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Osteoporosis treatments

Category: Medicines

Type

Involuntary and voluntary

Introduction and description

Osteoporosis can be helped by a number of relatively simple measures, and many of those relate to finding the cause of the problem, follow the link to get more details of the causes of osteoporosis and how it can be helped.

But the current medical practise, being symptom and not cause based, uses a number of pharmaceutical treatments for osteoporosis including

Bisphosphonates  (also called diphosphonates) are the most commonly prescribed drugs used to treat osteoporosis.  Bisphosphonates are also used to both prevent and treat, osteitis deformans ("Paget's disease of bone"), bone metastasis (with or without hypercalcaemia), multiple myeloma, primary hyperparathyroidism, osteogenesis imperfecta, fibrous dysplasia, and other conditions that feature bone fragility.

The theory behind them is based on the fact that bone undergoes constant turnover and is kept in balance (homeostasis) by osteoblasts creating bone and osteoclasts destroying bone. Bisphosphonates' inhibit the digestion of bone by encouraging osteoclasts to undergo apoptosis, or cell death, thereby slowing bone loss'.

Unfortunately this blanket approach to osteoporosis rather ignores its cause.  It is a very limited symptom based approach.

Side-Effects

Oral bisphosphonates can cause a range of side-effects including

  • Stomach disease - upset stomach and inflammation and erosions of the esophagus,  fever and flu-like symptoms
  • ONJ - Bisphosphonates, when administered intravenously for the treatment of cancer, have been associated with osteonecrosis of the jaw (ONJ), with the mandible twice as frequently affected as the maxilla
  • Pain - A number of cases of severe bone, joint, or musculoskeletal pain have been reported, 'prompting labeling changes'
  • Atrial fibrillation - Recent studies have reported bisphosphonate use as a risk factor for atrial fibrillation in women.  ‘The inflammatory response to bisphosphonates or fluctuations in calcium blood levels have been suggested as possible mechanisms’.  One study estimated that 3% of atrial fibrillation cases might have been due to alendronate use.
  • Broken bones - In large studies, women taking bisphosphonates for osteoporosis have had unusual fractures ("bisphosphonate fractures") in the femur (thigh bone) in the of the bone, rather than at the head of the bone, which is the most common site of fracture. ‘There are concerns that long-term bisphosphonate use can result in over-suppression of bone turnover’. It is hypothesized that micro-cracks in the bone are unable to heal and eventually unite and propagate, resulting in atypical fractures. Such fractures tend to heal poorly and often require some form of bone stimulation, for example bone grafting as a secondary procedure.
  • Cancer - A 2010 study suggests that the risk of oesophageal cancer increased with 10 or more prescriptions for oral bisphosphonates and with prescriptions over about a five-year period. In Europe and North America, the incidence of oesophageal cancer at age 60–79 is typically 1 per 1000 population over five years, and this is estimated to increase to about 2 per 1000 with five years' use of oral bisphosphonates.

Taking one example drug - Fosmax, and using the figures from eHealthme, the most common Fosamax side effects are:

  • Femur Fracture (13,708 reports)
  • Fall  (9,950 reports)
  • Aseptic Necrosis  (9,104 reports)
  • Stress And Anxiety  (7,373 reports)
  • High Blood Pressure  (6,786 reports)
  • Depression  (6,638 reports)
  • Joint Pain  (6,233 reports)
  • Osteoarthritis  (6,175 reports)
  • Low Turnover Osteopathy  (5,531 reports)
  • Back Pain  (5,231 reports)

 

Death

Using the Adverse drug reports submitted by doctors to the FDA and SEDA and summarised on the eHealthme website, these are the figures for death - the ultimate spiritual experience.  These figures only apply to the USA where the ADRs are collected ad not to the rest of the world:

Risedronate plus trade names

  • On Sep, 1, 2015: 3,344 people reported to have side effects when taking Risedronate sodium. Among them, 56 people (1.67%) have Death
  • On Aug, 22, 2015: 17,391 people reported to have side effects when taking Actonel. Among them, 216 people (1.24%) have Death
  • On Aug, 24, 2015: 118 people reported to have side effects when taking Atelvia. Among them, 1 people (0.85%) has Death
 

Calcitriol and its trade names -Calcitriol is marketed under various trade names including Rocaltrol, Calcijex, Decostriol, Biowoz and Vectical, Rolsical

