Overload

Anaemia drugs

Category: Medicines

Type

Involuntary and voluntary

Introduction and description

 

Anaemia is a decrease in number of red blood cells (RBCs) or less than the normal quantity of hemoglobin in the blood. However, it can include decreased oxygen-binding ability of each hemoglobin molecule due to deformity or lack in numerical development as in some other types of hemoglobin deficiency.

Anaemia drugs aim to treat anaemia

Anaemia as a symptom not an illness

Whenever the body detects any form of unwanted invader, the Immune system is brought into action.  Our immune system is a system of biological structures and processes that protects against disease by identifying and killing pathogens and tumour cells. It detects a wide variety of agents, from viruses to bacteria, to parasitic worms.

Our defence system is to be found not in our red blood cells but our white blood cells.  Leukocytes are key to our defense – storm troopers. They are not the only defense, but they are a major part of our defences.  In a sense instead of looking at anaemia as a disease, we should perhaps be looking at it as a symptom - an increase in white cells is a sign our body is fighting an intruder.

Thus instead of fighting anaemia we should turn our attention to the cause of the anaemia - virus, heavy metal, bacteria, nutritional imbalance, parasite, toxin, fungi, pharmaceuticals including vaccines and radiation.

Drugs and side effects

 

The first line of treatment from many of the old school doctors when presented with a patient looking weary tired, a bit thin and with the pale skin of the person who is 'anaemic' is to dose them up with iron tablets.  There are still a fair number of medical staff who dose children on iron irrespective of whether they are anaemic or not, on the grounds it 'can do them no harm'. 

Iron supplements

Iron supplements can produce iron overload and add more problems than they ever solve.  Iron as part of a balanced diet and deriving from food, comes in moderation.  But in supplements is overload.  Old people, for example, given iron supplements in the mistaken belief it will help their anaemia can end up with dementia, Alzheimers, plus many more brain related problems:. 

The redox nature of iron renders the metal toxic in excess and consequently all biological organisms carefully control iron levels. …... Elevated iron levels can occur systemically or locally, each giving rise to specific symptoms. Systemic iron overload can result from hyperabsorption of iron or regular blood transfusion. The symptoms of many forms of neurodegeneration are associated with elevated levels of iron in certain regions of the brain PMID: 24470094

They may also end up with cancer ................

 

Many studies indicate that animals and humans burdened with excess iron are at increased risk of neoplasia at various sites. This review focuses on inquiries that involve iron and colorectal cancer. Relevant studies reported in the past decade are briefly described and evaluated. The studies in animal models and in relatively large groups of humans point to a positive association of excessive iron with colorectal oncogenesis. PMID: 8043985

There are links with iron, IBS and various forms of bacterial infection:

Reflecting this link between iron bioavailability and bacterial growth, the taking of oral iron supplements causes a relative over abundance of iron that can alter the types of bacteria that are present within the gut. There have been concerns regarding parenteral iron being administered whilst infection is present, ...Moderate iron deficiency, in contrast, can provide protection against acute infection, especially against organisms that reside within hepatocytes and macrophages such as Malaria and TB

 

Feraheme - On Sep, 9, 2015: 428 people reported to have side effects when taking Feraheme. Among them, 3 people (0.70%) have Death

Ferrlecit - On Sep, 6, 2015: 1,216 people reported to have side effects when taking Ferrlecit. Among them, 41 people (3.37%) have Death

Ferrous fumarate - On Aug, 23, 2015: 301 people reported to have side effects when taking Ferrous fumarate. Among them, 5 people (1.66%) have Death.

Iron dextran - On Sep, 9, 2015: 621 people reported to have side effects when taking Iron dextran. Among them, 3 people (0.48%) have Death

Venofer - On Sep, 9, 2015: 2,238 people reported to have side effects when taking Venofer. Among them, 55 people (2.46%) have Death

Eprex

 

Other than the iron supplements there is only one other  pharmaceutical in this category - Erythropoietin sold as a drug under the tradname Eprex. Erythropoietin is classified as an Antianaemic agent, Hematopoietic growth factor drug, and a Glycoprotein hormone which stimulates red blood cell formation in higher organisms.

Given what has just been said about anaemia, this may not be such a wise move.

