Benign prostatic hyperplasia drugs

Category: Medicines

Type

Involuntary and voluntary

Introduction and description

Physicians use this class of drugs for the treatment of Benign prostatic hyperplasia, informally known as an enlarged prostate.

The theory is that this class of drugs “may improve the symptoms associated with BPH such as difficulty urinating, getting up during the night to urinate, hesitation at the start of urination, and decreased urinary flow”.

One of the worst and major symptoms of those suffering from prostate problems is that they find it difficult to wee.  They wee in small dribbles and then need to wee again ten minutes later.  Night times can be a wearying time of no sleep, as over and over again the poor chap wakes up from the need to wee, but can only manage a desultory amount.  But the condition is benign.

There are various mechanisms by which this class of drugs is intended to 'work'.

The Alpha-1 adrenoceptor receptor appears to control the smooth muscle of the bladder and the neck of the bladder.  Thus adrenoceptor agonist products  are theoretically intended to work by “blocking the action of adrenaline on smooth muscle of the bladder”.  This class of drugs are thus used to treat ‘benign prostatic hyperplasia’ by theoretically relaxing the muscles in the prostate and bladder neck, making it easier to urinate. 

There are other products.  One drug, for example, is a type II and type III 5α-reductase inhibitor; 5α-reductase, an enzyme, converts testosterone to dihydrotestosterone (DHT).  As it says in their literature "this provides less symptomatic relief than alpha-1 blockers and symptomatic relief is slower in onset (six months or more of treatment may be required to determine the therapeutic results of treatment)." [this is a genuine quote].  They added "If the drug is discontinued, any therapeutic benefits reverse within about 6–8 months".

In theory the only spiritual experience you should get here is the euphoria from being able to wee.  My Dad had prostrate problems.  I know!  But as we shall see this is far from the case.

The principle problem here is that none of these drugs address the cause of the problems.

Side effects

One of the rather startling aspects of this class of drugs is their side effects.  They are there to treat what is an essentially a benign but annoying problem but the side effects are anything but.  If we take a drug like Terazosin as an example and, using the actual Adverse Drug Reports submitted to SEDA and compiled by eHealthme, this is what we find, this table shows the most frequently reported effects

40-49	50-59	60+
Essential Hypertension	Drug Maladministration	Pulmonary Oedema Nos	Diarrhoea	Oedema Peripheral	Syncope
Nausea		Overdose Nos	Drug Ineffective	Anxiety	Fall
Vomiting		Electrocardiogram Qt Prolonged	Abdominal Pain	Nausea	Nausea
		Electrocardiogram Abnormal Nos	Blood Testosterone Decreased	Fall	Dizziness
		Sinus Bradycardia	Anxiety	Diarrhoea	Hypotension
		Muscle Contractions Involuntary	Blood Cholesterol Increased	Pain	Drug Ineffective
		Thrombocytopenia	Abdominal Pain Upper	Pyrexia	Haemoglobin Decreased
		Thinking Abnormal Nec	Vomiting Nos	Anhedonia	Pneumonia
		Tachycardia Nos	Aspartate Aminotransferase Increased	Pruritus	Rhabdomyolysis
		Speech Disorder Nec	Nausea	Cough	Renal Failure Acute

 

This class of drugs has also affected the sexual function in men.

They can cause males to experience retrograde ejaculation. In males, retrograde ejaculation occurs when the fluid to be ejaculated, which would normally exit the body via the urethra, is redirected to the urinary bladder. Normally, the sphincter of the bladder contracts and the ejaculate goes to the urethra, the area of least pressure. In retrograde ejaculation, this sphincter does not function properly.  There are a considerable number of reports relating to complete sexual dysfunction.

If we now look at the figures for the ultimate spiritual experience of all - death - this is what we find.  At one time we were able to include charts from ehealthme, but sadly as explained above we can no longer provide this information only the figures, please note that not all the drugs are listed, only a sample:

Flomax - On Jun, 14, 2015: 20,464 people reported to have side effects when taking Flomax. Among them, 474 people (2.32%) have Death .

Cardura - On Jun, 21, 2015: 14,944 people reported to have side effects when taking Cardura. Among them, 223 people (1.49%) have Death.

Tamsulosin - On Jun, 28, 2015: 7,564 people reported to have side effects when taking Tamsulosin. Among them, 197 people (2.60%) have Death.

