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Cadmium poisoning and selenium
Identifier
013088
Type of Spiritual Experience
Background
Cadmium reduces selenium levels, which has a host of knock on effects and thus selenium in the diet should help to counter the effects of this toxicity.
A eukaryote is any organism whose cells contain a nucleus and other structures (organelles) enclosed within membranes. The endoplasmic reticulum (ER) is a type of organelle in the cells of eukaryotic organisms that forms an interconnected network of flattened, membrane-enclosed sacs or tubes known as cisternae. The membranes of the ER are continuous with the outer membrane of the nuclear envelope. Endoplasmic reticulum occurs in most types of eukaryotic cells, including the most primitive Giardia, but is absent from red blood cells and spermatozoa.
A description of the experience
Biol Trace Elem Res. 2014 Dec;161(3):328-33. doi: 10.1007/s12011-014-0135-0. Epub 2014 Oct 5.
Four endoplasmic reticulum resident selenoproteins may be related to the protection of selenium against cadmium toxicity in chicken lymphocytes.
Zhao W1, Liu W, Chen X, Zhu Y, Zhang Z, Yao H, Xu S.
- 1College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
Cadmium could induce the damage of endoplasmic reticulum.
In the present study, we investigated the effect of Cadmium on messenger RNA expressions of endoplasmic reticulum resident selenoproteins, selenoprotein K, selenoprotein N, selenoprotein S, and selenoprotein T, in cultured chicken lymphocytes and the antagonistic effect of Selenium.
Chicken splenic lymphocytes were treated with 10(-7) mol/L Selenium, 10(-6) mol/L Cadmium, and the mixture of 10(-6) mol/L Selenium and 10(-7) mol/L Cadmium in the culture medium for 12, 24, 36, and 48 h, respectively. Then, we detected the messenger RNA expressions of selenoprotein K, selenoprotein N, selenoprotein S, and selenoprotein T by using real-time polymerase chain reaction method.
The results indicated that Selenium significantly increased the expressions of selenoprotein K, selenoprotein N, selenoprotein S, and selenoprotein T, which were reduced by Cadmium in chicken splenic lymphocytes.
It indicated that endoplasmic reticulum was one target of Cadmium toxication, and Cadmium toxicity might be related to the reduced expressions of selenoprotein K, selenoprotein N, selenoprotein S, and selenoprotein T in chicken lymphocytes.
Selenium reserved the protective role by increasing the expressions of selenoprotein K, selenoprotein N, selenoprotein S, and selenoprotein T. The present study provided a useful clue to investigate the possible pathogenesis of Cadmium toxicity.
PMID: 25283511