Overload

Diabetes mellitus

Category: Illness or disabilities

Type

Involuntary

Introduction and description

 

Diabetes mellitus is a type of Diabetes.  A person with Diabetes mellitus has high blood sugar.  It is generally a result of:

  • Damage to pancreas - Insulin is produced in the pancreas and is the hormone regulating glucose levels.  Low levels of circulating insulin, or its absence, will prevent glucose from entering cells, any cells.  If there is low insulin it can be because of the pancreas.  
  • Cell damage - Alternatively there may be a decrease in the sensitivity of cells to insulin, resulting in decreased glucose absorption.

In each case, there is 'cell starvation' and elevated blood glucose levels.  Thus there are two main types of diabetes mellitus:

  • Type 1 diabetes - Type 1 diabetes mellitus is caused by loss of the insulin-producing beta cells of the islets of Langerhans in the pancreas leading to insulin deficiency. This loss may be the result of incomplete development of the cells, damage to the cells or diseases of the cells.  Type 1 diabetes can affect children or adults.  This type of diabetes requires the person to inject insulin and became treatable when insulin became available in 1921, before that people would die.
  • Type 2 diabetes -  results from' insulin resistance', a condition in which 'cells fail to use insulin properly'. The defective responsiveness of body tissues to insulin is believed to involve the insulin receptor. I will have more to say about this belief by our medical profession shortly.  Type 2 diabetes is the most common type of diabetes. 
The UK Home Secretary Teresa May was diagnosed with type 1
diabetes in 2013 and has to inject herself with insulin twice a day.

Both type 1 and 2 are chronic conditions.  In 2000, according to the World Health Organization, at least 171 million people worldwide suffered from diabetes, or 2.8% of the population. Its incidence is increasing rapidly. Diabetes mellitus occurs throughout the world, but is more common (especially type 2) in the more ‘developed’ countries. 

In 2010, nearly 26 million people had diabetes in the United States alone.  The Centers for Disease Control termed the change an ‘epidemic’.  It has predicted that between 1 in 5, or 1 in 3 Americas will have diabetes by 2050.  Given the causes, I think these estimates may be on the conservative side and I am not scaremongering. 

Global estimates of the prevalence of diabetes for 2010 and 2030 - Shaw JE, Sicree RA, Zimmet PZ - Epidemiology, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia.
AIM: We estimated the number of people worldwide with diabetes for the years 2010 and 2030.
METHODS:  Studies from 91 countries were used to calculate age- and sex-specific diabetes prevalences, which were applied to national population estimates, to determine national diabetes prevalences for all 216 countries for 2010 and 2030. Studies were identified using Medline, and contact with all national and regional International Diabetes Federation offices. Studies were included if diabetes prevalence was assessed using a population-based methodology, and was based on World Health Organization or American Diabetes Association diagnostic criteria for at least three separate age-groups within the 20-79 year range. Self-report or registry data were used if blood glucose assessment was not available.
RESULTS: The world prevalence of diabetes among adults (aged 20-79 years) will be 6.4%, affecting 285 million adults, in 2010, and will increase to 7.7%, and 439 million adults by 2030. Between 2010 and 2030, there will be a 69% increase in numbers of adults with diabetes in developing countries and a 20% increase in developed countries.
CONCLUSION:  These predictions, based on a larger number of studies than previous estimates, indicate a growing burden of diabetes, particularly in developing countries.

Symptoms

Comedian and actor, Arthur Smith, developed
diabetes after a life-threatening bout of acute
necrotising pancreatitis in 2001.

The main signs and symptoms of diabetes mellitus are:

  • Polyuria – a large amount of sugary urine is excreted because the blood glucose concentration becomes so high that the kidneys are unable to reabsorb all the glucose filtered into the tubules back into the blood. 
  • Diabetic nephropathy, the impact of diabetes on the kidneys, can lead to scarring changes in the kidney tissue, loss of small or progressively larger amounts of protein in the urine, and eventually chronic kidney disease requiring dialysis.
  • Polydipsia  - In order to excrete the glucose, the kidneys use water to dilute the glucose and excrete it in the urine, this then leads to excessive thirst as the person tries to drink more and more water in order to help the kidneys excrete the sugars.  It is not uncommon for people with untreated diabetes to suffer from dehydration.
  • Polyphagia – the cells are not getting the glucose they need and the consequence is that the person has a craving for sweet things and more food to try to get the glucose the cells crave.  They will be always hungry, but also always tired.  As the brain uses glucose to help it to function, the person may also suffer badly from confused thinking because the brain is being starved of essential fuel.
  • Weight gain/weight loss - In Type 1 diabetes, the lack of insulin causes weight loss and muscle wasting because insulin also acts as a ‘body building’ hormone.
    Diabetes sufferer, Wendy Gaye
    But people with type 2 diabetes do not have a lack of insulin, instead their cells cannot process it, so the insulin in their blood functions normally.  Insulin has two additional functions besides that of a transporter of glucose into cells:
    • Insulin helped the body store excess glucose as ‘adipose tissue’. Insulin increases the rate of conversion of glucose to fat in fat storing cells [adipose tissue]
    • Insulin increased the rate of conversion of glucose to glycogen in the liver and muscle cells. Glycogen is used by the body as a sort of reserve supply of energy

But only a limited amount of glycogen can be stored in the body, beyond this limited amount the glucose is either excreted or turned to fat.  Thus where the body’s cells have lost their responsiveness to the glucose produced, the insulin tends to turn the excess glucose into fat – the person can become obese.