Avodart - On Jun, 21, 2015: 8,178 people reported to have side effects when taking Avodart. Among them, 149 people (1.82%) have Death.[plus 22 Dutasteride]

Proscar - On Jun, 28, 2015: 6,959 people reported to have side effects when taking Proscar. Among them, 147 people (2.11%) have Death.  You can add an extra 12 from Propecia which is the same drug.

Doxazosin mesylate - On Jun, 1, 2015: 7,836 people reported to have side effects when taking Doxazosin mesylate. Among them, 127 people (1.62%) have Death.

On Jun, 12, 2015: 8,188 people reported to have side effects when taking Cialis. Among them, 107 people (1.31%) have Death.

Finasteride - On Jun, 28, 2015: 5,412 people reported to have side effects when taking Finasteride. Among them, 91 people (1.68%) have Death [given that this drug is also prescribed for 'male pattern baldness', this might come as a bit of a shock to those who are bald].

Hytrin - On Jun, 28, 2015: 6,115 people reported to have side effects when taking Hytrin. Among them, 85 people (1.39%) have Death.

 

 

It must be something of a shock for these people's families.  They see their grandfather go to the doctor with a benign condition and he comes back in a coffin. 

References and further reading

I have chosen the photos on this page in memory of my Dad, God bless his little cotton socks, who would have loved them. 

A bit special was my Dad.

They are all from Jaroslav Monchak - a Ukrainian professional photographer. 

He is on facebook and has his own site - LINK

 

Observations

The table below provides a summary of the number of hallucinations from the observations . 

The figures come from the eHealthme web site and were correct as at mid 2015.  More details are provided in each observation:

Observation no	Drug Name	No of hallucinations
016917	Alfuzosin  trade names Uroxatral and Xatral	6
016918	Uroxatral	7
016912	Doxazosin mesylate	42
005123	Cardura	53
-	Prazosin	3
016913	Tamsulosin	57
016914	Flomax	173
001134	Terazosin (marketed as Hytrin)	6
001134	Hytrin	26
016915	Finasteride	32
016916	Proscar [another name for Finasteride]	29
-	Propecia [another name for Finasteride]	2
016919	Avodart	28
-	Dutasteride [another name for Avodart]	8
016920	Cialis	8
-	Jalyn	1
016921	Rapaflo	2
	TOTAL	483

 

• Phenoxybenzamine    It was once used for benign prostatic hyperplasia, but stopped being used because it had ‘unpleasant side effects ‘[unspecified].  It was tried as an alpha blocker for hearts but didn’t work.  As a clearly last ditch attempt to find a use for the drug [and you will understand immediately why when I describe it] it is ‘being considered as a male contraceptive’ because it blocks ejaculation without affecting ‘ability to achieve orgasm’. 
•  Prazosin, trade names Minipress, Vasoflex, Pressin and Hypovase, was developed for use to treat high blood pressure.  It doesn’t work.  It too is now used for benign prostatic hyperplasia. 
• Jalyn - is a combination of two previously existing drugs: Tamsulosin Hydrochloride, trade name Flomax, and Dutasteride, trade name Avodart. It contains 0.4 mg of Tamsulosin Hydrochloride and 0.5 mg of Dutasteride

Related observations

Healing observations

• Anti-androgenic action by red clover-derived dietary isoflavones reduces non-malignant prostate enlargement in aromatase knockout (ArKo) mice 017927
• Assessment of clinical usefulness of Eviprostat for benign prostatic hyperplasia--comparison of Eviprostat tablet with a formulation containing two-times more active ingredients 019572
• Bee venom suppresses testosterone-induced benign prostatic hyperplasia by regulating the inflammatory response and apoptosis 016931
• Plant-derived alternative treatments for the aging male: facts and myths 017930
• Research progress of phytoestrogens-like chemical constituents in natural medicines 017886

Hallucination

• Alfuzosin 016917
• Avodart 016919
• Cardura 005123
• Cialis ,Tadafil , Adcirca 016920
• Doxazosin mesylate 016912
• Dutasteride 018932
• Finasteride 016915
• Flomax 016914
• Jalyn 019226
• MPA - Medroxyprogesterone acetate and Provera 017364
• Propecia 019877
• Proscar 016916
• Rapaflo 019993
• Rapaflo , Silodosin 016921
• Tamsulosin 016913
• Terazosin and Hytrin 001134
• Terazosin Hydrochloride 020197
• Uroxatral 016918

In time

Synaesthesia, Pure or enhanced perception, Inter composer communication, Vision, Dream, Perception recall, Exploring group perception

• Danielou, Alain – On drugs you are possessed by the spirit being of the drug 022582