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Resveratrol is cidal to both classes of Haemophilus ducreyi

Identifier

023252

Type of Spiritual Experience

Background

A description of the experience

Int J Antimicrob Agents. 2013 May;41(5):477-9. doi: 10.1016/j.ijantimicag.2013.02.008. Epub 2013 Mar 28.

Resveratrol is cidal to both classes of Haemophilus ducreyi.

Nawrocki EM1, Bedell HW, Humphreys TL.  1Allegheny College Department of Biology, Meadville, PA 16335, USA.

Abstract

Resveratrol, a polyphenolic phytoalexin, is produced by plants in response to infection and has antibacterial activity. Haemophilus ducreyi is a Gram-negative bacterium that is the causative agent of the sexually transmitted disease chancroid.

This study employed minimum cidal concentration (MCC) assays to evaluate the potential of resveratrol as a microbicide against H. ducreyi. Five class I and four class II strains of H. ducreyi tested had MCCs ≤500 μg/mL. Resveratrol was also tested against Lactobacillus spp., part of the natural vaginal flora.

Representative strains of Lactobacillus were co-cultured with H. ducreyi and 500 μg/mL resveratrol; in all cases, Lactobacillus was recovered in greater numbers than H. ducreyi. These results show that resveratrol is not only bacteriostatic but is bactericidal to H. ducreyi, confirming the compound's potential for use as a topical microbicide to prevent chancroid.

Copyright © 2013 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

PMID:  23541304

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Activities

Overloads

Chancroid

Suppressions

Resveratrol

Commonsteps

References