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Silver fir (Abies alba) trunk extract protects guinea pig arteries from impaired functional responses and morphology due to an atherogenic diet

Identifier

020489

Type of Spiritual Experience

Background

A description of the experience

Silver fir (Abies alba) trunk extract protects guinea pig arteries from impaired functional responses and morphology due to an atherogenic diet

Phytomedicine

Volume 22, Issue 9, 15 August 2015, Pages 856–861

  • Gorazd Drevenšeka, c,
  • Mojca Lundera,
  • Eva Tavčar Benkovićb, , ,
  • Ana Mikeljb,
  • Borut Štrukeljb,
  • Samo Kreftb
  • a University of Ljubljana, Faculty of Medicine, Slovenia
  • b University of Ljubljana, Faculty of Pharmacy, Slovenia
  • c University of Primorska, Faculty of Mathematics, Natural Sciences and Information Technologies, Glagoljaška 8, SI-6000 Koper, Slovenia

Received 5 March 2015, Revised 27 May 2015, Accepted 11 June 2015, Available online 25 June 2015

Abstract

Background

Diet, rich in plant polyphenols prevents atherogenesis that manifests as reduced vascular relaxation and formation of plaques.

Hypothesis

Atherosclerosis could be reduced by the intake of silver fir (Abies alba) extract (SFTE), rich in polyphenols.

Study design

Chronic, in vivo treatment animal study.

Methods

Guinea pigs (Cavia porcellus) were fed for 8 weeks with one of the following three diets: atherogenic, basic or atherogenic + SFTE. After isolation, we measured the relaxation and contractile responses of the thoracic aorta. Additionally, we measured the area of fatty plaques on the aortic walls.

Results

Compared to the basic diet, the atherogenic diet decreased the ability of the aorta to relax by 63% (p < 0.001). The addition of SFTE to the atherogenic diet improved the aorta relaxation response compared to that of the atherogenic diet without SFTE (the decrease relative to the basic diet was 26%, p < 0.001). The aorta contractility did not differ between the groups. The SFTE group generated significantly fewer atherosclerotic plaques than did the atherogenic group. The areas of atherosclerotic plaques were 7.4, 0.3 and 1.6% in the aortas of guinea pigs receiving atherogenic, basic or atherogenic + SFTE diets, respectively.

Conclusions

In a guinea pig model, prolonged treatment with antioxidative polyphenol-rich SFTE prevents aortic functional and morphological changes caused by an atherogenic diet.

 

The source of the experience

PubMed

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