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Observations placeholder

Voriconazole-induced musical hallucinations

Identifier

023026

Type of Spiritual Experience

Hallucination

Number of hallucinations: 1

Background

A description of the experience

Infection. 2004 Oct;32(5):293-5.  Voriconazole-induced musical hallucinations.  Agrawal AK1, Sherman LK. 1Baylor College of Medicine, Houston, Texas, USA.

1 Voriconazole (Vfend) is a second-generation azole antifungal that is increasing in popularity especially for the treatment of invasive aspergillosis as well as empirically for the febrile neutropenic patient.

In addition, voriconazole tends to have a mild side effect profile with reversible visual disturbances being the most widely described effect.

We describe a patient who had musical hallucinations secondary to voriconazole.

The patient was a 78-year-old man admitted for induction of chemotherapy for acute myelogenous leukemia (AML) who began to have auditory hallucinations, specifically of Christmas music, the 2nd day of voriconazole therapy. His psychiatric evaluation was otherwise unremarkable. After discontinuing voriconazole the hallucinations decreased in intensity by the 2nd day and ceased altogether by the 3rd day.

An extensive literature search, including Pfizer drug trial safety data, yielded no other reports of auditory hallucinations with voriconazole. Several other interesting cases of musical hallucinations secondary to a variety of causes have been reported in the literature, and are reviewed. Notably, musical hallucinations tend to occur secondary to temporal lobe insults and often are of a religious or patriotic theme.

PMID: 15624894

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

References