  • Cardiovascular disease - The massive amounts of glucose swishing about in the person’s blood vessels can also damage them over the longer term and produce hardening of the arteries and cardiovascular disease.  Diabetes  - excess glucose - doubles the risk of cardiovascular disease -  atherosclerosis of larger arteries and peripheral vascular disease, as well as "microvascular" complications—damage to the small blood vessels. Diabetic retinopathy, which affects blood vessel formation in the retina of the eye, can lead to visual symptoms, reduced vision, and potentially blindness.
    This same hardening of the arteries and other blood vessels also results in shortness of breath and all the other well known symptoms of cardiovascular disease.
  • George Lucas, the inventor of Star wars
    was diagnosed with type 2 diabetes in 1998
    Ketoacidosis – People with type 1 diabetes may also get ‘diabetic ketoacidosis’.  Ketoacidosis is a metabolic state marked by extreme and uncontrolled ketosis. In effect, the body perceives it cannot get the energy it needs from the glucose so it starts to use the body itself for fuel - the liver breaks down both fat and proteins in response to the perceived need for ‘respiratory substrate’ – fuel. In extreme cases ketoacidosis can be fatal. Ketoacidosis can be smelled on a person's breath. This is due to acetone, a direct byproduct of the spontaneous decomposition of acetoacetic acid. It is often described as smelling like fruit or nail polish remover. The person may also suffer from nausea, vomiting and abdominal pain; [and altered states of consciousness].
  • Diabetic neuropathy  - is the impact of diabetes on the nervous system, most commonly causing numbness, tingling and pain in the feet and also increasing the risk of skin damage due to altered sensation. Together with vascular disease in the legs, neuropathy contributes to the risk of diabetes-related foot problems (such as diabetic foot ulcers) that can be difficult to treat and occasionally require amputation.

Causes

 

 

Insulin is a naturally occurring hormone released by beta cells in the pancreas in response to food [or drink]. 

Thus anything that attacks the pancreas, or the liver with which it is closely associated is likely to produce diabetes. 

So this is one root cause, damage to the pancreas and liver.

The other main cause is damage to the cells.  There is a third root cause - the balance between the sympathetic nervous system and the parasympathetic nervous system.

Fight and flight - very impressive .....      

Norepinephrine is a neurotransmitter released from the sympathetic neurons.  An increase in norepinephrine from the sympathetic nervous system increases the rate of contractions in the heart.  It is part of the fight-or-flight-response and is released in times of stress, fear, danger, anxiety etc  to prepare us for the flight or the fight.  As we are unlikely to meet any dinosaurs or tyrannosaurus rexes in this day and age, we neither fight or flight, which means that our whole body becomes geared up to do something which doesn't happen.

 

Norepinephrine, along with epinephrine [adrenaline], directly increases heart rate, and triggers the release of glucose from energy stores, increasing blood flow to skeletal muscle.  The glucose will stay in our system much longer if we aren't actually doing anything to dissipate it - like fighting or flighting.  Whilst there it may do permanent damage to our cells.

Thus anything that causes us stress and fear - like the dentists, the doctors, the hospital ... is going to cause a massive rush of glucose in our blood stream, as such none of us may be suffering from diabetes at all, we are actually suffering from a well justified fear of doctors, or as the Americans say physicians.

Let us assume, however, that doctors, dentists, hospitals and the entire medical fraternity with the exception of healers are not the cause, what else have we got?

Stress

 

Continuous stress means continuous fight or flight response.  Continuous fight or flight response means high noradrenaline and adrenaline.  High noradrenaline means constantly swilling glucose in our blood stream, which after a while will simply destroy the cells or the ability of the cells to use it.  And this cell death occurs all over the place............

Type 2 diabetes (T2D) is a complex metabolic disorder characterized by hyperglycemia in the context of insulin resistance, which precedes insulin deficiency as a result of β-cell failure. Accumulating evidence indicates that β-cell loss in T2D results as a response to …. stress. Failure of the ER's adaptive capacity and further activation of the unfolded protein response may trigger macroautophagy (hereafter referred as autophagy) as a process of self-protection……. Many studies have shown that inflammation plays a very important role in the pathogenesis of T2D. Inflammatory mechanisms and cytokine production activated by stress … may further alter the normal structure of β-cells by inducing pancreatic islet cell apoptosis. ….. Therapeutic approaches aimed at ameliorating stress and inflammation may therefore prove to be promising targets for the development of new diabetes treatment methods. PMID:  24520198

Like warm baths and loving dogs.... see Suppression.

