Tannin inhibits HIV-1 entry by targeting gp41
Type of Spiritual Experience
A description of the experience
Acta Pharmacol Sin. 2004 Feb;25(2):213-8.
Tannin inhibits HIV-1 entry by targeting gp41.
Lü L1, Liu SW, Jiang SB, Wu SG.
- 1Institute of Pharmaceutical Sciences of the First Medical University of PLA, Key Lab of GD for Screening of New Drug, Guangzhou, Guangdong 510515, China.
To investigate the mechanism by which tannin inhibits HIV-1 entry into target cells.
The inhibitory activity of tannin on HIV-1 replication and entry was detected by p24 production and HIV-1-mediated cell fusion, respectively. The inhibitory activity on the gp41 six-helix bundle formation was determined by an improved sandwich ELISA.
Tannins from different sources showed potent inhibitory activity on HIV-1 replication, HIV-1-mediated cell fusion, and the gp41 six-helix bundle formation.
Tannin inhibits HIV-1 entry into target cells by interfering with the gp41 six-helix bundle formation, thus blocking HIV-1 fusion with the target cell.