The effect of titanium dioxide nanoparticles on neuroinflammation response in rat brain
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There was no mention of hallucinations in the paper, but the category psychosis and behavioural effects led us to conclude hallucinations were possible
A description of the experience
Environ Sci Pollut Res Int. 2016 Jul 21. [Epub ahead of print] The effect of titanium dioxide nanoparticles on neuroinflammation response in rat brain. Grissa I1, Guezguez S2, Ezzi L2, Chakroun S2, Sallem A2,3, Kerkeni E2, Elghoul J4,5, El Mir L4,5, Mehdi M2,3, Cheikh HB2, Haouas Z2.
1Laboratory of Histology and Cytogenetics (UR12ES10), Faculty of Medicine, 5019, Monastir, Tunisia. firstname.lastname@example.org.
2Laboratory of Histology and Cytogenetics (UR12ES10), Faculty of Medicine, 5019, Monastir, Tunisia.
3Laboratory of Physics of Materials and Nanomaterials Applied at Environment (LaPhyMNE), Faculty of Sciences in Gabes, Gabes University, 6072, Gabes, Tunisia.
4Department of Physics, College of Sciences, Al Imam Mohammad Ibn Saud Islamic University (IMISU), Riyadh, 11623, Saudi Arabia.
5Cytogenetic and Reproductive Biology Department, Fattouma Bourguiba Teaching Hospital, Monastir, Tunisia.
Titanium dioxide nanoparticles (TiO2 NPs) are widely used for their whiteness and opacity in several applications such as food colorants, drug additives, biomedical ceramic, and implanted biomaterials.
Research on the neurobiological response to orally administered TiO2 NPs is still limited. In our study, we investigate the effects of anatase TiO2 NPs on the brain of Wistar rats after oral intake.
After daily intragastric administration of anatase TiO2 NPs (5-10 nm) at 0, 50, 100, and 200 mg/kg body weight (BW) for 60 days, the coefficient of the brain, acethylcholinesterase (AChE) activities, the level of interleukin 6 (IL-6), and the expression of glial fibrillary acidic protein (GFAP) were assessed to quantify the brain damage.
The results showed that high-dose anatase TiO2 NPs could induce a downregulated level of AChE activities and showed an increase in plasmatic IL-6 level as compared to the control group accompanied by a dose-dependent decrease inter-doses, associated to an increase in the cerebral IL-6 level as a response to a local inflammation in brain.
Furthermore, we observed elevated levels of immunoreactivity to GFAP in rat cerebral cortex.
We concluded that oral intake of anatase TiO2 NPs can induce neuroinflammation and could be neurotoxic and hazardous to health.
Astrocytes; Brain; Neurochemicals; Neuroinflammation; Rats; Titanium dioxide nanoparticles