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Pilot study of the effect of raubasine on platelet biological activity



Type of Spiritual Experience


Rauvolfia serpentina, or Indian snakeroot or sarpagandha, is a species of flowering plant in the family Apocynaceae. It is native to the Indian Subcontinent and East Asia (from India to Indonesia).  Common English names : Devil-pepper, Snake-root.

Ajmaline is also an alkaloid that is class Ia antiarrhythmic agent. It is often used to bring out typical findings of ST elevations in patients suspected of having Brugada syndrome. See

Kiesecker, C.; Zitron E.; Lück S.; Bloehs R.; Scholz E.P.; Kathöfer S.; Thomas D.; Kreye V.A.; Katus H.A.; Schoels W.; Karle C.A.; Kiehn J.. (2004). "Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action.". Naunyn Schmiedebergs Arch Pharmacol. 370 (6): 423–35. PMID 15599706.

A description of the experience

Arzneimittelforschung. 1986 Sep;36(9):1394-8.

Pilot study of the effect of raubasine on platelet biological activity.

Neuman J, de Engel AM, Neuman MP.

A pilot study was carried out to determine the action of raubasine (ajmalicine) an alkaloid derived from Rauwolfia serpentina [and Kratom], on platelet biological function in 14 patients selected because they were at risk due to complications of atherosclerosis. The determinations of platelet aggregation were done ex vivo and the following substances were used as inducing agents: adenosine diphosphate (2.5 and 5.0 X 10(-6) mol/l), collagen (0.05 mg/ml), and epinephrine (adrenaline) (1.68 X 10(-4) mol/l). 12 out of the 14 patients treated showed a reduction in platelet aggregation in at least 2 of the 3 test curves. This reduction was statistically significant for collagen (p less than 0.02) and epinephrine (p less than 0.01). A statistically significant (p less than 0.05) prolongation of the latency period of aggregation produced by collagen was found in 12 out of 14 patients and a prolongation of recalcification time produced by the reduction in platelet factor 3 was found in 9 out of 14 patients. In addition to the fact that the effect of a reduction in platelet aggregation was more evident in the second wave, these results suggest that raubasine has an inhibitory action on the release reaction of the platelets. The results obtained merit further study to confirm this property of the drug.

PMID:  3790193

The source of the experience


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