  • Calcitriol - On Aug, 10, 2015: 5,720 people reported to have side effects when taking Calcitriol. Among them, 113 people (1.98%) have Death
  • Rocaltrol - On Sep, 1, 2015: 3,469 people reported to have side effects when taking Rocaltrol. Among them, 66 people (1.90%) have Death
  •  Vectical - On Sep, 1, 2015: 58 people reported to have side effects when taking Vectical. Among them, 2 people (3.45%) have Death

 Etidronate and trade names

  • Etidronate - On Sep, 1, 2015: 520 people reported to have side effects when taking Etidronate disodium. Among them, 3 people (0.58%) have Death
  • Didronel - On Aug, 26, 2015: 1,540 people reported to have side effects when taking Didronel. Among them, 18 people (1.17%) have Death

 Teriparatide and trade names

  • Forteo - On Aug, 11, 2015: 56,589 people reported to have side effects when taking Forteo. Among them, 2,017 people (3.56%) have Death

Alendronic acid and trade names

  • Alendronate sodium - On Sep, 1, 2015: 17,590 people reported to have side effects when taking Alendronate sodium. Among them, 170 people (0.97%) have Death
  • On Aug, 27, 2015: 2,395 people reported to have side effects when taking Alendronic acid. Among them, 50 people (2.09%) have Death
  • Fosamax - On Sep, 1, 2015: 69,906 people reported to have side effects when taking Fosamax. Among them, 1,749 people (2.50%) have Death
 

Pamidronic acid and trade names.  In India, it is marketed by Curacell Biotech under the brand name Pamimed

  • Pamidronate disodium - On Sep, 1, 2015: 3,497 people reported to have side effects when taking Pamidronate disodium. Among them, 111 people (3.17%) have Death
  • Aredia - On Aug, 27, 2015: 13,495 people reported to have side effects when taking Aredia. Among them, 834 people (6.18%) have Death. 

 Vitamin D supplements/tablets etc - On Sep, 1, 2015: 2,477 people reported to have side effects when taking Vitamin d. Among them, 3 people (0.12%) have Death

Zoledronic acid and trade names

  •  Zoledronate - On Aug, 3, 2015: 4,452 people reported to have side effects when taking Zoledronic acid. Among them, 210 people (4.72%) have Death
  • Zometa - On Aug, 23, 2015: 38,837 people reported to have side effects when taking Zometa. Among them, 3,125 people (8.05%) have Death
  • Reclast - On Aug, 3, 2015: 8,474 people reported to have side effects when taking Reclast. Among them, 1,108 people (13.08%) have Death

Denosumab and its trade names

  • Prolia - On Aug, 6, 2015: 5,813 people reported to have side effects when taking Prolia. Among them, 155 people (2.67%) have Death
  • Xgeva - On Aug, 14, 2015: 1,418 people reported to have side effects when taking Xgeva. Among them, 55 people (3.88%) have Death

Ibandronic acid and its trade names

  • Ibandronate sodium - On Sep, 1, 2015: 1,226 people reported to have side effects when taking Ibandronate sodium. Among them, 95 people (7.75%) have Death
  • Boniva - On Sep, 1, 2015: 16,175 people reported to have side effects when taking Boniva. Among them, 538 people (3.33%) have Death

Summary total

 

 

Using the Adverse drug reports submitted by doctors to the FDA and SEDA and summarised on the eHealthme website, the total deaths as at mid August 2015 are 

10,695

 These figures only apply to the USA where the ADRs are collected and not to the rest of the world

 

 

How it works

All the spiritual experiences for this pharmaceutical are hallucinations or similar [visons, near death etc], as such we can trace this either to overdose  and poisoning or via the side-effects they produce  - in effect it was the illnesses they caused, that caused the hallucinations.

Both ONJ and fractures cause pain thus this must be a high contributor.

Observations

The total of all the hallucinations caused by these drugs is summarised below - all come from the eHealthme web site.  The link takes you to the up-to-date page on ehealthme for all side -effects:

Pharmaceutical

No of hallucination

Actonel

16

Risedronate sodium [Actonel, Atelvia, and Benet]

6

Calcitriol

35

Etidronate disodium and Didronel

7

Teriparatide (Forteo)

21

Fosamax

73

Pamidronate disodium

2

Aredia

22

Vitamin D supplements

4

Zometa

27

TOTAL

213

 

 

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