Anaemia drugs

Category: Medicines

Type

Involuntary and voluntary

Introduction and description

Anaemia is a decrease in number of red blood cells (RBCs) or less than the normal quantity of hemoglobin in the blood. However, it can include decreased oxygen-binding ability of each hemoglobin molecule due to deformity or lack in numerical development as in some other types of hemoglobin deficiency.

Anaemia drugs aim to treat anaemia. 

Anaemia as a symptom not an illness

Whenever the body detects any form of unwanted invader, the Immune system is brought into action.  Our immune system is a system of biological structures and processes that protects against disease by identifying and killing pathogens and tumour cells. It detects a wide variety of agents, from viruses to bacteria, to parasitic worms.

Our defence system is to be found not in our red blood cells but our white blood cells.  Leukocytes are key to our defense – storm troopers. They are not the only defense, but they are a major part of our defences.  In a sense instead of looking at anaemia as a disease, we should perhaps be looking at it as a symptom - an increase in white cells is a sign our body is fighting an intruder.

Thus instead of fighting anaemia we should turn our attention to the cause of the anaemia - virus, heavy metal, bacteria, nutritional imbalance, parasite, toxin, fungi, pharmaceuticals including vaccines and radiation.

Drugs and side effects

The first line of treatment from many of the old school doctors when presented with a patient looking weary tired, a bit thin and with the pale skin of the person who is 'anaemic' is to dose them up with iron tablets.  There are still a fair number of medical staff who dose children on iron irrespective of whether they are anaemic or not, on the grounds it 'can do them no harm'. 

Iron supplements

Iron supplements can produce iron overload and add more problems than they ever solve.  Iron as part of a balanced diet and deriving from food, comes in moderation.  But in supplements is overload.  Old people, for example, given iron supplements in the mistaken belief it will help their anaemia can end up with dementia, Alzheimers, plus many more brain related problems:. 

They may also end up with cancer ................

There are links with iron, IBS and various forms of bacterial infection:

Feraheme - On Sep, 9, 2015: 428 people reported to have side effects when taking Feraheme. Among them, 3 people (0.70%) have Death

Ferrlecit - On Sep, 6, 2015: 1,216 people reported to have side effects when taking Ferrlecit. Among them, 41 people (3.37%) have Death

Ferrous fumarate - On Aug, 23, 2015: 301 people reported to have side effects when taking Ferrous fumarate. Among them, 5 people (1.66%) have Death.

Iron dextran - On Sep, 9, 2015: 621 people reported to have side effects when taking Iron dextran. Among them, 3 people (0.48%) have Death

Venofer - On Sep, 9, 2015: 2,238 people reported to have side effects when taking Venofer. Among them, 55 people (2.46%) have Death

Eprex

Other than the iron supplements there is only one other  pharmaceutical in this category - Erythropoietin sold as a drug under the tradname Eprex. Erythropoietin is classified as an Antianaemic agent, Hematopoietic growth factor drug, and a Glycoprotein hormone which stimulates red blood cell formation in higher organisms.

Given what has just been said about anaemia, this may not be such a wise move.

If we now turn to the eHealthme web site and look at the results from their analysis of the Adverse Drug Reports submitted by doctors to the FDA and SEDA, we find that the most common Eprex side effects are:

• Red Cell Aplasia  (1,370 reports)
• Drug Ineffective  (1,091 reports)
• Anti-erythropoietin Antibody Positive  (626 reports)
• Aplasia Pure Red Cell  (283 reports)
• Haemoglobin Decreased  (249 reports)
• Anaemia (231 reports)
• Drug Effect Decreased  (229 reports)
• Bone Marrow Depression (193 reports)
• Therapeutic Response Decreased  (137 reports)
• Thrombocytopenia (133 reports)

 Most common side effects by age  :

