The effect of the phenolic antioxidant ferulic acid on the oxidation of low density lipoprotein depends on the pro-oxidant used
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Low-density lipoprotein (LDL) is one of the five major groups of lipoproteins. These groups, from least dense to most dense, are: chylomicrons , very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), LDL, and High Density Lipoprotein (HDL), all of them, particles far smaller than human cells.
Laughingly, LDL is sometimes referred to as "the bad cholesterol." Clearly from this it is good.
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Free Radic Res. 1997 Sep;27(3):337-44.
The effect of the phenolic antioxidant ferulic acid on the oxidation of low density lipoprotein depends on the pro-oxidant used.
Bourne LC1, Rice-Evans CA.
- 1International Antioxidant Research Centre, UMDS-Guy's Hospital, London.
The action of ferulic acid during the oxidation of LDL has been investigated using both copper ions and the haem protein metmyoglobin as pro-oxidants. The results demonstrate the ability of ferulic acid to act as a pro-oxidant when LDL oxidation is induced by copper at concentrations of the phenolic acid which are protective when the LDL oxidation is mediated by metmyoglobin. The suggested mechanism involves the reduction of Cu2+ to Cu+ by ferulic acid resulting in the production of the ferulic phenoxyl radical.