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Dr Duke’s List of Chemicals and their Biological Activities in: Rauvolfia vomitoria AFZEL. (Apocynaceae) -- African Snakeroot

Identifier

027914

Type of Spiritual Experience

Background

A description of the experience

Dr Duke’s List of Chemicals and their Biological Activities in: Rauvolfia vomitoria AFZEL. (Apocynaceae) -- African Snakeroot


Chemicals

17-ACETYL-AJMALINE Plant: DUKE1992A

No activity reported.

AJMALICINE Root: DUKE1992A

Adrenolytic HH2 ; Antiadrenergic WOI ; Antiaggregant EMP5:344 ; Antidiuretic HDN ; Antihypertensive JBH ; Cerebrocirculant JBH ; Circulotonic HDN ; CNS-Depressant; Hypotensive HH2 ; Sympatholytic HH2 ; Tranquilizer JBH

AJMALINE Root: DUKE1992A

Adrenolytic HH2 ; Allergenic M&R107 ; Antiarrhythmic 200-300 mg/orl/man/day; Antihypertensive; Antihypertonic HH2 ; Calcium-Antagonist gpg K26031 ; Cardiodepressant WOI ; Cardiotoxic M29 ; Convulsant HDN ; Coronary-Dilator JBH ; Hypotensive; Myocardiodepressant DUKE1992B ; Neurotoxic JNP59:890 ; Peristaltic WOI ; Respirastimulant WOI ; Tranquilizer NIG

AJMALININE Root: DUKE1992A

Hypotensive WOI ; Nephrovasodilator WOI ; Sympatholytic WOI

ALPHA-YOHIMBINE Plant: DUKE1992A

Antimalarial IC50=>200 uM RAS ; Antiplasmodial RAS

ALSTONINE Root: DUKE1992A

Antiamebic MPT ; Antibacterial DUKE1992B ; Antineoplastic JBH ; Fungicide 452 ; Pesticide DUKE1992B

ARICINE Leaf: DUKE1992A

(-)-Chronotropic HDN ; Amebicide IC50=3.6 ug/ml NIG ; Cytotoxic IC50=>100 ug/ml NIG ; Pesticide DUKE1992B

CARAPANAUBINE Leaf: DUKE1992A

No activity reported.

DEACETYLDEFORMYLAKUAMMILINE Plant: DUKE1992A

No activity reported.

DEACETYLDEFORMYLPICRALINE Plant: DUKE1992A

No activity reported.

ISOAJMALINE Root: DUKE1992A

No activity reported.

ISOCARAPANAUBINE Plant: DUKE1992A

No activity reported.

ISORESERPILINE Leaf: DUKE1992A

Cardiotoxic DUKE1992B ; CNS-Depressant DUKE1992B ; Hypotensive 5 mg/kg ivn mus DUKE1992B ; Parasympathetic DUKE1992B

ISORESERPILINE-PSEUDOINDOXYL Leaf: DUKE1992A

No activity reported.

ISOSANDWICENE Plant: DUKE1992A

No activity reported.

MITORIDINE Root: DUKE1992A

No activity reported.

NEONORRESERPINE Plant: DUKE1992A

No activity reported.

PERAKINE Plant: DUKE1992A

No activity reported.

PICRININE Leaf: DUKE1992A

CNS-Depressant PEP

PURPELINE Root: DUKE1992A

No activity reported.

RAUGALLINE Plant: DUKE1992A

No activity reported.

RAUMITORINE Root: DUKE1992A

No activity reported.

RAUNITIDINE Plant: DUKE1992A

No activity reported.

RAUVANINE Root: DUKE1992A

No activity reported.

RAUVOMILINE Plant: DUKE1992A

No activity reported.

RAUVOMITINE Root: DUKE1992A

No activity reported.

RAUVOXINE Leaf: DUKE1992A

No activity reported.

RAUVOXININE Leaf: DUKE1992A

No activity reported.