0-1	2-9	10-19	20-29	30-39	40-49	50-59	60+
Sick Sinus Syndrome	Red Cell Aplasia	Drug Ineffective	Red Cell Aplasia	Red Cell Aplasia	Red Cell Aplasia	Red Cell Aplasia	Red Cell Aplasia
Cyanosis Nos	Mydriasis	Red Cell Aplasia	Drug Ineffective	Drug Ineffective	Drug Ineffective	Drug Ineffective	Drug Ineffective
Erythema Nec	Hepatic Failure	Anti-erythropoietin Antibody Positive	Haemoglobin Decreased	Anti-erythropoietin Antibody Positive	Anti-erythropoietin Antibody Positive	Anti-erythropoietin Antibody Positive	Anti-erythropoietin Antibody Positive
Torsade De Pointes	Papilloedema	Pancytopenia	Anti-erythropoietin Antibody Positive	Haemoglobin Decreased	Bone Marrow Depression Nos	Aplasia Pure Red Cell	Aplasia Pure Red Cell
White Blood Cell Count Decreased	Pupillary Reflex Impaired	Aplasia Pure Red Cell	Pericarditis Nos	Aplasia Pure Red Cell	Anaemia	Haemoglobin Decreased	Haemoglobin Decreased
Anaphylactic Reaction	Hypocalcaemia	Campylobacter Gastroenteritis	Fatigue	Renal Transplant	Neutropenia	Drug Effect Decreased	Drug Effect Decreased
Peripheral Ischaemia Nos	Death	Anaemia Nos	Nausea	Bone Marrow Depression Nos	Thrombocytopenia	Anaemia	Bone Marrow Depression Nos
Oedema Upper Limb	Serum Ferritin Increased	Bone Marrow Depression Nos	Arthralgia	Drug Effect Decreased	Aplasia Pure Red Cell	Pyrexia	Asthenia
Cough	Blindness Nec	Condition Aggravated	Sleep Disorder Nos	Laboratory Test Abnormal Nos	Drug Effect Decreased	Therapeutic Response Decreased	Thrombocytopenia
Dyspnoea Nos	Atrophy Nos	Viral Infection Nos	Vomiting Nos	Pyrexia	Anaemia Nos	Thrombocytopenia	Therapeutic Response Decreased

Again, the figures from eHealthme - 

On Aug, 29, 2015: 3,851 people reported to have side effects when taking Eprex. Among them, 73 people (1.90%) have Death.

Time on Eprex when people have Death:

	< 1 month	1 - 6 months	6 - 12 months	1 - 2 years	2 - 5 years	5 - 10 years	10+ years
Death	53.57%	25.00%	17.86%	3.57%	0.00%	0.00%	0.00%

Gender of people who have Death when taking Eprex:

	Female	Male
Death	28.21%	71.79%

Age of people who have Death when taking Eprex:

	0-1	2-9	10-19	20-29	30-39	40-49	50-59	60+
Death	0.00%	4.17%	0.00%	0.00%	1.39%	2.78%	23.61%	68.06%

How it works

Poisoning

Observations

There are very few hallucinations caused by iron supplements, but the table below has been added for completeness.  The figures come from eHealthme .  The link takes you to eHealthme and shows all the side effects:

Drug	No of hallucinations
Ezfe generic name: iron polysaccharide class: iron products	0
Feosol Original  generic name: ferrous sulfate class: iron products	0
Fer-In-Sol generic name: ferrous sulfate class: iron products	0
Feraheme generic name: ferumoxytol class: iron products	0
Fergon generic name: ferrous gluconate class: iron products	0
FeroSul generic name: ferrous sulfate class: iron products	0
Ferrex-150 generic name: iron polysaccharide class: iron products	0
Ferrlecit  generic namesodium ferric gluconate	1
Ferrocite generic name: ferrous fumarate class: iron products	2
Hematinic with Folic Acid generic name: ferrous fumarate/folic acid class: iron products, vitamin and mineral combinations	0
Hemocyte generic name: ferrous fumarate class: iron products	0
Infed generic name: iron dextran class: iron products	6
Niferex generic name: iron polysaccharide class: iron products	0
Polysaccharide Iron generic name: iron polysaccharide class: iron products	0
Proferrin-ES generic name: heme iron polypeptide class: iron products	0
Slow Fe generic name: ferrous sulfate class: iron products	0
Slow Release Iron generic name: ferrous sulfate class: iron products	0
Tandem generic name: ferrous fumarate/iron polysaccharide class: iron products	2
Venofer generic name: iron sucrose class: iron products	14
TOTAL	25

 

 

 

Related observations

Hallucination

• Aranesp 018007
• Dacogen 018840
• Erythropoietin hallucinations 005493
• Promacta 019871

Out of time

Near death, Out of time, Out of body, Rebirth

• Dr Robert Crookall - More Astral projections – Mrs B. Titterton, of St Ives has a number of OBEs 023699

In time

Synaesthesia, Pure or enhanced perception, Inter composer communication, Vision, Dream, Perception recall, Exploring group perception

• Danielou, Alain – On drugs you are possessed by the spirit being of the drug 022582