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Benign prostatic hyperplasia drugs

Category: Medicines

Type

Involuntary and voluntary

Introduction and description

 please see the reference section below as to why these photos
were chosen and credits to the photographer

Physicians use this class of drugs for the treatment of Benign prostatic hyperplasia, informally known as an enlarged prostate.

The theory is that this class of drugs “may improve the symptoms associated with BPH such as difficulty urinating, getting up during the night to urinate, hesitation at the start of urination, and decreased urinary flow”.

One of the worst and major symptoms of those suffering from prostate problems is that they find it difficult to wee.  They wee in small dribbles and then need to wee again ten minutes later.  Night times can be a wearying time of no sleep, as over and over again the poor chap wakes up from the need to wee, but can only manage a desultory amount.  But the condition is benign.

There are various mechanisms by which this class of drugs is intended to 'work'.

The Alpha-1 adrenoceptor receptor appears to control the smooth muscle of the bladder and the neck of the bladder.  Thus adrenoceptor agonist products  are theoretically intended to work by “blocking the action of adrenaline on smooth muscle of the bladder”.  This class of drugs are thus used to treat ‘benign prostatic hyperplasia’ by theoretically relaxing the muscles in the prostate and bladder neck, making it easier to urinate. 

 

There are other products.  One drug, for example, is a type II and type III 5α-reductase inhibitor; 5α-reductase, an enzyme, converts testosterone to dihydrotestosterone (DHT).  As it says in their literature "this provides less symptomatic relief than alpha-1 blockers and symptomatic relief is slower in onset (six months or more of treatment may be required to determine the therapeutic results of treatment)." [this is a genuine quote].  They added "If the drug is discontinued, any therapeutic benefits reverse within about 6–8 months".

In theory the only spiritual experience you should get here is the euphoria from being able to wee.  My Dad had prostrate problems.  I know!  But as we shall see this is far from the case.

The principle problem here is that none of these drugs address the cause of the problems.

In June 2016, eHealthme ceased to provide the information on which all the data in this section is based.  On querying my friends in the USA, it would seem that many of the sites that provided similar information, have done the same.  The links we provided to eHealthme also no longer work as this data too has been removed. 

As to why all these sites have removed exceptionally important information, my USA helpers said that more and more people are questioning what they are being given – and demanding to know WHY the CAUSE of their illness has not been investigated.  It appears that there has been a very heartening increase in the numbers of people who want to be healed – have the cause tackled and not the symptoms.  And this is ‘not popular’ with the conventional medical community, who cannot make money from well people.

The statistics collected from eHealthme remain valid for the date they were collected.  As such we have left this section as it is – an historical record.  Please read this section therefore only as an historical record of the figures that were applicable on the date specified.

Side effects

One of the rather startling aspects of this class of drugs is their side effects.  They are there to treat what is an essentially a benign but annoying problem but the side effects are anything but.  If we take a drug like Terazosin as an example and, using the actual Adverse Drug Reports submitted to SEDA and compiled by eHealthme, this is what we find, this table shows the most frequently reported effects

40-49 50-59 60+
Essential Hypertension Drug Maladministration Pulmonary Oedema Nos Diarrhoea Oedema Peripheral Syncope
Nausea   Overdose Nos Drug Ineffective Anxiety Fall
Vomiting   Electrocardiogram Qt Prolonged Abdominal Pain Nausea Nausea
    Electrocardiogram Abnormal Nos Blood Testosterone Decreased Fall Dizziness
    Sinus Bradycardia Anxiety Diarrhoea Hypotension
    Muscle Contractions Involuntary Blood Cholesterol Increased Pain Drug Ineffective
    Thrombocytopenia Abdominal Pain Upper Pyrexia Haemoglobin Decreased
    Thinking Abnormal Nec Vomiting Nos Anhedonia Pneumonia
    Tachycardia Nos Aspartate Aminotransferase Increased Pruritus Rhabdomyolysis
    Speech Disorder Nec Nausea Cough Renal Failure Acute
 

 

This class of drugs has also affected the sexual function in men.

They can cause males to experience retrograde ejaculation. In males, retrograde ejaculation occurs when the fluid to be ejaculated, which would normally exit the body via the urethra, is redirected to the urinary bladder. Normally, the sphincter of the bladder contracts and the ejaculate goes to the urethra, the area of least pressure. In retrograde ejaculation, this sphincter does not function properly.  There are a considerable number of reports relating to complete sexual dysfunction.

