Persistent interferon-ß-1b-induced psychosis in a patient with multiple sclerosis
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A description of the experience
Psychiatry Clin Neurosci. 2010 Oct;64(5):584-6.
Persistent interferon-ß-1b-induced psychosis in a patient with multiple sclerosis.
Manfredi G1, Kotzalidis GD, Sani G, Koukopoulos AE, Savoja V, Lazanio S, Girardi N, Tatarelli R.
- 1Psychiatric Unit, Department of Neurosciences, Mental Health and Sensory Functions (NESMOS), Sapienza University, 2nd Medical School, Sant' Andrea Hospital, Rome, Italy. firstname.lastname@example.org
Interferon-ß is used in patients with multiple sclerosis to reduce autoimmunity; although other psychiatric side-effects are common, in contrast to interferon-alpha, psychosis has been reported only once.
A patient with multiple sclerosis developed auditory hallucinations, paranoid delusions, and increased aggressiveness after 16 months of treatment with interferon-ß-1b, 250 mg every other day.
He responded after about one month to antipsychotic treatment, but tended to relapse upon dose reduction, and after 2 years still needs antipsychotics to control his symptoms. Because there was no change in his magnetic resonance imaging between pre- and post-treatment with interferon, we concluded that psychosis was more related to interferon treatment than to the underlying disease.
The source of the experiencePubMed
Concepts, symbols and science items
Activities and commonsteps
Multiple sclerosis treatments
Viral infection - Interferon drugs