Pharmaceuticals

 

Any pharmaceuticals that release norepinephrine on a permanent basis inhibit insulin and raise blood glucose levels, including release agents and reuptake inhibitors.   

Stimulants - Norepinephrine is often released by pharmaceutical drugs used in the treatment of ADHD - attention-deficit/hyperactivity disorder, depression, anxiety, schizophrenia, manic depression, narcolepsy, obesity and hypotension. So as we can see there is a long term risk of diabetes from:

eHealthme:  On Oct, 21, 201671,963 people reported to have side effects when taking Paxil. Among them, 1,350 people (1.88%) have Diabetes Mellitus

and

eHealthme:  On Oct, 22, 2016,53,621 people reported to have side effects when taking Prozac.  Among them, 1,136 people (2.12%) have Diabetes Mellitus

and perhaps the most impressive of all

eHealthme:  On Oct, 17, 2016,78,253 people reported to have side effects when taking Seroquel.  Among them, 11,322 people (14.47%) have Diabetes Mellitus

Pharmaceuticals that compromise the immune system - But numerous pharmaceuticals also destroy gut flora and interfere with the protective defence systems in our body, the stomach acid and the enzymes that process food, for example.  In some cases [like the statins] they interfere with the cell repair cycle thus preventing any repair work needed as a result of attack.  By doing this they enable viruses, bacteria, fungi, parasites, food particles [including sugars] and other toxins such as heavy metals to enter the system. All these attack organs and one of the organs they attack is the pancreas.

Tom Hanks' doctor told him he had diabetes
type 2 -but then again...

The eHealthme site has now established an extremely impressive list of pharmaceuticals that cause diabetes mellitus - hundreds and hundreds - and this is because so many attack our natural immune defences.  These are not anecdotal reports they are reports submitted as Adverse Drug reports to the FDA and SEDA.  

  • Follow the LINK to the eHealthme website
  • Using the ‘All conditions’ index find the appropriate entry
  • Now scroll down until you get to the section marked ‘Drugs that could cause

As of October 2016, about 2,050 pharmaceuticals were in this list.  Very high numbers of adverse drug reports seem to exist for

  • Antipsychotics
  • Asthma and COPD treatments
  • Insomnia treatments
  • Epilepsy treatments
  • NSAIDs and pain killers - including ones we might regard as 'harmless' like Ibuprofen and aspirin
  • Statins - which have a truly impressive record of producing diabetes
  • Benzodiazepines
  • Anti-diabetes drugs - yes believe it or not some drugs actually make the diabetes worse, there are literally thousands and thousands of adverse drug reports from many drugs in this category and with no particular type of drug being especially more prevalent than the others, although many of the anti-diabetic drugs from the sulfonylurea class seem to be particularly prominent.  Newer ones appear all the time - like the insulin analogues, for example [Metformin is a drug supposedly used to treat diabetes not give it to you]

eHealthme:  On Oct, 18, 2016,  91,548 people reported to have side effects when taking Metformin.  Among them, 1,614 people (1.76%) have Diabetes Mellitus

Diabetes mellitus and cancer are common conditions, and their co-diagnosis in the same individual is not infrequent.. ….. Evidence from observational studies suggests that …. drugs used to treat cancer may either cause diabetes or worsen pre-existing diabetes. PMID:  25044584

There are more, but you can find the complete list on eHealthme of the actual drugs, this should give a flavour for just how many are implicated by ADRs, which in all cases will be but the tip of the iceberg, as there will be numerous doctors who do not bother to report, or who never make the link between the drugs and diabetes.

 This is but one example of the statin effects from eHealthme

eHealthme: On Oct, 21, 2016, 177,999 people reported to have side effects when taking Lipitor.  Among them, 3,002 people (1.69%) have Diabetes Mellitus

Oxazolines: - Another class of pharmaceutical known to have the effect of releasing norepinephrine on a permanent basis inhibit insulin release via α2-receptors -  are the

Halle Berry, was in a coma for a week
and was told that she had type 1 diabetes

Oxazolines: such as  Clominorex, Cyclazodone, Fenozolone, Fluminorex, Pemoline or  Thozalinone.

