Toxic agents causing cerebellar ataxias
Type of Spiritual Experience
A description of the experience
Handb Clin Neurol. 2012;103:201-13. doi: 10.1016/B978-0-444-51892-7.00012-7.
Toxic agents causing cerebellar ataxias.
- 1Unité d'Etude du Mouvement, FNRS Neurologie, ULB Erasme, Brussels, Belgium. firstname.lastname@example.org
The cerebellum is particularly vulnerable to intoxication and poisoning, especially so the cerebellar cortex and Purkinje neurons. In humans, the most common cause of a toxic lesion to the cerebellar circuitry is alcohol related, but the cerebellum is also a main target of
- drug exposure (such as anticonvulsants, antineoplastics, lithium salts, calcineurin inhibitors),
- drug abuse and addiction (such as cocaine, heroin, phencyclidine), and
- environmental toxins (such as mercury, lead, manganese, toluene/benzene derivatives).
Although data for the prevalence and incidence of cerebellar lesions related to intoxication and poisoning are still unknown in many cases, clinicians should keep in mind the list of agents that may cause cerebellar deficits, since toxin-induced cerebellar ataxias are not rare in daily practice. Moreover, the patient's status may require immediate therapies when the intoxication is life-threatening.
2012 Elsevier B.V. All rights reserved.
The source of the experiencePubMed
Concepts, symbols and science items
Activities and commonsteps
Heavy metal poisoning
Inhaling volatiles and gases