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Ziprasidone (marketed as Geodon, Zeldox  and Zipwell ) was the fifth atypical antipsychotic to gain approval (February 2001) in the United States. It is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia, and acute mania and mixed states associated with bipolar disorder. Its intramuscular injection form is approved for acute agitation in schizophrenic patients for whom treatment with just ziprasidone is appropriate. Ziprasidone is also used off-label for depression, bipolar maintenance, and PTSD

Adverse effects

Ziprasidone received a black box warning due to increased mortality in elderly patients with dementia-related psychosis.  Note: The percentages given are incidences of respective adverse effects.

Very common adverse effects (>10%)

• Somnolence
• Headache

Common adverse effects (1-10%)

• Hypersalivation
• Respiratory disorders
• Nausea
• Vomiting
• Dry mouth
• Constipation
• Dyspepsia
• Dizziness
• Extrapyramidal symptoms (EPS) such as: (in a recent meta-analysis of 15 antipsychotic drugs it came 8th for extrapyramidal side effects
• Tremor
• Dystonia
• Akathisia
• Muscle rigidity
• Rash
• Tachycardia
• Orthostatic hypotension
• Diarrhea
• Anorexia
• Myalgia
• Rhinitis
• Cough
• Anxiety
• Abnormal vision
• Spasmodic movement
• Asthenia
• Weight gain (usually less prominent than with other atypical antipsychotics, as is supported by a recent meta-analysis in which it produced the 2nd least weight gain, after haloperido)

Uncommon (0.1-1%) adverse effects

• Abnormal gait
• Thirst
• Palpitation
• Hyperprolactinaemia (according to a recent meta-analysis of 15 atypical antipsychotics it produces less prolactin elevation than risperidone, paliperidone, haloperidol, sertindole and lurasidone[29])
• Dysphagia
• Flatulence
• Gastritis
• Tinnitus
• Photophobia
• Hepatic enzyme increased
• Increased appetite
• Heart rate increased
• Rhinitis
• Joint stiffness
• Muscle cramps
• Pain in extremity
• Ataxia
• Bradykinesia
• Cogwheel rigidity
• Disturbance in attention
• Drooling
• Dysarthria
• Generalised tonic-clonic seizures
• Hypokinesia
• Hypersomnia
• Hypoaesthesia
• Lethargy
• Oculogyric crisis
• Paraesthesia
• Tardive dyskinesia
• Vertigo
• Throat tightness
• Nightmares
• Dyspnoea
• Sore throat
• Dysuria
• Urinary incontinence
• Acne
• Maculopapular rash
• Rash
• Urticaria

Rare (<0.1%) side effects

• Drug Reaction with Eosinophilia and Systemic Symptoms
• Chest pain
• Feeling hot
• Pyrexia
• Sluggishness
• Gastroesophageal reflux
• Loose stools
• Lymphocytopenia
• Ear pain
• Positional vertigo
• Amblyopia
• Eye pruritus
• Visual disturbance
• Blood lactic dehydrogenase increased
• Body temperature increased
• QT interval prolongation
• Eosinophilia
• Hypocalcaemia
• Liver function test abnormal
• Increased pulse
• Arthropathy
• Musculoskeletal discomfort
• Trismus
• Akinesia
• Paresis
• Restless legs syndrome
• Torticollis
• Anorgasmia
• Bradyphrenia
• Flat affect
• Panic attack

Time on Ziprasidone hydrochloride when people have Hallucination  :

On Feb, 25, 2016: 480 people reported to have side effects when taking Ziprasidone hydrochloride. Among them, 20 people (4.17%) have Death.

Time on Ziprasidone hydrochloride when people have Death  :