Histidine deficiency, histamine deficiency and narcolepsy
Type of Spiritual Experience
Histidine deficiency results in histamine deficiency
Histamine deficiency caauses the body to increase the receptors in key areas in order that what histamine there is is captured, thus the brain is one key area as histamine controls the sleep wake cycle
Disruption of the sleep wake cycle causes narcolepsy
Anti-histames of all sorts also cause a histamine deficiency, therefore anti-histamines can be one cause of narcolepsy.
Thus to treat narcolepsy one must stop all use of anti-histamines and boost the intake of histidine rich foods.
A description of the experience
Ann Neurol. 2013 Dec;74(6):786-93. doi: 10.1002/ana.23968. Epub 2013 Sep 10.
Greatly increased numbers of histamine cells in human narcolepsy with cataplexy.
John J1, Thannickal TC, McGregor R, Ramanathan L, Ohtsu H, Nishino S, Sakai N, Yamanaka A, Stone C, Cornford M, Siegel JM.
To determine whether histamine cells are altered in human narcolepsy with cataplexy and in animal models of this disease.
Immunohistochemistry for histidine decarboxylase (HDC) and quantitative microscopy were used to detect histamine cells in human narcoleptics, hypocretin (Hcrt) receptor-2 mutant dogs, and 3 mouse narcolepsy models: Hcrt (orexin) knockouts, ataxin-3-orexin, and doxycycline-controlled-diphtheria-toxin-A-orexin.
We found an average 64% increase in the number of histamine neurons in human narcolepsy with cataplexy, with no overlap between narcoleptics and controls. However, we did not see altered numbers of HDC cells in any of the animal models of narcolepsy.
Changes in histamine cell numbers are not required for the major symptoms of narcolepsy, because all animal models have these symptoms. The histamine cell changes we saw in humans did not occur in the 4 animal models of Hcrt dysfunction we examined. Therefore, the loss of Hcrt receptor-2, of the Hcrt peptide, or of Hcrt cells is not sufficient to produce these changes. We speculate that the increased histamine cell numbers we see in human narcolepsy may instead be related to the process causing the human disorder. Although research has focused on possible antigens within the Hcrt cells that might trigger their autoimmune destruction, the present findings suggest that the triggering events of human narcolepsy may involve a proliferation of histamine-containing cells. We discuss this and other explanations of the difference between human narcoleptics and animal models of narcolepsy, including therapeutic drug use and species differences.
© 2013 American Neurological Association.
The source of the experiencePubMed
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