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Diphenoxylate is the main active ingredient in Lomotil.   It  is metabolised in the body to yield difenoxin.

Diphenoxylate (brand name Diocalm), or diphenoxylate hydrochloride, is a centrally-active opioid drug of the phenylpiperidine series that is used for the treatment of diarrhea and has been used in IBS.

The Diphenoxylate-Loperamide subfamily of gastrointestinal drugs works directly on opioid receptors. Diphenoxylate itself crosses the blood-brain barrier. This being the case, this medication is potentially habit-forming and can generate significant tolerance if taken continuously for a protracted period.

Physical dependence is most common particularly with high doses and/or long-term use. The CNS penetration of diphenoxylate makes it an agent that can cause euphoria and other psychoactive effects, which could over time lead to habituation and dependency on the drug in the user.

“As with other medicinal opioids, addiction is uncommon although physical dependence secondary to treatment of a functional bowel disorder with diphenoxylate for more than 45–90 days may very well occur; it typically requires the use of high doses to impart a morbid seek orientation for the drug in the user”.

Because of this, diphenoxylate is manufactured and marketed as a combination drug with atropine as an abuse deterrent.  But…………..

“It has been stated that subtherapeutic amounts of atropine sulfate have been added to the compound to discourage deliberate overdosage This contention seems to conflict, however, with experimental data. Doses of less than 2 mg of atropine are, in an adult, unlikely to produce any clinically significant dysphoric effects. Therefore, even 60 tablets, which is a quantity significantly beyond that which is theoretically required to produce a morphine-like euphoria, would not contain a sufficient amount of atropine sulfate to disturb the patient sufficiently, presumably, to discourage deliberate overdosage. This is particularly true because many opiate abusers are characteristically willing to tolerate considerable amounts of distress to obtain their high, "paying the price" not only in physical discomfort, but often, ultimately, in the typical, erosive, downward-spiral of the addicts' life-style”.

Time on Lomotil when people have Hallucination  :

Gender of people who have Hallucination when taking Lomotil  :

Age of people who have Hallucination when taking Lomotil  :