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Sulfasalazine (SSZ), sold under the trade name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease. It is often considered as a first line treatment in rheumatoid arthritis. It is taken by mouth.

Significant side effects occur in about 25% of people. Commonly these include loss of appetite, nausea, headache, and rash. Severe side effects include bone marrow suppression, liver problems, and kidney problems. It should not be used in people allergic to aspirin or sulfonamide. Use during pregnancy appears to be safe for the baby. Sulfasalazine is in the disease-modifying antirheumatic drugs (DMARDs) family of medications. It is unclear exactly how it works but is broken down into sulfapyridine and 5-aminosalicylic acid [sic].

Most common Sulfasalazine side effects from eHealthme

• Drug ineffective - (1,355 reports)
• Joint pain - (1,059 reports)
• Nausea - (950 reports)
• Fever - (916 reports)
• Rheumatoid arthritis - (842 reports)
• Pain - (833 reports)
• Rashes - (816 reports)
• Fatigue - (796 reports)
• Headache - (793 reports)
• Injection site pain - (723 reports)

On Feb, 06, 2017  17,569 people reported to have side effects when taking Sulfasalazine.
Among them, 164 people (0.93%) have Death

On Feb, 13, 2017  17,569 people reported to have side effects when taking Sulfasalazine.  Among them, 25 people (0.14%) have Hallucination

On Jan, 17, 2017  17,569 people reported to have side effects when taking Sulfasalazine.  Among them, 17 people (0.1%) have Hallucination, Auditory

On Feb, 14, 2017  17,569 people reported to have side effects when taking Sulfasalazine.  Among them, 2 people (0.01%) have Hallucination, Tactile