  • Pemoline is a stimulant drug sold under the trade names Betanamin, Cylert, Tradon, and Ceractiv it was used as a medication to treat attention-deficit hyperactivity disorder (ADHD) and narcolepsy.  "It is no longer generally available in the United States as a result of the FDA withdrawing approval of pemoline as an indicated treatment for ADHD, due to its implication in liver failures among children who were receiving the medication".
  • Clominorex is sold as an 'appetite suppressant', as is Fluminorex
  • Cyclazodone is a centrally acting stimulant drug developed by American Cyanamid Company in the 1960s.  It is a banned stimulant under the World Anti-Doping Agency prohibited list, which means it is still available
  •  Fenozolone (Ordinator) was developed by Laboratoires Dausse in the 1960s and is a 'psychoactive drug and stimulant' which acts as a norepinephrine-dopamine releasing agent (NDRA).
  • Thozalinone (Stimsen) is a psychostimulant that has been used as an antidepressant in Europe. It has also been trialed as an anorectic. "Thozalinone likely acts [sic] via inducing the release of norepinephrine and dopamine as with its analogues pemoline and aminorex"

Finally we have one last class of pharmaceuticals which have a heady record for producing diabetes - Glucocorticoids (GC).

Tommy Lee- The Mötley Crüe drummer has type 2 diabetes

Immunosuppressants - Glucocorticoids (GC) are a class of steroid hormones that bind to the glucocorticoid receptor (GR), which is present in almost every human cell. The name glucocorticoid (glucose + cortex + steroid) derives from their role in the regulation of the metabolism of glucose, their synthesis in the adrenal cortex, and their steroidal structure.  Cortisol (or hydrocortisone) is the most important human glucocorticoid. It regulates or supports a variety of important cardiovascular, metabolic, immunologic, and homeostatic functions.

Various synthetic glucocorticoids are also available.  Synthetic GCs are used either as replacement therapy in glucocorticoid deficiency or to suppress the immune system. GCs are part of the feedback mechanism in the immune system that turns immune activity (inflammation) down.  In the flawed and mistaken belief that the immune response is somehow acting incorrectly, this class of drugs are used for illnesses and I quote which " are caused by an overactive immune system, such as allergies, asthma, autoimmune diseases, Crohn's disease, ulcerative colitis, various skin disorders such as psoriasis and eczema and sepsis".  Except that none of these diseases is caused by 'an over active immune system', they are caused by a pathogen unidentified by the medical fraternity, which the immune system is doing its level best to deal with.

Glucocorticoid drugs currently being used act nonselectively, so in the long run they impair many healthy anabolic processes.  And one of the principle side effects experienced with GCs include hyperglycemia due to increased gluconeogenesis, insulin resistance, and impaired glucose tolerance – leading to diabetes.  For example

eHealthme:  On Oct, 19, 2016,  139,345 people reported to have side effects when taking Prednisone.  Among them, 1,489 people (1.07%) have Diabetes Mellitus

Waxed fruit and vegetables, chocolate candies, dental floss and vitamin pills

 

Any pharmaceuticals that release norepinephrine on a permanent basis inhibit insulin release via α2-receptors.   Another class of chemicals that do this are the Morpholines such as Fenbutrazate, Morazone and Phendimetrazine. 

The name will be meaningless to most people but morpholines are used by the food industry. 

Morpholine is used as a chemical emulsifier in the process of waxing fruit. Naturally, fruits make waxes to protect against insects and fungal contamination, but this can be lost as the fruit is cleaned. A small amount of new wax is applied to replace it. Morpholine is used as an emulsifier and solubility aid for shellac, which is used as the wax for fruit coating.  The European Union has forbidden the use of morpholine in fruit coating, but other countries haven't.

Taking drugs

 

When is a drug a drug and when is it a pharmaceutical?  The definition over time has often been arbitrary - in the past we have been prescribed cocaine for toothache, opium for teething pains, LSD for psychological problems.  So the dividing line is meaningless - some drugs are sold to you by dealers on the streets and some drugs are sold to you in so called health food stores and some drugs are sold to you by the drug dealers we know as doctors as part of the approach known as symptom based medicine - mask the symptom don't find the cause.

Any illegal drug can also be a legal drug when sold to you by a doctor.  ADHD drugs are amphetamines.  So what remains of the pharmaceuticals that release norepinephrine on a permanent basis, thereby inhibiting insulin release via α2-receptors?  The main ones are:

  • Phenethylamines - amphetamines, cathinones, phentermines, etc such as  Amphetamine (Dextroamphetamine, Levoamphetamine) ,  BDB,  BOH,  Butylone,  Cathine,  Cathinone, Clobenzorex, Ephedrine, Ethcathinone, Hordenine,  MBDB, MDA, (Tenamfetamine), MDEA, MDMA, MDMPEA, MDOH, MDPEA, Mephedrone,  Methamphetamine (Dextromethamphetamine, Levomethamphetamine),  Methedrone, Pseudoephedrine 
  • Piperazines: such as 2C-B-BZP, BZP, MBZP, etc and of course lest we forget ....

