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Observations placeholder

Avastin and Bevacizumab

Identifier

017612

Type of Spiritual Experience

Hallucination

Number of hallucinations: 96

Background

A description of the experience

Bevacizumab  trade name Avastin, Genentech is an angiogenesis inhibitor, a drug that slows the growth of new blood vessels.

Bevacizumab is a recombinant humanized monoclonal antibody that blocks angiogenesis by inhibiting vascular endothelial growth factor A (VEGF-A).[2] VEGF-A is a chemical signal that stimulates angiogenesis in a variety of diseases.

Bevacizumab was approved by the U.S. Food and Drug Administration (FDA) for certain metastatic cancers. It received its first approval in 2004, for combination use with standard chemotherapy for metastatic colon cancer. It has since been approved for use in certain lung cancers, renal cancers, ovarian cancers, and glioblastoma multiforme of the brain. It had been approved for breast cancer, but that approval was withdrawn when later studies showed no evidence of effectiveness.

 It is also listed for its use in treating certain eye diseases

Many diseases of the eye, such as age-related macular degeneration (AMD) and diabetic retinopathy, damage the retina and cause blindness when blood vessels around the retina grow abnormally and leak fluid, causing the layers of the retina to separate. This abnormal growth is caused by VEGF, so bevacizumab is used to inhibit VEGF and slow this growth.

Bevacizumab has recently been used by ophthalmologists in an off-label [sic] use as an intravitreal agent in the treatment of proliferative (neovascular) eye diseases, particularly for choroidal neovascular membrane (CNV) in AMD.

Although not currently approved by the FDA for such use, the injection of 1.25-2.5 mg of bevacizumab into the vitreous cavity has been used

Results show similar outcomes using either bevacizumab or ranibizumab

Clinical trials are underway to test an intra-arterial technique for delivering the drug directly to brain tumors, bypassing the blood–brain barrier.

For treatment of eye diseases it is injected intravitreously.

 

On Dec, 29, 2016 42,902 people reported to have side effects when taking Avastin.
Among them, 96 people (0.22%) have Hallucination

Time on Avastin when people have Hallucination  :

  < 1 month 1 - 6 months 6 - 12 months 1 - 2 years 2 - 5 years 5 - 10 years 10+ years
Hallucination 60.00% 0.00% 0.00% 40.00% 0.00% 0.00% 0.00%

 

 On Dec, 23, 2016 42,902 people reported to have side effects when taking Avastin.
Among them, 9,896 people (23.07%) have Death

Time on Avastin when people have Death  :

  < 1 month 1 - 6 months 6 - 12 months 1 - 2 years 2 - 5 years 5 - 10 years 10+ years
Death 41.78% 37.56% 8.92% 6.81% 4.93% 0.00% 0.00%

Gender of people who have Death when taking Avastin  :

  Female Male
Death 55.78% 44.22%

Age of people who have Death when taking Avastin :

  0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Death 0.12% 0.12% 0.37% 0.62% 5.07% 20.02% 21.88% 51.79%

The source of the experience

eHealthme

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Commonsteps

References