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Orphenadrine (sold under the brand names Norflex, Mephenamin, Disipal, Banflex, Flexon, Biorphen, Brocasipal, Dolan, Norgesic, OrfenAce, and others) is an anticholinergic drug of the ethanolamine antihistamine class with prominent central nervous system (CNS) and peripheral actions used to treat painful muscle spasms and other similar conditions, as well as the treatment of some aspects of Parkinson's disease. It is closely related to diphenhydramine. Therefore, it is related to other drugs used for Parkinson's, such as benztropine and trihexyphenidyl, and it is also structurally related to nefopam, which is a centrally acting yet nonopioid analgesic. The combination of anticholinergic effects and CNS penetration make orphenadrine useful for pain of all etiologies, including from: radiculopathy, muscles, and headaches [sic]. Orphenadrine has about 58% of the anticholinergic potency of atropine at equivalent doses.

Orphenadrine is most often used against pain and muscle spasm of various etiologies, including lumbago, sciatica, and injury. It is qused for allergic symptoms and other histamine-related effects, such as those from hay fever, other allergies, and histamine release from many opioid analgesics.

The orphenadrine salt used for Parkinsonism is the hydrochloride, whereas the muscle relaxant tablet is the citrate. The manufacturers' descriptions of orphenadrine indicate the salts are not interchangeable; one reason may be that the citrate can be irritating when injected.

Euphoria is an effect reported by many patients, and orphenadrine has been investigated for use against depression, as first reported in June 1958 in the American Journal of Psychiatry

Like many first-generation antihistamines and chemically similar anticholinergics, orphenadrine can also cause excitement and insomnia, particularly in children and the elderly. Orphenadrine also works on smooth muscle in a manner identical to that of dicyclomine, brand name Bentyl, and will affect irritable bowel syndrome in a similar fashion.

On Jan, 21, 2016: 796 people reported to have side effects when taking Norflex. Among them, 18 people (2.26%) have Hallucination.

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On Jan, 16, 2016: 796 people reported to have side effects when taking Norflex. Among them, 3 people (0.38%) have Death.