RENOXIDINE Plant: DUKE1992A

No activity reported.

RESCIDINE Root: DUKE1992A

No activity reported.

RESCINNAMINE Root: DUKE1992A

Antihypertensive 250-1,000 ug/man/day/ MAR ; Sedative DUKE1992B ; Tranquilizer DUKE1992B

RESERPILINE Root: DUKE1992A

Antihypertensive MAR

RESERPINE Root: DUKE1992A

Abortifacient 0.04 mg/kg ipr? rbt PDR45 DUKE1992B ; Antiadrenergic DUKE1992B ; Anticonvulsant DUKE1992B ; Antidyskinetic 500-5,000 ug/man/day MAR ; Antihypertensive 250-500 ug /man/day MAR ; Antileukemic DUKE1992B ; Antimigraine MAR ; Antipsychotic 100-1,000 ug/man/day MAR ; Antipyretic DUKE1992B ; AntiRaynaud's 1-1.5 mg/iar/man/day MAR ; Antischizophrenic DUKE1992B ; Antistress DUKE1992B ; Antitumor DUKE1992B ; Bradycardic MAR ; Calcium-Antagonist 1 uM rbt, rat, gpg K11002 ; Catecholaminolytic PAM ; CNS-Depressant DUKE1992B ; Hepatoprotective DUKE1992B ; Hypotensive M11 ; Hypothermic 2.5 mg/kg scu mus JPP42:586 ; MDR-Inhibitor 2.5-10 uM; Peristaltic DUKE1992B ; Rodenticide MAR ; Sedative MAR ; Serotoninolytic PAM ; Teratogenic 1-2 mg/kg ims ipr rat PDR45 ; Tranquilizer M11 ; Tumorigenic 5-10 ppm feed orl mus PDR45 ; Ulcerogenic 0.1 mg/kg/day/6 weeks imr rat JPP42:64 ; Uterotonic 411 ; Vasoconstrictor JPP42:125

RESERPOXIDINE Root: DUKE1992A

No activity reported.

SARPAGINE Root: DUKE1992A

No activity reported.

SERADAMINE Root: DUKE1992A

No activity reported.

SEREDINE Root: DUKE1992A

No activity reported.

SEREPENTENINE Root: DUKE1992A

No activity reported.

SERPENTICINE Plant: DUKE1992A

No activity reported.

STIGMASTEROL Root: DUKE1992A

Antihepatotoxic DUKE1992B ; Antiinflammatory LRN1995 ; Antinociceptive PR14:401 ; Antiophidic 2.3 mg ipr mus EMP5:363 ; Antioxidant IC33=10 uM JMF5:1 ; Antiviral PS75:161 ; Artemicide LC50=110 ppm PC29(5):1667 ; Cancer-Preventive 525 ; Estrogenic; Hypocholesterolemic NIG ; Ovulant DUKE1992B ; Sedative PM6:499.1986

TETRAHYDROALSTONINE Leaf: DUKE1992A

Hypoglycemic DUKE1992B

VIMIFOLINE Leaf: DUKE1992A

No activity reported.

VOMALIDENE Root: DUKE1992A

No activity reported.

VOMILENINE Plant: DUKE1992A

No activity reported.

