Inhibitory effects on the digestive enzyme alpha-amylase of three Salsola species (Chenopodiaceae) in vitro
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Pharmazie. 2007 Jun;62(6):473-5. Inhibitory effects on the digestive enzyme alpha-amylase of three Salsola species (Chenopodiaceae) in vitro. Tundis R1, Loizzo MR, Statti GA, Menichini F.
1Department of Pharmaceutical Sciences, University of Calabria, Rende, Italy. firstname.lastname@example.org
Hypoglycaemic effects of Salsola kali, S. soda, and S. oppositifolia (Chenopodiaceae) aerial parts were examined using in vitro assay based on the inhibition of a-amylase. The S. kali ethyl acetate fraction was the most active with a C1050 value 0.022 mg/ml. Through bioassay-guided fractionation processes two flavonol glycosides, isorhamnetin-3-O-glucoside and isorhamnetin-3-O-rutinoside, were isolated by silica gel column chromatography and characterized by spectroscopic methods. Isorhamnetin-3-O-rutinoside showed an interesting activity (IC50 0.129 mM).