Methotrexate and Trexall
Type of Spiritual Experience
Reversible dementia temporally associated with intraventricular therapy with methotrexate in a child with acute myelogenous leukaemia - Pizzo PA Bleyer WA, Poplack DG, Leventhal BG.
During maintenance therapy with intraventricular methotrexate, progressive dementia developed in a child with meningeal leukemia. Cerebrospinal fluid levels of MTX were in the nontoxic range and neurologic evaluation failed to demonstrate anatomic obstruction, infection, or folate depletion. The patient's symptoms gradually resolved when the methotrexate was discontinued, suggesting that methotrexate neurotoxicity may occur in the absence of an elevated CSF concentration of MTX.
Severe neurological damage associated with methotrexate therapy - Kay HE, Knapton PJ, O'Sullivan JP, Wells DG, Harris RF, Innes EM, Stuart J, Schwartz FC, Thompson EN. Lancet. 1971 Sep 4;2(7723):542. PMID: 4105681
A description of the experience
Methotrexate (oral) (meth oh TREX ate) Brand Names: Rheumatrex Dose Pack, Trexall is an immunosuppressant. Methotrexate interferes with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells.
Methotrexate is abbreviated MTX and formerly known as amethopterin, Methotrexate is an antimetabolite and antifolate drug. It is used in the treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid.
The most common adverse effects include: ulcerative stomatitis, low white blood cell count and thus predisposition to infection, nausea, abdominal pain, fatigue, fever, dizziness and rarely pulmonary fibrosis. Central nervous system reactions to methotrexate have been reported – and is serious. Penicillins may decrease the elimination of methotrexate and thus increase the risk of toxicity.
- Autoimmune disease treatment - Methotrexate is also used as a treatment for some autoimmune diseases including: rheumatoid arthritis, psoriasis, psoriatic arthritis, and Crohn's disease. Although methotrexate was originally designed as a chemotherapy drug (in high doses), it is used in low-doses in the treatment of autoimmune diseases. It is frequently used in the treatment of rheumatoid arthritis. For the treatment of rheumatoid arthritis, inhibition of DHFR is not thought to be the main mechanism, but rather the inhibition of enzymes involved in purine metabolism, leading to accumulation of adenosine, or the inhibition of T cell activation
- Pregnancy termination - Finally, Methotrexate is commonly used (generally in combination with misoprostol) to terminate pregnancies during the early stages
On Aug, 13, 2015: 65 people reported to have side effects when taking Methotrexate preservative free. Among them, 1 people (1.54%) has Hallucination
On Jan, 22, 2017 140 people reported to have side effects when taking Methotrexate Lpf. Among them, 1 person (0.71%) has Hallucination
On Jan, 02, 2017 11,813 people reported to have side effects when taking Methotrexate Sodium. Among them, 7 people (0.06%) have Hallucination
On Jan, 03, 2017 11,813 people reported to have side effects when taking Methotrexate Sodium. Among them, 8 people (0.07%) have Hallucination, Auditory
On Jan, 04, 2017 209,150 people reported to have side effects when taking Methotrexate. Among them, 248 people (0.12%) have Hallucinations
Time on Methotrexate when people have Hallucination :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years|
Gender of people who have Hallucination when taking Methotrexate :
Age of people who have Hallucination when taking Methotrexate :
Severity of Hallucination when taking Methotrexate :
How people recovered from Hallucination :
|while on the drug||after off the drug||not yet|
The source of the experienceeHealthme
Concepts, symbols and science items
Activities and commonsteps