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Observations placeholder

Metals and Parkinson's Disease: Mechanisms and Biochemical Processes.

Identifier

029499

Type of Spiritual Experience

None

Background

A description of the experience

Curr Med Chem. 2018;25(19):2198-2214. doi: 10.2174/0929867325666171129124616.
Metals and Parkinson's Disease: Mechanisms and Biochemical Processes.
Bjorklund G1, Stejskal V2, Urbina MA3, Dadar M4, Chirumbolo S5, Mutter J6,7.
 
Abstract
Genetic background accounts for only 5 to 10% of the reported cases of Parkinson's disease (PD), while the remaining cases are of unknown etiology. It is believed that environmental factors may be involved in the causality of a large proportion of PD cases. Several PD genes are activated by xenobiotic exposure, and a link between pesticide exposure and PD has been demonstrated. Many epidemiological studies have shown an association between PD and exposure to metals such as

  • mercury
  • lead
  • manganese
  • copper
  • iron
  • aluminum
  • bismuth
  • thallium and
  • zinc.

This review explores the biological effects, the pathogenetic processes, genetic susceptibilities to metals as well as examining future strategies for PD treatment, such as chelation therapy.

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
KEYWORDS:
Substantia nigra; alpha-synuclein; beta-amyloid; dopamine; glutamate; glutathione; metals; oxidative stress.
PMID:
29189118

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Pesticide

Activities and commonsteps

Commonsteps

References