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Cancer, autoimmune disease and nanoparticles

Identifier

006335

Type of Spiritual Experience

None

Background

Not a spiritual experience but a paper linking cancer of various sorts as well as autoimmune disease to nanoparticles

 

A description of the experience

Nanoscale Res Lett. 2009 Sep 16;4(12):1409-20. doi: 10.1007/s11671-009-9413-8. The Influences of Cell Type and ZnO Nanoparticle Size on Immune Cell Cytotoxicity and Cytokine Induction.  Hanley C, Thurber A, Hanna C, Punnoose A, Zhang J, Wingett DG. Department of Biological Sciences, Boise State University, Boise, ID, 83725, USA. denisewingett@boisestate.edu.

...........ZnO nanoparticles of controlled size were synthesized, and their cytotoxicity toward different human immune cells evaluated.

A differential cytotoxic response between human immune cell subsets was observed, with lymphocytes being the most resistant and monocytes being the most susceptible to ZnO nanoparticle-induced toxicity.

Significant differences were also observed between previously activated memory lymphocytes and naive lymphocytes, indicating a relationship between cell-cycle potential and nanoparticle susceptibility.

Mechanisms of toxicity involve the generation of reactive oxygen species, with monocytes displaying the highest levels, and the degree of cytotoxicity dependent on the extent of nanoparticle interactions with cellular membranes.

An inverse relationship between nanoparticle size and cytotoxicity, as well as nanoparticle size and reactive oxygen species production was observed.

In addition, ZnO nanoparticles induce the production of the proinflammatory cytokines, IFN-γ, TNF-α, and IL-12, at concentrations below those causing appreciable cell death.

Collectively, these results underscore the need for careful evaluation of ZnO nanoparticle effects across a spectrum of relevant cell types when considering their use for potential new nanotechnology-based biological applications.

KEYWORDS:

Cytokine, Immunity, Monocytes, Nanoparticle, Nanotoxicity, T lymphocyte, ZnO

PMID: 20652105

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Nanoparticles

Activities and commonsteps

Commonsteps

References