exerts its antifungal effect by decreasing NADPH routed through up-regulation of putative aryl-alcohol dehydrogenases. Cellular toxicity of p-anisaldehyde against H9c2 rat cardiac myoblasts was less than 20% at the highest MIC value. These findings encourage further development of p-anisaldehyde.