Suppression

Resveratrol

Category: Natural chemicals

Type

Voluntary

Introduction and description

description shortly

 

 

Dr Duke’s list of activity for RESVERATROL

 

Activity

*Reference

5-HETE-Inhibitor IC50=3-9 uM

*

5-HT-Inhibitor IC50=3-9 uM

*

5-Lipoxygenase-Inhibitor IC50=1-9 uM

*

5-Lipoxygenase-Inhibitor IC50=48 uM

*

Akt-Inhibitor

*

Antiaggregant IC50=0.016-232 uM/L

*

Antiaggregant IC50=100 uM

*

Antiangiogenic

*

Antibacterial

*

Anticancer

*

Anticarcinogenic

*

Antiedemic ED50

*

Antieicosanoid

*

Antiinflammatory IC50=2.6 uM

*

Antileukemic 15-30 uM

*

Antileukotriene IC50=1.37 uM

*

Antilipoperoxidant IC50=2 mg/L

*

Antimutagenic ED50=4 uM

*

Antioxidant IC50=2 mg/L

*

Antioxidant 2 x Vit. E

*

Antiperoxidant

Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.

Antiproliferant

*

Antiprostaglandin IC50=2.6 uM

*

Antiradicular ED50=27 uM

*

Antiseptic

*

Antithrombic IC50=100 uM

*

Antitumor

*

Antitumor (Mammary) ED50=3.1 uM

*

Antitumor (Prostate) 25 uM

*

Antitumor (Skin) ID68=1 uM

*

Antitumor (Skin) 5+ uM

*

Apoptotic IC50=15-30 uM

*

Artemicide

*

Beta-Glucuronidase-Inhibitor IC50=~25 uM

*

Cardioprotective

*

Casein-Kinase-II-Inhibitor

*

Chemopreventive

*

COX-1-Inhibitor ED50=15 uM

*

COX-1-Inhibitor 50 uM/

Jang, M. S., Pezzuto, J. M. 1998. Resveratrol Blocks Eicosanoid Production and Chemically-Induced Cellular Transformation: Implication for Cancer Chemoprevention. Pharm Biol Suppl, 36: 28-34.

COX-2-Inhibitor 50 uM/

*

COX-2-Inhibitor >2.5->22.5 uM

*

COX-2-Inhibitor 50 uM/

*

Cyclooxygenase-Inhibitor IC50=15 uM

*

CYP1A1-Inhibitor

*

Differentiator IC50=18 uM

*

Elastase-Inhibitor IC50=37 uM

*

Estrogenic 22% of genistein

*

Fungicide

Chemical Constituents of Oriental Herbs (3 diff. books)

Hepatoprotective

*

HIF-1alpha-Inhibitor

*

Hydroperoxidase-Inhibitor

*

Hypocholesterolemic

*

Hypotriglyceridemic

Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.

IKB-kinase-Inhibitor

*

JNK-Inhibitor

*

Lipolytic

Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.

MAPK-Inhibitor

*

NADH-Ubiquinone-Oxidoreductase-Inhibitor

*

NF-kB-Inhibitor

*

Ornithine-Decarboxylase-Inhibitor

*

Pesticide

*

Phytoalexin

*

PKC-Inhibitor

*

PKD-Inhibitor

*

PTK-Inhibitor 110-263 uM

*

Quinone-Reductase-Inducer ED100=21 uM

*

Topoisomerase-II-Inhibitor IC50=49 uM

Sun, N. J., Woo, S. H., Cassady, J. M., Snapka, R. M. 1998. DNA Polymerase and Topoisomerase II Inhibitors From Psoralea corylifolia. J Natural Products, 61: 362-366.

VEGF-Inhibitor

*

 

*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

 

Related observations