Toxins

Toxins are implicated in diabetes in a rather complex cause effect chain, which may be difficult to prove using the current mechanisms of research which rely largely on heuristical evidence and not logic based analysis of the process involved.  There are papers on PubMed which implicate all the usual suspects such as insecticides, fungicides, dioxins, heavy metals, pesticides and so on, but in some senses these use the same heuristical approach.

 

This is crude science and one would have hoped we had moved on beyond the 'red sky in the morning shepherd's warning' methods of connecting things, which are still little better than superstition, and in many cases a good deal worse, as in the olden days it took far more shepherds to come up with theories than it appears to need for science to think it has found the answer.

Using the process based approach to detemining cause and effect, any toxins that enters the blood stream via the intestine, lungs, stomach or nose, for example can damage the pancreas or liver.  In order for those toxins to have got into the blood stream, the immune system defences must have been breached.  At overdose levels this can happen - so we have a short cause effect chain here.  But even at smaller doses, if the immune system has been compromised by pharmaceuticals, nutritional deficiency, radiation, [and so on, other means do exist] then the toxins can enter the system. 

Note that dental amalgam fillings may be a risk factor if there has been poor dental work coupled with for example gingivitis allowing entry of mercury from bleeding gums. Mercury is an insulin mimic.

Long term exposure to inhaled lead via 'gas guzzler' cars can do much the same damage, as can short or longer term high levels of lead exposure.  A bit of heuristical research now .........

The mortality pattern of taxi drivers in Rome as possibly exposed mainly to gasoline engine exhausts [and lead] was evaluated by means of a historical cohort study. A total of 2,311 male subjects registered as taxi drivers between 1950 and 1975 was followed from 1965 through 1988. …. the number of recorded deaths for malignant neoplasms was about the expected (205 deaths). …. Diabetes was significantly increased (42 deaths).  PMID:  7516624

One toxin is of course the smoke from cigarettes, but this is the least of our worries these days given the number of toxins released into the environment.

Another source of mercury is the Thiomersal in some Vaccines of which more shortly.

Viruses

While training for the 2002 Olympics, cross-country
skier Kris was diagnosed with type 1 diabetes

A vast and increasing number of viruses are being implicated in the development of diabetes types 1 and 2.  The viruses attack cells in such a way that they don't respond to either insulin or glucose and thus insulin can be left unused or glucose.  Alternatively the viruses attack the insulin producing mechanisms in the body, the pancreas and liver meaning they malfunction.  For example

Enteroviruses (EVs) have been connected to type 1 diabetes in various studies. The current study evaluates the association between specific EV subtypes and type 1 diabetes by measuring type-specific antibodies against the group B coxsackieviruses (CVBs), which have been linked to diabetes in previous surveys. Altogether, 249 children with newly diagnosed type 1 diabetes and 249 control children matched according to sampling time, sex, age, and country were recruited in Finland, Sweden, England, France, and Greece between 2001 and 2005 (mean age 9 years; 55% male). Antibodies against CVB1 were more frequent among diabetic children than among control children (odds ratio 1.7 [95% CI 1.0-2.9]), whereas other CVB types did not differ between the groups. CVB1-associated risk was not related to HLA genotype, age, or sex. Finnish children had a lower frequency of CVB antibodies than children in other countries. The results support previous studies that suggested an association between CVBs and type 1 diabetes, highlighting the possible role of CVB1 as a diabetogenic virus type.  PMID:  24009257

and

Diabetes mellitus type 2 is a metabolic disorder characterized by high blood glucose due to insulin deficiency or resistance. Alzheimer's disease (AD) is a complex neurodegenerative disease leading to irreversible loss of neurons, intellectual abilities, memory and reasoning. ….. The association of virus infection in type 2 diabetes mellitus and AD has been reported in few recent studies, some have shown direct evidence of virus infection in diabetes and AD while other have shown that diabetes increases the risk of developing AD. This review aims to summarize the association of a few common viruses like Hepatitis C Virus and Herpes Simplex Virus-1 which affects both these two age-related devastating diseases. We also discuss the pathological links of Influenza virus, Cytomegalovirus, West Nile virus, Enterovirus, Herpes Simplex Virus-2, Hepatitis viruses in diabetes and Influenza virus, Picornavirus and Borna disease virus in AD. Establishing such relationships and defining their common pathogenesis and patho-physiological mechanisms may lead to new concepts and paths for developing novel preventive strategies … for diabetes and AD. This study may aid in future for the identification of a single or a panel of likely blood-based viral biomarkers for early diagnosis of diabetes and AD with high sensitivity and specificity.  PMID:  24059298

There are many more papers like this on PubMed implicating numerous viruses, as such we may find in the long term that it will be easier to list the viruses that don't cause diabetes than those that do.

For the viruses to have entered the immune system must have been compromised.

Vaccines

 There are three main ways in which vaccines may cause diabetes.

