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Observations placeholder

Transient psychosis in women on clomiphene, bromocriptine, domperidone and related endocrine drugs

Identifier

017898

Type of Spiritual Experience

Hallucination

Number of hallucinations: 1

Background

Domperidone is "given in order to relieve nausea and vomiting; to increase the transit of food through the stomach (as a prokinetic agent through increase in gastrointestinal peristalsis); and to increase lactation (breast milk production) by release of prolactin".

A description of the experience

Gynecol Endocrinol. 2015 Aug 19:1-4. [Epub ahead of print]

Transient psychosis in women on clomiphene, bromocriptine, domperidone and related endocrine drugs.

Seeman MV1.

  • 1a Department of Psychiatry , University of Toronto , Toronto , ON , Canada.

Abstract

BACKGROUND:

There have been reports of transient psychosis in women medicated for gynecologic conditions.

OBJECTIVE:

The aim of this paper was to explore this literature.

METHOD:

The PubMed and Google Scholar databases were searched for relevant case reports Results: The following reports were found: psychosis induced by gonadotropin-releasing hormone in the treatment of endometriosis, by clomiphene treatment for infertility, by bromocriptine treatment for milk suppression and by the withdrawal of domperidone prescribed as a galactologue as well as by the withdrawal of estrogen replacement therapy.

CONCLUSION:

In susceptible women, psychotic symptoms can result from treatments that reduce estrogen levels, such as leuprolide acetate or clomiphene, or treatments that increase dopamine levels (bromocriptine). Psychosis can also be caused indirectly when estrogen treatment is discontinued or dopamine antagonism (e.g. domperidone) withdrawn. Estrogen-reducing and dopamine-increasing treatments used in gynecology need to be carefully monitored.

KEYWORDS:

Bromocriptine; clomiphene; domperidone; dopamine; estrogen; leuprolide acetate

PMID: 26291819

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Commonsteps

References