Adenosine

Category: Natural chemicals

Type

Involuntary and voluntary

Introduction and description

Adenosine is an 'endogenous purine nucleoside' in other words it is a chemical that occurs naturally in our bodies.

One of its functions appears to be as an anti-inflammatory and immunological messenger. If we get cellular damage, adenosine leaps to the rescue, triggering the autoimmune system and reducing inflammation. It is also important in regulating the heart. If adenosine is prevented in some way from getting to its receptors, we can get atrial fibrillation – heart flutter, so it is a sort of regulating messenger protecting the heart from stress and emotional upset.

As such we can see Adenosine is a part of the parasympathetic nervous system. It thus has a key role to play in relaxation as we cannot relax if our immune system has been compromised or our heart is all a flutter. In effect, We can think of it as one of a group of chemical counterparts to the technique of relaxation.

This means that we must also expect an effect on the lungs, which may appear negative out of context, but is simply a feature of the fact the body is adjusting to the relaxed state and needs less oxygen. Adenosine contributes to 'bronchoconstriction'.

Background

In human beings, there are four adenosine receptors. Each is encoded by a separate gene and has different functions, although with some overlap.

• Receptor A1 – The adenosine A1 receptor has been found to be ubiquitous throughout the entire body. This receptor has an inhibitory function on most of the tissues in which it is expressed. In the brain, it slows metabolic activity. Receptors found on the heart decrease heart rate, regulating myocardial oxygen consumption and coronary blood flow This receptor has other important roles in the brain, regulating the release of other neurotransmitters such as dopamine and glutamate
• Receptor A2A – these receptors help in regulating myocardial oxygen consumption and coronary blood flow. The A2A receptor regulates myocardial blood flow by vasodilating the coronary arteries, which increases blood flow to the myocardium, but may lead to hypotension. Just as in A1 receptors, this normally serves as a protective mechanism, “but may be destructive in altered cardiac function”
• Receptor A2B – this receptor is located mainly peripherally and is involved in processes such as inflammation and immune response. I’m afraid the description given was meaningless to me but I will repeat it here “This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation” Via a very long chain of effects, they also seem to play a part in bronchoconstriction and bronchospasm
• Receptor A3 –this receptor is also located mainly peripherally and is involved in processes such as inflammation and immune response. It is “cardioprotective in cardiac ischemia, and promotes inhibition of neutrophil degranulation”. It also “inhibits growth in human melanoma cells”

Antagonists

The naturally occurring chemical that counteracts Adenosine in our bodies is called Xanthine. Clearly in order to create a balanced system we need both Xanthine and Adenosine. Derivatives of Xanthine can be found in plants.

If you really go overboard on any antagonist, it will stimulate heart rate, force of contraction, cardiac arrhythmias at high concentrations. In high doses they can lead to convulsions that are resistant to anticonvulsants and you could die.

But their antagonistic action means they can have some positive effects in that they can help to relax bronchial smooth muscle. In asthmatic people or people with other lung disorders this can be a great help. 

Method

How it works

At the moderate to low doses one would expect during suppression, Adenosine itself and its ligands works via exactly the same mechanisms as the technique of relaxation. In the first place they should slow the brain down, as such it will have an effect on memory and reason thus helping to still the chattering mind and the intellect.

Once memory and reason have been temporarily stilled, the emotions have in part been quieted, input from the 5 senses and the nervous system minimised then the composer can step in and we get our spiritual experience.

The effects of overdose are described in the appropriate drug sections within the overdose section

List of plants containing ADENOSINE

According to Dr Duke's database

Related observations

Healing observations

• Adenosine and asthma 005301
• Dr Duke's list of myorelaxant activity in Celery 012451
• Dr Duke's list of sedative activity in Celery 012450
• Dr Duke's list of vasodilatory activity for Celery 012449
• Dr Duke's list of vasodilatory plant chemicals 010314
• Dr Duke’s list of Chemicals and their Biological Activities in: Cucurbita pepo L. (Cucurbitaceae) -- Zucchini 027494
• Healing anxiety disorders 005299
• Immune and inflammatory disease control 005300
• Instenon and children with brain dysfunction 005769
• Limonene, a natural cyclic terpene, is an agonistic ligand for adenosine A(2A) receptors 017701
• Limonene, a natural cyclic terpene, is an agonistic ligand for adenosine A(2A) receptors 016776
• Limonene, citrus fruits and rheumatoid arthritis 005660
• Paeoniflorin exerts analgesic and hypnotic effects via adenosine A1 receptors in a mouse neuropathic pain model 019432
• Rheumatoid arthritis and adenosine 005659
• Rheumatoid arthritis and food 005581
• Russet apples, pears, cox's pippin and anti-inflammatories 005902
• Therapeutic benefits of garlic 006174

Wisdom, Inspiration, Divine love & Bliss

• Instenon and hexabendine 005768
• Limonene, a natural cyclic terpene, is an agonistic ligand for adenosine A(2A) receptors 017701

In time

Synaesthesia, Pure or enhanced perception, Inter composer communication, Vision, Dream, Perception recall, Exploring group perception

• Danielou, Alain – On drugs you are possessed by the spirit being of the drug 022582

Other observations

• Dilazep slows the heart down 005767