1.  Live viruses and bacteria

Where the vaccine used in the injection is a live virus or bacteria, there are instances where it, although apparently vanquished by the immune system, lays low and continues to attack, albeit at a much reduced rate.  One example is the herpes virus, read on:

Herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2) are human neurotropic viruses that establish latent infection in dorsal root ganglia (DRG) for the entire life of the host. From the DRG they can reactivate to cause human morbidity and mortality. Although they vary, in part, in the clinical disorders they cause, and in their molecular structure, they share several features that govern the biology of their infection of the human nervous system. The biology of their ability to establish latency, maintain it for the entire life of the host, reactivate, and cause primary and recurrent disease is being studied in animal models and in humans.  PMID: 24142852

This is not the only virus to do this. 

Dig Liver Dis. 2014 Jun;46(6):574-5. doi: 10.1016/j.dld.2014.02.005. Epub 2014 Mar 14.  Acute Epstein-Barr virus pancreatitis with thoracic-abdominal abscess and portal compression.  Galzerano A1, Nisi F2, Angela S3, Ranucci F1.PMID:  24630949

thus any vaccine containing a live virus carries great risk with it.

2.  Thiomersal

Some vaccines contain Thiomersal, which is mercury based.  For a full list see this LINK.  As a consequence, there is the risk of mercury poisoning and mercury poisoning can cause diabetes as well as blindness and sight degeneration.

3.  Vaccine excipient

Vaccines contain three main substances. 

  • The agent is the active virus or bacteria against which we are being vaccinated
  • The adjuvant is a booster which tells the immune system to fight like a thing possessed against anything in the vaccine - agent adjuvant and excipient
  • The excipient is like a sort of holding fluid for the other two.  It contains stuff for the virus to feed on, preservatives to give the vaccine a long shelf life, plus other things

And some vaccines contain sugars  .... in fact some vaccines contain glucose and substances just like glucose.  Here is the LINK to the Wikipedia entry showing the contents of vaccines.  What do we find?  Well some examples of the vaccines containing sugars include:

  • Adenovirus vaccine
  • DTaP/Hib (TriHIBit)
  • Hib vaccine (ACTHib)
  • Influenza vaccine (FluMist)
  • MMR vaccine (MMR-II)
  • MMRV vaccine (ProQuad)
  • Rotavirus vaccine (RotaTeq)
  • Rotavirus vaccine (Rotarix)
  • Typhoid vaccine (oral – Ty21a/Vivotif)
  • Varicella vaccine (Varivax) - - chicken pox and shingles vaccine
  • Zoster vaccine (Zostavax) - chicken pox and shingles vaccine

What is the vaccine telling the immune system to do?  'Fight the contents of the vaccine develop an immune response every time you come into contact with this substance'.  So what does the immune system do when we eat anything that produces sugars that enter the blood stream? The immune system responds.  It is doing exactly what it was told to do - a perfect response - it fights the substance and the way it appears to do it is by closing off every cell to ensure the substance does not get in. 

So we are left with unused  glucose swilling around our system, starved cells, and weakness of an unimaginable seriousness and .......

  • Kidney failure - Since the kidneys have the job of getting rid of all this glucose but themselves will be weakened by a lack of fuel
  • Brain failure - Oh yes, and as the brain uses glucose to help it to function, the person may also suffer badly from confused thinking because the brain is being starved of essential fuel, this will look like dementia.
  • Blindness - Oh yes, and since the eyes are based on cells too - blindness.
  • Heart failure - Oh yes, and  since our heart is a cell based organism eventually probably sooner rather than later - heart failure.

Nuff said

 

Nutritional deprivation

 

In many of the developing countries where food is of poor quality or low in minerals and vitamins - like the USA [sorry I jest - or maybe I don't], nutritional deprivation in children can result in malformation of the pancreas. 

Chronic pancreatitis is defined by a persistent destruction of the pancreatic parenchyma replaced by fibrosis. The lesions generally start in the exocrine gland, islets being attacked later in the fibrosis. The two most frequent forms are:

1. Chronic calcifying pancreatitis which is a pancreatic lithiasis responsible for more than 95% of chronic pancreatitis. In its most frequent form, calculi are built up of more than 98% calcium salts together with fibres of a degraded residue of lithostathine, a secretory protein. This disease is related in most countries to alcohol, protein, fat and tobacco and in certain tropical countries to malnutrition (low-fat, low-protein diet).
The mechanism of calcium precipitation is partly explained by the calcium-saturation of pancreatic juice and the decreased biosynthesis of lithostathine S, the secretory protein preventing crystallization. As a rule, diabetes appear after a clinical evolution characterized by recurrent attacks of upper abdominal pain.

2. Obstructive pancreatitis is due to an obstacle (tumours, scars) in the pancreatic duct. It is rarely a cause of diabetes.

