Some science behind the scenes
SNRIs are serotonin-norepinephrine reuptake inhibitor (SNRI) - used for major depressive disorder, generalized anxiety disorder, fibromyalgia and neuropathic pain, obesity plus a number of other complaints, some are also anti-histamines. Examples include
- Duloxetine (Cymbalta, and generics) - Duloxetine failed to receive US approval for stress urinary incontinence amid concerns over liver toxicity and suicidal events; however, it was approved for this indication in the UK
- Sibutramine - an obesity drug which has been withdrawn from the market in several countries because of its association with increased cardiovascular events and strokes.
- Milnacipran (Ixel, Savella, Dalcipran, Toledomin) is used in the clinical treatment of fibromyalgia. It is not approved for depression in the USA, but it is in other countries.
- Chlorpheniramine - In addition to being an histamine H1 receptor antagonist, chlorphenamine is a serotonin-norepinephrine reuptake inhibitor or SNRI
- Cocaine - non-selectively inhibits the reuptake of serotonin, norepinephrine, and dopamine.
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