If we now look at the figures for the ultimate spiritual experience of all - death - this is what we find.  At one time we were able to include charts from ehealthme, but sadly as explained above we can no longer provide this information only the figures, please note that not all the drugs are listed, only a sample:

Flomax - On Jun, 14, 2015: 20,464 people reported to have side effects when taking Flomax. Among them, 474 people (2.32%) have Death .

Trend of Death  in Flomax reports

Cardura - On Jun, 21, 2015: 14,944 people reported to have side effects when taking Cardura. Among them, 223 people (1.49%) have Death.

Trend of Death in Cardura reports

Tamsulosin - On Jun, 28, 2015: 7,564 people reported to have side effects when taking Tamsulosin. Among them, 197 people (2.60%) have Death.

Trend of Death in Tamsulosin reports

Avodart - On Jun, 21, 2015: 8,178 people reported to have side effects when taking Avodart. Among them, 149 people (1.82%) have Death.[plus 22 Dutasteride]

Trend of Death in Avodart reports

Proscar - On Jun, 28, 2015: 6,959 people reported to have side effects when taking Proscar. Among them, 147 people (2.11%) have Death.  You can add an extra 12 from Propecia which is the same drug.

Trend of Death in Proscar reports

Doxazosin mesylate - On Jun, 1, 2015: 7,836 people reported to have side effects when taking Doxazosin mesylate. Among them, 127 people (1.62%) have Death.

Trend of Death in Doxazosin mesylate reports

On Jun, 12, 2015: 8,188 people reported to have side effects when taking Cialis. Among them, 107 people (1.31%) have Death.

Trend of Death in Cialis reports

Finasteride - On Jun, 28, 2015: 5,412 people reported to have side effects when taking Finasteride. Among them, 91 people (1.68%) have Death [given that this drug is also prescribed for 'male pattern baldness', this might come as a bit of a shock to those who are bald].

Trend of Death in Finasteride reports

Hytrin - On Jun, 28, 2015: 6,115 people reported to have side effects when taking Hytrin. Among them, 85 people (1.39%) have Death.

Trend of Death in Hytrin reports 

 

It must be something of a shock for these people's families.  They see their grandfather go to the doctor with a benign condition and he comes back in a coffin. 

References and further reading

 

I have chosen the photos on this page in memory of my Dad, God bless his little cotton socks, who would have loved them. 

A bit special was my Dad.

They are all from Jaroslav Monchak - a Ukrainian professional photographer. 

He is on facebook and has his own site - LINK

 

Observations

The table below provides a summary of the number of hallucinations from the observations . 

The figures come from the eHealthme web site and were correct as at mid 2015.  More details are provided in each observation:

Observation no

Drug Name

No of hallucinations

 016917

Alfuzosin  trade names Uroxatral and Xatral

6

 016918

Uroxatral

 7

016912

Doxazosin mesylate

42

005123

Cardura

53

 -

 Prazosin

 3

 016913

Tamsulosin

 57
 016914

Flomax

173
 001134 Terazosin (marketed as Hytrin)  6
 001134  Hytrin  26
 016915  Finasteride  32
 016916  Proscar [another name for Finasteride]  29
 -  Propecia [another name for Finasteride]  2
 016919  Avodart  28
 -  Dutasteride [another name for Avodart]  8
 016920  Cialis  8
- Jalyn 1
016921  Rapaflo  2
   TOTAL  483

 

  • Phenoxybenzamine    It was once used for benign prostatic hyperplasia, but stopped being used because it had ‘unpleasant side effects ‘[unspecified].  It was tried as an alpha blocker for hearts but didn’t work.  As a clearly last ditch attempt to find a use for the drug [and you will understand immediately why when I describe it] it is ‘being considered as a male contraceptive’ because it blocks ejaculation without affecting ‘ability to achieve orgasm’. 
  •  Prazosin, trade names Minipress, Vasoflex, Pressin and Hypovase, was developed for use to treat high blood pressure.  It doesn’t work.  It too is now used for benign prostatic hyperplasia. 
  • Jalyn - is a combination of two previously existing drugs: Tamsulosin Hydrochloride, trade name Flomax, and Dutasteride, trade name Avodart. It contains 0.4 mg of Tamsulosin Hydrochloride and 0.5 mg of Dutasteride

Related observations