PMID: 1445167

It also appears, however, that mineral and vitamin supplements also have a very clear record for producing diabetes, presumably at overdose levels, for example, the following is from eHealthme, note that the trend is increasing as one would expect as these drugs take a while to do the damage:

On Oct, 27, 2016: 104,383 people reported to have side effects when taking Folic Acid.
Among them, 617 people (0.59%) have Diabetes Mellitus

and

eHealthme:  On Nov, 14, 2016:  13,816 people reported to have side effects when taking Vitamins.  Among them, 205 people (1.48%) have Diabetes Mellitus

Better to have the spinach .....

One known mineral which does truly severe damage to the pancreas in excess is iron.  Researchers have dubbed the problem 'iron overload' - an accumulation of iron in the body from any cause. I have called it iron imbalance.  The two most common causes of iron overload are iron tablets and lack of roughage in the diet [an excess of bran is just as bad incidentally - moderation in all things].  

It is very easy to overdose on iron supplements.  Both adults and children can be poisoned by 'over consuming' ferrous sulfate tablets. This is one of the most common toxicological causes of death in children under six and one of the most common causes of diabetes.  Bran in its natural form, serves to remove excess iron and zinc, now anyone who eats only 'refined' foodstuffs is at risk from overdosing on iron [and zinc].

Clearly overdosing on sugary or glucose filled food and drinks, is going  to put an enormous strain on the system and eventually kill off the receptors that are used for the intake of glucose into the cells.  If we overdose on anything, the body adjusts the number of receptors to cope.  Once we reduce the amount of sugar, or the foods that supply sugar - glucose - then we are in a sense suffering from withdrawal symptoms because our cells have become adjusted to deal with the overdose levels.   This is why people get sugar cravings - sugar is like a drug in this respect.  Crash diets are dangerous for this reason, the cells become totally starved of any input [not enough receptors for the glucose] and you could easily die of heart failure.  All adjustments to food type and intake needs to be gradual so that the body can readjust gradually.

Parasites

This lady had a stroke and her cat 'saved her', but
parasites cause strokes too.  Cats .... a curse and
a blessing

There are literally hundreds of parasites and depending on the site and circumstances of infection, they can get everywhere from the intestine to the brain, from the lungs to the pancreas.  And they do, in high numbers.  Their presence is known from cysts, which form around the parasites if your immune system is working well.  But the presence of cysts is a sure indicator of damage.

Through a case-control study, overall 184 serum samples including 91 from diabetic cases and 93 from healthy non-diabetic controls were investigated. Cases and controls were matched for age and gender. Serum samples were tested for sugar by an enzymatic method, and IgG antibodies were tested against Toxoplasma gondii by ELISA method...... Risk of toxoplasmosis infection in diabetic patients with was two folds higher than healthy controls  CONCLUSIONS:  Diabetes may be caused by Toxoplasma gondii. Presence of T. gondii in the pancreas at the same time could directly undermines the pancreas cells. When β cells are destroyed, insulin secretion would then be affected.  PMID: 24578838

Toxoplasmosis is a parasitic disease caused by the protozoan Toxoplasma gondii. The parasite infects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family - see Being with cats.

Another serious carrier of parasites is the fox which spreads Echinococcosis.  In countries where dogs and cats are not wormed and their faeces safely disposed of, domestic dogs and cats can also be a problem.  This parasite can also cause brain damage [strokes, dementia, haemorhages, tumours] and blindness.

Fungal infection

Up until recently there were few studies done on post mortem patients of the pathogens infecting and causing pancreatic damage.  All this has changed and a significant body of evidence is emerging of the role of fungi plus parasites, viruses and bacteria - of which more shortly.  Here is but one example of many

Data on the microbial spectrum in infected pancreatic necrosis are scarce. ... The present study evaluated the microbial spectrum of infected pancreatic necrosis and the possible relationship between infected necrosis, organ failure, and mortality. Furthermore, we investigated whether the aetiology of pancreatitis, use of external drainage, and antibiotic treatment influenced the microbial findings.
METHODS:  Retrospective review of medical charts on 78 patients who underwent ETDN in our tertiary referral centre between November 2005 and November 2011.
RESULTS:  Twenty-four patients (31%) developed one or more organ failures, 23 (29%) needed treatment in the intensive care unit (ICU), and 9 (11%) died during hospital admission. The prevailing microbial findings at the index endoscopy were enterococci (45%), enterobacteriaceae (42%), and fungi (22%). There was a significant association between the development of organ failure (p < 0.001), need of treatment in ICU (p < 0.002), in-hospital mortality (p = 0.039) and infected necrosis at the time of index endoscopy. Enterococci (p < 0.0001) and fungi (p = 0.01) were found more frequently in patients who died during admission as compared to survivors.
CONCLUSION:  Different microbes in pancreatic necrosis may influence the prognosis. We believe that a detailed knowledge on the microbial spectrum in necrotizing pancreatitis may be utilized in the treatment to improve the outcome. PMID: 25266641

Enterococcus is a genus of lactic acid bacteria of the phylum Firmicutes.  The Enterobacteriaceae are a large family of Gram-negative bacteria that includes many of the more familiar pathogens, such as Salmonella, Escherichia coli, Yersinia pestis, Klebsiella and Shigella. Other disease-causing bacteria in this family include Proteus, Enterobacter, Serratia, and Citrobacter.  Which brings us on neatly to the next cause - bacteria.

