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Antimicrobial activity of Wedelia trilobata crude extracts



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Proteus vulgaris is a rod-shaped, nitrate-reducing, indole+ and catalase-positive, hydrogen sulfide-producing, Gram-negative bacterium that inhabits the intestinal tracts of humans and animals. It can be found in soil, water, and fecal matter. It is grouped with the Enterobacteriaceae and is an opportunistic pathogen of humans. It is known to cause wound infections and other species of its genera are known to cause urinary tract infections.

Pseudomonas aeruginosa is a common Gram-negative rod-shaped bacterium that can cause disease in plants and animals, including humans. A species of considerable medical importance, P. aeruginosa is a prototypical "multi drug resistant (MDR) pathogen" that is recognised for its ubiquity, its intrinsically advanced antibiotic resistance mechanisms, and its association with serious illnesses - especially nosocomial infections such as ventilator-associated pneumonia and various sepsis syndromes.

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Phytomedicine. 1999 May;6(2):133-4.

Antimicrobial activity of Wedelia trilobata crude extracts.

Taddei A1, Rosas-Romero AJ.

  • 1Departamento de Química, Universidad Simón Bolívar, Caracas, Venezuela.


A biological screening of activity against Gram-positive and Gram-negative bacteria, yeasts, and fungi of crude extracts from Wedelia trilobata is reported.

The n-hexane extract showed antibacterial activity against Bacillus subtilis, Mycobacterium smegmatis, Staphylococcus aureus, and Staphylococcus epidermidis (Gram-positive bacteria); along with Proteus vulgaris, Pseudomonas aeruginosa, Salmonella group C, Salmonella paratyphi, and Shigella sonnei (Gram-negative bacteria).

The ethyl acetate extract was active only against Salmonella group C; and the aqueous extract was inactive against the tested bacteria.

None of the tested extracts showed biological activity against the yeasts (Candida albicans, Candida tropicalis, Rhodotorula rubra) or the fungi (Aspergillus flavus, Aspergillus niger, Mucor sp., Trichophyton rubrum).



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