Symbols - What does heaven look like
Two and two is IIII – four pillars. Twenty two is the end of the number system and is thus also the end of an old era. It may or may not be the beginning of a new era/increment of evolution. In a practical sense, if it is a changeover period, it is a time of considerable change, much destruction followed by the introduction of much that is new.
In those systems that use this nomenclature, whereas Alpha  is the beginning, Omega  is symbolically ‘the End’.
There is the added symbolism that 22 = 10 + 12
Thus perfection achieved through the Great Work, - completion through to perfection of a cycle of the wheel of change.
This can apply to anything - a business, a world system or a person on the spiritual path. The Fool or The Jester is one of the 78 cards in a Tarot deck; one of the 22 Trump cards that make up the Major Arcana. The Fool is unnumbered; sometimes represented as 0 (the first) or more generally XXII (the last) Major Arcana in decks.
Thus a Fool is a person who has achieved perfection through the Great Work, - completion of their destiny and completion through to perfection of a cycle of the wheel of change.