Bacterial infection

There are very clear links between pancreatic damage and bacterial infection.  Thus bacteria are another cause [though as should be clear, not the only one].

All patients with chronic pancreatitis who underwent operation from November 2011 to October 2013 were prospectively included in the study. .....
A total of 26 patients were analyzed. .. Bacteria was present in pancreatic duct fluid in 11 (42%) patients. ...Most common organism observed was Escherichia coli (6/11, 55%) followed by Klebsiella pneumonia (3/11, 27%). Five patients with positive culture developed wound infection. Bacteria isolated from the wound were similar to pancreatic fluid.
Bacteria is commonly present in the pancreatic juice in patients with chronic pancreatitis …..Role of bacteria in the pathogenesis of the chronic calcific pancreatitis needs to be investigated in future studies.  PMID:  25262715

 Radiation

All radiation whether 'cosmic' or electromagnetic impacts our bodies and depending on its frequency it resonates different parts of us.  The reason that nuclear radiation is so dangerous is that it impacts cells, but what we appear to have overlooked is that all radiation impacts some part of us.

Every aggregate in our bodies - organs, cells, the body itself, has natural ‘resonance’.  Resonance is a substance’s natural tendency to oscillate – vibrate – at maximum amplitude at certain frequencies, known as the thing’s resonant frequency.

And long term exposure at the resonating frequency, or short term high intensity exposure to the resonating frequency of the insulin receptors on cellsleads to their death.

Physical injury and surgery

 

Injury as a result of some form of physical trauma or surgery which affects the pancreas or liver may result in damage to the insulin producing cells.  Note that damage may be a by-product of surgery to other organs - a form of friendly fire.  Gastric by-pass surgery, even heart surgery, which involves the removal of the rib cage,  has been known to result in damage to the pancreas.

Removal of the gall bladder, which itself is risky, and results in the compromising of the immune system, can cause damage.  I have not put 'unnecessary removal' of the gall bladder, because removal of the gall bladder is nearly always unnecessary.

Peter O'Toole underwent surgery in 1976 to have his

pancreas and a large portion of his stomach removed,

which resulted in insulin-dependent diabetes

The gall bladder is where bile is stored, before it is released into the small intestine. Without bile the intestinal flora and protective defences of the intestine are compromised.  Wikipedia that fount of all human knowledge says "Humans can live without a gallbladder", what they have not added is the key phrase "but not for long".

Genetic damage

Geneticists, because they are geneticists, are keen to link diabetes with inherited genes and gene damage.   And indeed the genes of some babies are severely damaged in the womb by all the things in the list above - fungi, parasites, viruses, bacteria, toxins, heavy metals, and pharmaceuticals.  But there is one truly nasty toxin which appears to be particularly key to genetic damage -  the nanoparticle - invented by scientists and being released into the environment by scientists in the belief that they do no harm, except that yet other researchers have realised they do a lot of harm......

....DNA damage occurs chemically or physically by nanomaterials. Chemical and physical damage are associated with point mutation by free radicals and double strand brake, respectively. The failure of DNA repair and accumulation of mutations might occur when inflammation is prolonged, and finally normal cells could become malignant. These free radicals can not only damage cells but also induce signaling molecules containing immunoreaction. Nanoparticles and asbestos also induce the production of free radicals. .... Taken together,... a variety of diseases [may be] induced by nanomaterials. PMID: 25097864

Genetic engineering of humans on a vast scale.

Treatment

Find the CAUSE

References and further reading

Papers

  • Impact of videogame playing on glucose metabolism in children with type 1 diabetes -Phan-Hug F, Thurneysen E, Theintz G, Ruffieux C, Grouzmann E - Endocrinology-Diabetology Unit, Department of Paediatrics, University Hospital, Lausanne, Switzerland  Abstract ...This pilot study suggests that VG playing could induce a state of excitation sufficient to activate the sympathetic system and alter the course of glycemia. Dietary and insulin dose recommendations may be needed to better control glycemic excursion in children playing VG

 Video

This is a wonderful video Peter Attia: Is the obesity crisis hiding a bigger problem?

 

Observations

All the observations for diabetes mellitus have been grouped under the general heading of diabetes, as, although scientific papers are usually precise about which form is being described, people simply say they have 'diabetes'.

 

Related observations