If we now turn to the eHealthme web site and look at the results from their analysis of the Adverse Drug Reports submitted by doctors to the FDA and SEDA, we find that the most common Eprex side effects are:

  • Red Cell Aplasia  (1,370 reports)
  • Drug Ineffective  (1,091 reports)
  • Anti-erythropoietin Antibody Positive  (626 reports)
  • Aplasia Pure Red Cell  (283 reports)
  • Haemoglobin Decreased  (249 reports)
  • Anaemia (231 reports)
  • Drug Effect Decreased  (229 reports)
  • Bone Marrow Depression (193 reports)
  • Therapeutic Response Decreased  (137 reports)
  • Thrombocytopenia (133 reports)

 Most common side effects by age  :

0-1

2-9

10-19

20-29

30-39

40-49

50-59

60+

Sick Sinus Syndrome

Red Cell Aplasia

Drug Ineffective

Red Cell Aplasia

Red Cell Aplasia

Red Cell Aplasia

Red Cell Aplasia

Red Cell Aplasia

Cyanosis Nos

Mydriasis

Red Cell Aplasia

Drug Ineffective

Drug Ineffective

Drug Ineffective

Drug Ineffective

Drug Ineffective

Erythema Nec

Hepatic Failure

Anti-erythropoietin Antibody Positive

Haemoglobin Decreased

Anti-erythropoietin Antibody Positive

Anti-erythropoietin Antibody Positive

Anti-erythropoietin Antibody Positive

Anti-erythropoietin Antibody Positive

Torsade De Pointes

Papilloedema

Pancytopenia

Anti-erythropoietin Antibody Positive

Haemoglobin Decreased

Bone Marrow Depression Nos

Aplasia Pure Red Cell

Aplasia Pure Red Cell

White Blood Cell Count Decreased

Pupillary Reflex Impaired

Aplasia Pure Red Cell

Pericarditis Nos

Aplasia Pure Red Cell

Anaemia

Haemoglobin Decreased

Haemoglobin Decreased

Anaphylactic Reaction

Hypocalcaemia

Campylobacter Gastroenteritis

Fatigue

Renal Transplant

Neutropenia

Drug Effect Decreased

Drug Effect Decreased

Peripheral Ischaemia Nos

Death

Anaemia Nos

Nausea

Bone Marrow Depression Nos

Thrombocytopenia

Anaemia

Bone Marrow Depression Nos

Oedema Upper Limb

Serum Ferritin Increased

Bone Marrow Depression Nos

Arthralgia

Drug Effect Decreased

Aplasia Pure Red Cell

Pyrexia

Asthenia

Cough

Blindness Nec

Condition Aggravated

Sleep Disorder Nos

Laboratory Test Abnormal Nos

Drug Effect Decreased

Therapeutic Response Decreased

Thrombocytopenia

Dyspnoea Nos

Atrophy Nos

Viral Infection Nos

Vomiting Nos

Pyrexia

Anaemia Nos

Thrombocytopenia

Therapeutic Response Decreased

Again, the figures from eHealthme - 

On Aug, 29, 2015: 3,851 people reported to have side effects when taking Eprex. Among them, 73 people (1.90%) have Death.

Trend of Death in Eprex reports

Time on Eprex when people have Death:

  < 1 month 1 - 6 months 6 - 12 months 1 - 2 years 2 - 5 years 5 - 10 years 10+ years
Death 53.57% 25.00% 17.86% 3.57% 0.00% 0.00% 0.00%

Gender of people who have Death when taking Eprex:

  Female Male
Death 28.21% 71.79%

Age of people who have Death when taking Eprex:

  0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Death 0.00% 4.17% 0.00% 0.00% 1.39% 2.78% 23.61% 68.06%

How it works

Poisoning

Observations

There are very few hallucinations caused by iron supplements, but the table below has been added for completeness.  The figures come from eHealthme .  The link takes you to eHealthme and shows all the side effects:

Drug

No of hallucinations

Ezfe generic name: iron polysaccharide class: iron products

0

Feosol Original  generic name: ferrous sulfate class: iron products

0

Fer-In-Sol generic name: ferrous sulfate class: iron products

0

Feraheme generic name: ferumoxytol class: iron products

0

Fergon generic name: ferrous gluconate class: iron products

0

FeroSul generic name: ferrous sulfate class: iron products

0

Ferrex-150 generic name: iron polysaccharide class: iron products

0

Ferrlecit  generic namesodium ferric gluconate

1

Ferrocite generic name: ferrous fumarate class: iron products

2

Hematinic with Folic Acid generic name: ferrous fumarate/folic acid class: iron products, vitamin and mineral combinations

0

Hemocyte generic name: ferrous fumarate class: iron products

0

Infed generic name: iron dextran class: iron products

6

Niferex generic name: iron polysaccharide class: iron products

0

Polysaccharide Iron generic name: iron polysaccharide class: iron products

0

Proferrin-ES generic name: heme iron polypeptide class: iron products

0

Slow Fe generic name: ferrous sulfate class: iron products

0

Slow Release Iron generic name: ferrous sulfate class: iron products

0

Tandem generic name: ferrous fumarate/iron polysaccharide class: iron products

2

Venofer generic name: iron sucrose class: iron products

14

TOTAL

25

 

 

 

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