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Romiplostim (rINN, USAN) is a fusion protein analog of thrombopoietin, a hormone that regulates platelet production.

Romiplostim is a man-made form of a protein that increases production of platelets (blood-clotting cells) in your body.

Romiplostim is used to prevent bleeding episodes in people with chronic immune thrombocytopenic purpura (ITP), a bleeding condition caused by a lack of platelets in the blood.

Romiplostim is usually given after other medications have been tried without successful treatment of symptoms.

Romiplostim is not a cure for ITP

Side-effects

Romiplostim's effect is to stimulate the patient's megakaryocytes to produce platelets at a more rapid than normal rate, thus overwhelming the immune system's ability to destroy them. As doing so involves changes to the bone marrow chemistry, a number of potentially serious side-effects may develop, including death, myalgia, joint and extremity discomfort, insomnia, thrombocytosis, which may lead to potentially fatal clots, and bone marrow fibrosis, the latter which may result in an unsafe decrease in the red blood count.

On Dec, 30, 2015: 10,697 people reported to have side effects when taking Nplate. Among them, 1,170 people (10.94%) have Death.

Time on Nplate when people have Death  :

Gender of people who have Death when taking Nplate  :

Age of people who have Death when taking Nplate  :

Top conditions involved for these people  :

1. Idiopathic thrombocytopenic purpura (1,037 people, 88.63%)
2. Thrombocytopenia (95 people, 8.12%)
3. Myelodysplastic syndrome (20 people, 1.71%)
4. Chronic lymphocytic leukaemia (16 people, 1.37%)
5. Autoimmune thrombocytopenia (6 people, 0.51%)