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Ciclosporin, also spelled cyclosporine and cyclosporin, is an immunosuppressant medication and natural product. It is used by mouth and injection into a vein for rheumatoid arthritis, psoriasis, Crohn's disease, nephrotic syndrome, and in organ transplants to prevent rejection. It is also used as eye drops for keratoconjunctivitis sicca (dry eyes).

Common side effects include high blood pressure, headache, kidney problems, increased hair growth, and vomiting. Other severe side effects include an increased risk of infection, liver problems, and an increased risk of lymphoma. Blood levels of the medication should be checked to decrease the risk of side effects. Use during pregnancy may result in preterm birth; however, it does not appear to cause birth defects.

Ciclosporin is believed to work by decreasing the function of lymphocytes. It does this by forming a complex with cyclophilin to block the phosphatase activity of calcineurin that in turn decreases the production of inflammatory cytokines by T‐lymphocytes.

Ciclosporin was isolated in 1971 from the fungus Tolypocladium inflatum and came into medical use in 1983.

Most common Neoral side effects from eHealthme

• Fever - (1,736 reports)
• Blood creatinine increased - (1,455 reports)
• Thrombocytopenia - (810 reports)
• Renal impairment - (794 reports)
• Renal failure acute - (688 reports)
• Cytomegalovirus infection - (665 reports)
• Pneumonia - (646 reports)
• Diarrhea - (631 reports)
• High blood pressure - (631 reports)
• Kidney transplant rejection - (609 reports)

On Jan, 18, 2017  16,420 people reported to have side effects when taking Neoral.
Among them, 452 people (2.75%) have Death

On Jan, 18, 2017  16,420 people reported to have side effects when taking Neoral.  Among them, 59 people (0.36%) have Hallucination

On Feb, 07, 2017  16,420 people reported to have side effects when taking Neoral.  Among them, 38 people (0.23%) have Hallucination, Auditory