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Observations placeholder

Eye diseases, depression and Cod liver oil



Type of Spiritual Experience


They didn't say which Vitamin B they gave, so I have been unable to do any linking

A description of the experience

Ocul Surf. 2014 Apr;12(2):134-45. doi: 10.1016/j.jtos.2013.09.002. Epub 2013 Dec 30.  Irritable eye syndrome: neuroimmune mechanisms and benefits of selected nutrients.  Feher J, Pinter E2, Kovács I3, Helyes Z2, Kemény A4, Markovics A4, Plateroti R5, Librando A5, Cruciani F5.   Ophthalmic Neuroscience Program, Department of Visual Science, Sapienza University of Rome, Italy; Nutripharma Hungaria Ltd, Budapest, Hungary. Electronic address: j.feher@libero.it. And Department of Pharmacology and Pharmacotherapy, University of Pecs, Hungary; PharmInVivo Ltd, Pecs, Hungary; Szentagothai Research Centre, University of Pecs, Hungary.  And Department of Ophthalmology, Semmelweis University, Budapest, Hungary.  Department of Pharmacology and Pharmacotherapy, University of Pecs, Hungary.  Ophthalmic Neuroscience Program, Department of Visual Science, Sapienza University of Rome, Italy.

Previous studies showed comorbidity of some ocular, enteral, and affective symptoms comprising irritable eye syndrome.

Aims of the present study were to learn more about the pathogenic mechanisms of this syndrome and to evaluate benefits of food supplements on these disorders.

In in vitro assay, Lactobacillus acidophilus lysate inhibited interleukin (IL)-1β and tumor necrosis factor (TNF)-α generation of lipopolysaccharide (LPS)-stimulated macrophages in dose- and size-dependent manner. For a prospective, open-label phase I/II controlled clinical trial, 40 subjects affected by ocular dysesthesia and hyperesthesia and comorbid enteral and anxiety-depression symptoms were randomly assigned either into the treated group, which received a composition containing probiotic lysate, vitamins A, B, and D and omega 3 fatty acids, or into the control group, which received vitamins and omega 3 fatty acids.

For reference, 20 age- and sex-matched healthy subjects were also selected. White blood count (WBC) and lymphocyte and monocyte counts, as well as IL-6 and TNF-α levels, were significantly above the reference levels in both treated and control groups.

After 8 weeks, WBC and lymphocyte and monocyte counts, and cytokine levels significantly decreased, and ocular, enteral, and anxiety-depression symptoms significantly improved in the treated group as compared to the control group.

This proof-of-concept study suggested that subclinical inflammation may be a common mechanism connecting ocular, enteral, and anxiety/depression symptoms, and supplements affecting dysbiosis may be a new approach to treating this syndrome.

Copyright © 2014. Published by Elsevier Inc.


TNF-α; anxiety; cod liver oil; constipation; depression; diarrhea; incontinence; interleukin (IL)-6; monocyte count; ocular dysesthesia; ocular hyperesthesia; probiotic lysate; vitamin B; white blood cell count

PMID:  24725325

The source of the experience


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