Some science behind the scenes

Bromo-DragonFLY

The following description was extracted from Wikipedia

 Bromo-DragonFLY is a generally illegal hallucinogenic drug related to the phenethylamine family.  It got its name from an earlier and less active dihydrofurane series of compounds nicknamed FLY due to the molecule's superficial structural resemblance to a fly.

 It is considered an extremely potent hallucinogen, only slightly less potent than LSD with a normal dose in the region of 200 μg to 800 μg.  Bromo-DragonFLY has about 300 times the potency of mescaline, or 1/5th the potency of LSD.

It has an extremely long duration of action - up to several days, often  2–3 days following a single large dose, with a slow onset of action that can take up to 6 hours before the effects are felt.

The hallucinogenic effect of bromo-DragonFLY is mediated by its agonist activity at the 5-HT2A serotonin receptor. Bromo-DragonFLY also has a high binding affinity for the 5-HT2B and 5-HT2C serotonin receptors, and is most accurately described as a non-subtype selective 5-HT2 agonist, as it is actually twice as potent an agonist for 5-HT2C receptors as for 5-HT2A, as well as being less than 5x selective for 5-HT2A over 5-HT2B.

It has been sold in the form of blotters, similar to the distribution method of LSD, which has led to confusion, and adverse reactions.  The toxicity of Bromo-DragonFLY is fairly high when taken in doses above the therapeutic range, with reports of several deaths.

It has also been the subject of mislabelling.  Laboratory testing has confirmed that in October 2009, a batch of Bromo-Dragonfly was distributed, mislabeled as the related compound 2C-B-FLY, which is around 20x less potent than BDF by weight. This mistake is believed to have contributed to several lethal overdoses and additional hospitalizations. The batch implicated in these deaths also contained significant synthesis impurities, which may have contributed to the toxicity.

A Swedish man had to have the front part of his feet and several fingers on one hand amputated after taking a massive overdose. Apparently the compound acted as a long-acting vasoconstrictor, leading to necrosis and gangrene which continued several weeks after the overdose occurred. Several other cases have also been reported of severe peripheral vasoconstriction following overdose with Bromo-DragonFLY.

Other cases of overdose, disturbing experiences, and Bromo-DragonFLY associated health problems have been described. Seizures have been reported.

October 3, 2009 a 22 year old man from Copenhagen died after ingesting Bromo-dragonfly. His friend described the trip saying, "It was like being dragged to hell and back again. Many times. It is the most evil [thing] I've ever tried. It lasted an eternity"

 References

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