Observations placeholder

The neuroprotective effects of purslane (Portulaca oleracea) on rotenone-induced biochemical changes and apoptosis in brain of rat

Identifier

018908

Type of Spiritual Experience

Background

Rotenone is an odorless, colorless, crystalline ketonic chemical compound used as a broad-spectrum insecticide, piscicide, and pesticide.

A description of the experience

CNS Neurol Disord Drug Targets. 2013 Sep;12(6):830-41.

The neuroprotective effects of purslane (Portulaca oleracea) on rotenone-induced biochemical changes and apoptosis in brain of rat.

Abdel Moneim AE1.

  • 1Department of Zoology and Entomology, Faculty of Science, Helwan University, 11795 Helwan, Cairo, Egypt. aest1977@helwan.edu.eg.

Abstract

Purslane (Portulaca oleraceae L.), a member of the Portulacaceae family, is widespread as a weed and has been ranked as the eighth most common plant in the world.

In order to evaluate purslane herbal aqueous juice as a neuroprotective agent, the antioxidant activity of purslane juice was assessed in vitro and the neuroprotective effects of purslane (1.5 mL/Kg bwt) on rotenone (12 mg/Kg bwt for 12 days) induced biochemical changes and apoptosis in striatum of rats were also examined.

The repeated administration of rotenone produced dramatic increases in intercellular content of calcium, dopamine metabolites and apoptosis in the striatum.

In addition, rotenone administration caused significant decrease in complex I activity.

These biochemical changes and apoptosis inductions were effectively counteracted by administration of purslane.

Overall, the present study demonstrated the neuroprotective role of purslane in the striatum and proposes its prophylactic potential against developing brain damage and Parkinson's disease induction followed by rotenone administration, and that purslane may be considered as a potential neuroprotective agent against environmental factors affecting the function of the dopaminergic system.

PMID:

23844694

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Activities

Overloads

Toxins

Suppressions

Brain damage
Parkinsons disease
Purslane

Commonsteps

References