Observations placeholder

Silver sulfadiazine (INN, or silvadene) is a topical sulfonamide/silver antibacterial used as a topical cream on burns. Evidence regarding its usefulness in burns is poor. Tentative evidence has found that silver sulfadiazine may increase healing times – wounds may take longer to heal if treated with this drug, so it is not recommended by the authors of a Cochrane review.

Silver sulfadiazine is typically delivered in a cream or aqueous suspension.

Adverse effects

A non infection related clear fluid may form on the wound's surface. Burning and painful sensations are not uncommon but only temporary.

About 0.1 to 1.0% of people show hypersensitivity reactions such as rashes or erythema multiforme. This reaction is known from other sulfonamides including antibacterials, thiazide diuretics, and sulfonylurea antidiabetics; but data on the likelihood of cross-allergies are inconsistent.

Incorporation of the silver ions can lead to local argyria (discoloration of the skin), especially if the treated area is exposed to ultraviolet light. Generalised argyria with silver accumulation in kidneys, liver, and retina has only been found in association with excessive long-term use, or repeated use on severe and heavily inflamed burns. Possible consequences of generalised argyria include interstitial nephritis and anemia.

On Feb, 8, 2016: 287 people reported to have side effects when taking Silvadene. Among them, 3 people (1.05%) have Hallucination.

On Feb, 8, 2016: 287 people reported to have side effects when taking Silvadene. Among them, 16 people (5.57%) have Death.