YOHIMBINE Plant: DUKE1992A

Adrenergic-Blocker CPB38:1702 ; Adrenolytic 0.2 mg/kg ivn dog BBE 2 mg/kg ivn rbt BBE 5 mg/kg ivn rat BBE ; Anesthetic M&R604 ; Antiacetylcholinesterase JNP59:890 ; Antianginal DUKE1992B ; Antiatherosclerotic DUKE1992B ; Antidepressant JBH ; Antidiuretic MAR ; Antidopaminergic JAI78:1189 ; Antidote (Barbiturate) 0.25 mg/kg ivn dog BBE ; Antihypertensive JE36:219 ; Antiketaminic 0.25 mg/kg ivn cat BBE ; Antiparaesthesic 6 mg/3xday/man/orl MAR ; Antiserotonin JBH ; Anxiogenic LRN-MAY93 ; Aphrodisiac 411 ; Calcium-Antagonist 3 uM rat; Cardiotonic LAF ; Cardiovascular 1 mg/kg ivn rat BBE ; Cholinergic JAI78:1189 ; CNS-Depressant 5 mg/kg scu rat BBE 8 mg/kg ivn rbt BBE 411 ; CNS-Stimulant LRN-MAY93 ; Emetic LAF ; Hypertensive 5 mg/man orl; Hypothermic JPP42:783 ; MAO-Inhibitor EMP6:171 ; MDR-Inhibitor 10 uM MOL48:682 ; Mydriatic M11 ; Respirodepressant LAF ; Respirostimulant LAF ; Rhinorreic 20-30 mg/man JAI78:1189 ; Sialogogue 0.3 mg/kg ivn rat; Tremorigenic JAI78:1189

The source of the experience

Dr Dukes plant database

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Commonsteps

References

411: Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.

452: Recio, M. C., Rios, J. L., and Villar, A., A review of some antimicrobial compounds isolated from medicinal plants reported in the literature 1978-1988, Phytotherapy Research, 3(4), 1989, 117-125.

525: Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.

BBE: Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006.

CPB38:1702: Jim Duke's personal files

DUKE1992A: Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

DUKE1992B: Duke, James A. 1992. Handbook of biologically active phytochemicals and their activities. Boca Raton, FL. CRC Press.

EMP5:344: Jim Duke's personal files

EMP5:363: Economic & Medicinal Plant Research, 5: 363.

EMP6:171: Jim Duke's personal files

HDN: Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.

HH2: Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin.

JAI78:1189: Jim Duke's personal files

JBH: Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.

JE36:219: Jim Duke's personal files

JMF5:1: Jim Duke's personal files

JNP59:890: Jim Duke's personal files

JPP42:125: Jim Duke's personal files

JPP42:586: Jim Duke's personal files

JPP42:64: Jim Duke's personal files

JPP42:783: Jim Duke's personal files

K11002: Jim Duke's personal files

K26031: Jim Duke's personal files

LAF: Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.

LRN-MAY93: Jim Duke's personal files

LRN1995: Lawrence Review of Natural Products, 1995

M&R107: Jim Duke's personal files

M&R604: Jim Duke's personal files

M11: Merck 11th Edition

M29: Martindale's 29th

MAR: Martindale's 28th

MOL48:682: Bhat, U. G., et al. 1995. A Structure-Function Relationship Among Reserpine and Yohimbine Analogues in Their Ability to Increase Expression of MDR1 and P-Glycoprotein in a Human Colon Carcinoma Cell Line. Mol Pharmacol, 48(4): 682-689.

MPT: Medicinal and Poisonous Plants of the Tropics. Leeuwenberg, A.J.M., ed. Pudoc, Wageningen. 1987.

NIG: Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp.

PAM: Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).

PC29(5):1667: Jung, J.H., Pummangura, S., Chaichantipyuth, c., Patarapanich, C., and McLaughlin, J.L. 1989. Bioactive Constituents of Melodorum fruticosum. Phytochemistry. 29(5): 1667-1670. 1990.

PDR45: Jim Duke's personal files

PEP: Pakistan Encyclopedia Planta Medica. 1986.

PM6:499.1986: Jim Duke's personal files

PR14:401: Jim Duke's personal files

PS75:161: Abid Ali Khan, M.M., Jain, D.C., Bhakuni, R.S., Zaim, M., and Thakur, R.S. 1991. Occurrence of some antiviral sterols in Artemisia annua. Plant Science, 75: 161-165, 1991.

RAS: Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.

WOI: ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes.


ppm = parts per million
tr = trace

 

Thu Nov 5 07:02:22 EST 2015