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Modulatory role of Acacia honey from north-west Nigeria on sodium arsenite-induced clastogenicity and oxidative stress in male Wistar rats

Identifier

020539

Type of Spiritual Experience

Background

A clastogen in biology is a mutagenic agent giving rise to or inducing disruption or breakages of chromosomes, leading to sections of the chromosome being deleted, added, or rearranged.

This process is a form of mutagenesis, and can lead to carcinogenesis, as cells that are not killed by the clastogenic effect may become cancerous. Known clastogens include acridine yellow, benzene, ethylene oxide, arsenic, phosphine and mimosine.

Exposure to clastogens increases frequency of abnormal germ cells in paternal males, contributing to developmental effects in the fetus upon fertilization.

A description of the experience

Nat Prod Res. 2015;29(4):321-6. doi: 10.1080/14786419.2014.940945. Epub 2014 Aug 8.

Modulatory role of Acacia honey from north-west Nigeria on sodium arsenite-induced clastogenicity and oxidative stress in male Wistar rats.

Muhammad A1, Odunola OA, Gbadegesin MA, Adegoke AM, Olugbami JO, Uche NS.

Author information

  • 1a Cancer Research and Molecular Biology Laboratories, Department of Biochemistry , University of Ibadan , Ibadan , Oyo , Nigeria.

Abstract

Effect of Acacia honey from north-west Nigeria on sodium arsenite-induced oxidative damage and clastogenicity in male Wistar rats was investigated. Animals were divided into four groups and were treated daily via oral gavage for one week before they were sacrificed. Brain, liver and blood serum were collected for antioxidant and protein assays. Clastogenicity, in vitro antioxidant activity, vitamins and minerals were also evaluated. From the results, co-administration of Acacia honey with sodium arsenite on the animals increased (P < 0.05) glutathione peroxidase, superoxide dismutase and catalase activities with concomitant decrease in malondialdehyde levels and anti-clastogenic effects relative to the group treated with sodium arsenite only. The honey possesses reducing power, high hydrogen peroxide scavenging activity, good amount of vitamins (A, C and E), flavonoids (5.08 ± 0.92 mg QE/100 g) and phenolics (5.40 ± 0.69 mg GAE/100 g). The minerals present include zinc, iron, sodium, magnesium, potassium and calcium. In conclusion, Acacia honey from Nigeria may mitigate oxidative stress and clastogenicity.

KEYWORDS:

Acacia honey; Nigeria; clastogen; oxidative damage; sodium arsenite

PMID:

25105348

The source of the experience

PubMed

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References