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Observations placeholder

Adenosine and asthma

Identifier

005301

Type of Spiritual Experience

Background

This paper shows that drugs don't work, you need to go back to the causes, not treat the problem with externally administered adenosine but redress the balance that has occurred in the body's own system.

And maybe cut out the energy drinks, the coffee, the chocolates.....

A description of the experience

Br J Pharmacol. 2008 Oct;155(4):463-74. doi:  .1038/bjp.2008.329. Epub 2008 Sep 1.   Treating lung inflammation with agonists of the adenosine A2A receptor: promises, problems and potential solutions. Trevethick MA, Mantell SJ, Stuart EF, Barnard A, Wright KN, Yeadon M.   Allergy and Respiratory Biology, Pfizer Global R&D, Sandwich, Kent, UK. mike.trevethick@pfizer.com

 Adenosine A(2A) receptor agonists may be important regulators of inflammation. Such conclusions have come from studies demonstrating that,
(i) adenosine A(2A) agonists exhibit anti-inflammatory properties in vitro and in vivo,
(ii) selective A(2A) antagonists enhance inflammation in vivo and,
(iii) knock outs of this receptor aggravate inflammation in a wide variety of in vivo models.

Inflammation is a hallmark of asthma and COPD and adenosine has long been suggested to be involved in disease pathology. Two recent publications, however, suggested that an inhaled adenosine A(2A) receptor agonist (GW328267X) did not affect either the early and late asthmatic response or symptoms associated with allergic rhinitis suggesting that the rationale for treating inflammation with an adenosine A(2A) receptor agonist may be incorrect.

A barrier to fully investigating the role of adenosine A(2A) receptor agonists as anti-inflammatory agents in the lung is the side effect profile due to systemic exposure, even with inhalation. Unless strategies can be evolved to limit the systemic exposure of inhaled adenosine A(2A) receptor agonists, the promise of treating lung inflammation with such agents may never be fully explored.

Using strategies similar to that devised to improve the therapeutic index of inhaled corticosteroids, UK371,104 was identified as a selective agonist of the adenosine A(2A) receptor that has a lung focus of pharmacological activity following delivery to the lung in a pre clinical in vivo model of lung function. Lung-focussed agents such as UK371,104 may be suitable for assessing the anti-inflammatory potential of inhaled adenosine A(2A) receptor agonists.

PMID: 18846036

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Commonsteps

References