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Scotch thistle root and cancer

Identifier

017236

Type of Spiritual Experience

Background

A description of the experience

Nat Prod Commun. 2014 Mar;9(3):337-40.

Bioactivity-guided isolation of antiproliferative compounds from the roots of Onopordum acanthium.

Csupor-Löffler B, Zupkó I, Molnár J, Forgo P, Hohmann J.

Onopordum acanthium has been considered in traditional medicine to be effective against different cancers.

The chloroform extracts of the root, which displayed antiproliferative effect against human tumor cell lines, was subjected to bioactivity-guided multistep chromatographic separation.

This experiment resulted in the isolation of the sesquiterpene lactones

  • 4beta,14-dihydro-3-dehydrozaluzanin C (1),
  • zaluzanin C (2) and
  • 4beta,15,11beta,13-tetrahydrozaluzanin C (3),
  • the neolignan nitidanin-diisovalerianate (4), besides
  • 13-oxo-9Z,11 E-octadecadienoic acid (5),
  • 24-methylenecholesterol (6),
  • alpha-linolenic acid,
  • linoleic acid,
  • stigmasterol and
  • beta-sitosterol.

The structures of the isolated compounds were established through analytical data (NMR, MS), and by comparison of these with those reported in the literature. All the aforementioned compounds were detected for the first time from this plant.

The antiproliferative activities of compounds 1-6 were assessed on cervix adenocarcinoma HeLa, breast adenocarcinoma MCF7 and skin epidermoid carcinoma A431 cells by using the MTT assay. It was found that, 4beta,14-dihydro-3-dehydrozaluzanin C (1), the most active antiproliferative compound of the extract, exerted remarkable tumor cell growth inhibitory activity (IC50 2.7-15.1 microM).

PMID:  24689209

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Activities

Overloads

Cancer

Suppressions

ALA
Linoleic acid
Scotch thistle

Commonsteps

References