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Apokyn also known as Apomorphine (Ixense, Spontane, Uprima) is a non-selective dopamine agonist which activates both D1-like and D2-like receptors, with some preference for the latter subtypes. It is historically a morphine decomposition product by boiling with concentrated acid, hence the -morphine suffix. Apomorphine does not actually contain morphine or its skeleton, nor does it bind to opioid receptors. The apo- prefix relates to it being an aporphine derivative.

Historically, apomorphine has been tried [sic] for a variety of uses including psychiatric treatment of homosexuality [sic] in the early 20th century, and more recently in treating erectile dysfunction. Currently, apomorphine is used in the treatment of Parkinson's disease. It is a potent emetic (i.e., it induces vomiting)

The emetic properties of apomorphine are exploited in veterinary medicine to induce therapeutic emesis in canines that have recently ingested toxic or foreign substances.

It was also used as an unofficial treatment of heroin addiction, a purpose for which it was championed by the author William S. Burroughs.  There is, however, no clinical evidence that apomorphine is an effective and safe treatment regimen for opiate addiction. Early studies involved aversion therapy in alcoholism and anxiety, and modern reports are anecdotal.

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On Oct, 8, 2015: 396 people reported to have side effects when taking Apokyn. Among them, 16 people (4.04%) have Death.

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