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Histidine, histamine and its multiple healing roles



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Histamine is made from histidine

Oncology is a branch of medicine that deals with the study, treatment, diagnosis and prevention of cancer.

Since histamine and histadine prevent and fight against these problems, it follows that anti-histamines can cause them

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Int Arch Allergy Immunol. 2012;158 Suppl 1:2-6. doi: 10.1159/000337735. Epub 2012 May 15.

Pathophysiologic role of histamine: evidence clarified by histidine decarboxylase gene knockout mice.

Ohtsu H1.

  • 1Department of Applied Quantum Medical Engineering, School of Engineering, Tohoku University, Sendai, Japan. hiroshi.ohtsu@qse.tohoku.ac.jp


The role of histamine in various murine disease models has been clarified using histidine decarboxylase gene knockout mice.

The mice were generated using conventional gene-targeting methods. Studies, including ours, using knockout mice have shown that the activity of histamine is not limited to allergic, peptic and neurologic functions as in the old paradigm, but extends to other processes related to

  • wound healing,
  • circulatory disease,
  • immunology,
  • oncology and
  • infectious disease.

The recent observation of the activity of newly cloned histamine receptors and a pathophysiologic effect of histamine has dramatically expanded our understanding of the scope of histamine function.

Copyright © 2012 S. Karger AG, Basel.



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