Arsenic, selenium and Vitamin E
Type of Spiritual Experience
Arsenic [being a heavy metal] in toxic proportions affects selenium and vitamin E helps in reversing this.
A description of the experience
J Trace Elem Med Biol. 2014 Sep 3. pii: S0946-672X(14)00167-9. doi: 10.1016/j.jtemb.2014.08.013. [Epub ahead of print]
Effect of vitamin E supplementation on arsenic induced alteration in blood biochemical profile, oxidant/antioxidant status, serum cortisol level and retention of arsenic and selenium in goats.
Mohanta RK1, Garg AK2, Dass RS2.
- 1Mineral and Vitamin Nutrition Laboratory, Center of Advanced Faculty Training in Animal Nutrition, Indian Veterinary Research Institute, Izatnagar 243 122, India. Electronic address: email@example.com.
- 2Mineral and Vitamin Nutrition Laboratory, Center of Advanced Faculty Training in Animal Nutrition, Indian Veterinary Research Institute, Izatnagar 243 122, India.
Arsenic (As) exerts oxidative stress with depletion of body selenium in monogastric animals. But in ruminants this fact is not yet verified.
Vitamin E is an effective dietary antioxidant. Thus, in this experiment, the protective effect of vitamin E against arsenic toxicity induced by sodium arsenite (60mg As/kg diet) was investigated in goat kids. For this, 21 male kids were divided into three equal groups and
- fed either basal diet as such (control), or
- supplemented with 60mg As/kg diet and
- 60mg As/kg diet+250IU vitamin E/kg diet
for 180 days.
Vitamin E supplementation alleviated the toxic effects caused by arsenic on serum alanine aminotransferase and aspartate aminotransferase and lipid peroxidation. It also prevented the depletion of reduced glutathione content and reduction in activity of catalase, superoxide dismutase and glutathione-s-transferase in erythrocytes resulted from arsenic intoxication.
The elevated levels of arsenic and reduced levels of selenium in the serum and tissues in arsenic treated animals were attenuated by vitamin E supplementation, though not completely. However, serum cortisol level was not affected by arsenic.
It was concluded that arsenic exerts cortisol independent stressor mechanism and supplementation of vitamin E at a level of 250IU/kg diet was partially effective in reducing tissue accumulation of arsenic in the body and protect the kids from oxidative stress induced by arsenic.
Copyright © 2014 Elsevier GmbH. All rights reserved.
Arsenic toxicity; Arsenic–Selenium interaction; Goats; Oxidative stress; Vitamin E